Browsing by Author "Mackern Oberti, Juan Pablo"
Now showing 1 - 12 of 12
Results Per Page
Sort Options
- ItemAutologous tolerogenic dendritic cells derived from monocytes of systemic lupus erythematosus patients and healthy donors show a stable and immunosuppressive phenotype(2017) Obreque Castro, Javiera Constanza; Vega, Fabian; Torres, Andy; Cuitino, Loreto; Mackern Oberti, Juan Pablo; Viviani García, Paola; Kalergis Parra, Alexis Mikes; Llanos Muñoz, Carolina
- ItemCarbon monoxide exposure improves immune function in lupus-prone mice(2013) Mackern Oberti, Juan Pablo; Llanos Muñoz, Carolina; Carreño Márquez, Leandro Javier; Riquelme, Sebastián A.; Jacobelli, Sergio H.; Anegon, Ignacio; Kalergis Parra, Alexis Mikes
- ItemCarbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus(2015) Mackern Oberti, Juan Pablo; Obreque Castro, Javiera Constanza; Méndez G.; Llanos Muñoz, Carolina; Kalergis Parra, Alexis Mikes
- ItemContribution of dendritic cells to the autoimmune pathology of systemic lupus erythematosus(2015) Mackern Oberti, Juan Pablo; Llanos Muñoz, Carolina; Riedel, Claudia A.; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes
- ItemHeme Oxygenase-1 as a Target for the Design of Gene and Pharmaceutical Therapies for Autoimmune Diseases(2014) Mackern Oberti, Juan Pablo; Riquelme, S.; Llanos Muñoz, Carolina; Schmidt, C.; Simon, T.; Anegon, I.; Jara, E.; Riedel, C.; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes
- ItemModulation of antigen processing by haem-oxygenase 1. Implications on inflammation and tolerance(2016) Riquelme Colet, Sebastián Alejandro; Carreno, L.; Espinoza Véliz, Janyra Alejandra; Mackern Oberti, Juan Pablo; Álvarez Lobos, Manuel; Riedel, C.; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes
- ItemNaturally derived heme-oxygenase 1 inducers and their therapeutic application to immune-mediated diseases(Frontiers Media S.A., 2020) Funes, Samanta Celeste; Rios Raggio, Mariana; Fernández Fierro, Ayleen Lorena; Covián, Camila; Bueno Ramírez, Susan; Riedel Soria, Claudia; Mackern Oberti, Juan Pablo; Kalergis Parra, Alexis MikesHeme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. A major anti-inflammatory role has been assigned to the HO-1 activity. Therefore, in recent years HO-1 induction has been employed as an approach to treating several disorders displaying some immune alterations components, such as exacerbated inflammation or self-reactivity. Many natural compounds have shown to be effective inductors of HO-1 without cytotoxic effects; among them, most are chemicals present in plants used as food, flavoring, and medicine. Here we discuss some naturally derived compounds involved in HO-1 induction, their impact in the immune response modulation, and the beneficial effect in diverse autoimmune disorders. We conclude that the use of some compounds from natural sources able to induce HO-1 is an attractive lifestyle toward promoting human health. This review opens a new outlook on the investigation of naturally derived HO-1 inducers, mainly concerning autoimmunity.
- ItemRole of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases(2015) Mackern Oberti, Juan Pablo; Llanos Muñoz, Carolina; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes; Vega, Fabián; Salazar Onfray, Flavio; Riedel, Claudia A.
- ItemSurface expression of the hRSV nucleoprotein impairs immunological synapse formation with T cells(2014) Céspedes, P.; Bueno Ramírez, Susan; Ramírez, B.; Gomez, Ricardo; Riquelme, S.; Palavecino, C.; Mackern Oberti, Juan Pablo; Mora, J.; Kalergis Parra, Alexis Mikes; Depoil, D.; Sacristan, C.
- ItemTargeting dendritic cell function during systemic autoimmunity to restore tolerance(2014) Mackern Oberti, Juan Pablo; Llanos Muñoz, Carolina; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes
- ItemTolerogenic dendritic cell transfer ameliorates systemic lupus erythematosus in mice(2019) Funes, S. C.; Ríos, Mariana; Gómez Santander, Felipe; Fernández Fierro, A.; Altamirano Lagos, M. J.; Rivera Pérez, D.; Pulgar Sepúlveda, R.; Jara, Evelyn L.; Rebolledo Zelada, D.; Villarroel, A.; Roa Strauch, Juan Carlos Enrique; Mackern Oberti, Juan Pablo; Kalergis Parra, Alexis Mikes
- ItemTolerogenic dendritic cells as a therapy for treating lupus(2013) Llanos Muñoz, Carolina; Mackern Oberti, Juan Pablo; Vega Rebolledo, Fabián Saúl Alonso; Kalergis Parra, Alexis Mikes