Browsing by Author "Littlewood, Simon J."

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    Free‐breathing 3D whole‐heart joint T1/T2 mapping and water/fat imaging at 0.55 T
    (2024) Si, Dongyue; Crabb, Michael G.; Kunze, Karl P.; Littlewood, Simon J.; Prieto Vasquez, Claudia Del Carmen; Botnar, René M.
    To develop and validate a highly efficient motion compensated free-breathingisotropic resolution 3D whole-heart joint T 1 /T2 mapping sequence with anatomicalwater/fat imaging at 0.55 T.Methods: The proposed sequence takes advantage of shorter T1 at 0.55 T to acquirethree interleaved water/fat volumes with inversion-recovery preparation, no prepara-tion, and T 2 preparation, respectively. Image navigators were used to facilitate nonrigidmotion-compensated image reconstruction. T1 and T2 maps were jointly calculated bya dictionary matching method. Validations were performed with simulation, phantom,and in vivo experiments on 10 healthy volunteers and 1 patient. The performance ofthe proposed sequence was compared with conventional 2D mapping sequences includ-ing modified Look-Locker inversion recovery and T2 -prepared balanced steady-SSFPsequence.Results: The proposed sequence has a good T1 and T2 encoding sensitivity in simula-tion, and excellent agreement with spin-echo reference T 1 and T2 values was observedin a standardized T1 /T2 phantom (R2 = 0.99). In vivo experiments provided good-qualityco-registered 3D whole-heart T1 and T2 maps with 2-mm isotropic resolution in ashort scan time of about 7 min. For healthy volunteers, left-ventricle T1 mean andSD measured by the proposed sequence were both comparable with those of modi-fied Look-Locker inversion recovery (640 ± 35 vs. 630 ± 25 ms [p = 0.44] and 49.9 ± 9.3vs. 54.4 ± 20.5 ms [p = 0.42]), whereas left-ventricle T2 mean and SD measured by theproposed sequence were both slightly lower than those of T2 -prepared balanced SSFP(53.8 ± 5.5 vs. 58.6 ± 3.3 ms [p < 0.01] and 5.2 ± 0.9 vs. 6.1 ± 0.8 ms [p = 0.03]). MyocardialT 1 and T2 in the patient measured by the proposed sequence were in good agreementwith conventional 2D sequences and late gadolinium enhancement.Conclusion: The proposed sequence simultaneously acquires 3D whole-heart T1 and T2mapping with anatomical water/fat imaging at 0.55 T in a fast and efficient 7-min scan.Further investigation in patients with cardiovascular disease is now warranted