Browsing by Author "Lisboa, Carmen"

Now showing 1 - 6 of 6
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    C-Reactive protein levels in patients with chronic obstructive pulmonary disease
    (SOC MEDICA SANTIAGO, 2012) Diaz, Orlando; Parada, Alejandra; Ramos, Cristobal; Klaassen, Julieta; Carlos Diaz, Juan; Andresen, Max; Lisboa, Carmen; Saldias, Fernando
    Background: Patients with chronic obstructive pulmonary disease (COPD) have elevated serum levels of ultrasensitive C reactive protein (CRPus). This raise may be related directly to COPD and its associated systemic inflammation or secondary to other factors such as smoking status, disease severity, acute exacerbations, or associated complications. Aim: To evaluate the potential causes of raised levels of CRPus in stable COPD patients. Patients and Methods: Cohorts of 133 mild-to-very severe COPD patients (41 current smokers), 31 never-smokers, and 33 current smoker controls were compared. Clinical assessments included body mass index (BMA fat (FM) and fat-free mass (FFM) measurement by DEXA, forced expiratory volume in one second (FEV1), arterial oxygen tension (PaO2), six-minute walking test (SMWT), emphysema (EMPH) and right thigh muscle cross-sectional area (TMCSA), both quantified by high resolution computed tomography. Results: Serum CRPus levels were significantly higher in COPD patients than in controls (7 +/- 4.2 and 3.7 +/- 2.7 mg/L, respectively; p < 0.0001). Being smoker did not influence CRPus levels. These levels were significantly correlated with FM (r = 0.30), BMI (r = 0.21), FEV1 (r = -0.21), number of acute exacerbations of the disease in the last year (r = 0.28), and PaO2 (r = -0.27). Using multivariate analysis FM, PaO2, and number of acute exacerbations of the disease in the last year had the strongest association with CRPus levels. Conclusions: CRPus is elevated in COPD patients, independent of smoking status. It is weakly associated with fat mass, arterial oxygen tension and frequency of exacerbations. (Rev Med Chile 2012; 140: 569-578).
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    Prognostic assessment in COPD: Health related quality of life and the BODE index
    (W B SAUNDERS CO LTD, 2011) Marin, Jose M.; Cote, Claudia G.; Diaz, Orlando; Lisboa, Carmen; Casanova, Ciro; Lopez, Maria V.; Carrizo, Santiago J.; Pinto Plata, Victor; Dordelly, Luis J.; Nekach, Hafida; Celli, Bartolome R.
    Rationale: COPD is a debilitating disease with increasing mortality worldwide. The BODE index evaluates disease severity and the St George's Respiratory Questionnaire (SGRQ) measures health status.
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    Quality of life in the PLATINO study 6 to 9 years later
    (EUROPEAN RESPIRATORY SOC JOURNALS LTD, 2015) Pradella, Cristiane O.; Gazzotti, Mariana R.; Moreira, Graciane L.; Manzano, Beatriz M.; Montes de Oca, Maria; Lopes, Maria V.; Menezes, Ana Maria B.; Muino, Adriana; Lisboa, Carmen; Valdivia, Gonzalo; Perez Padilla, Rogelio; Nascimento, Oliver A.; Jardim, Jose R.
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    Rat and hamster species differences in susceptibility to elastase-induced pulmonary emphysema relate to differences in elastase inhibitory capacity
    (AMER PHYSIOLOGICAL SOC, 2007) Borzone, Gisella; Liberona, Leonel; Olmos, Pablo; Saez, Claudia; Meneses, Manuel; Reyes, Tatiana; Moreno, Rodrigo; Lisboa, Carmen
    Syrian Golden hamsters develop severe emphysema after a single intratracheal dose of elastase, whereas Sprague- Dawley rats exhibit mild emphysema with the same dose per kilogram body weight. We hypothesized that the development of severe emphysema is prevented in rats by the high serum level of alpha 1- antitrypsin reported in rats, compared with hamsters, which provides for a high lung elastase inhibitory capacity ( EIC). To explore this possibility, we challenged the antiprotease system of the rats by treating them with three similar weekly doses of elastase. Four months after treatment, we evaluated changes in histology, volume, and elastic properties of rat lungs and compared them with those of hamsters receiving a single dose of elastase. We also measured serum alpha 1- antitrypsin levels and serum and lung EIC in control rats and hamsters. Results showed that, in association with 40% less serum and lung EIC compared with rats ( P < 0.001), hamster lungs had upperlobe bullae formation, severe microscopic emphysema, a fourfold increase in lung volume ( P < 0.01) and a threefold increase in constant k, an index of compliance, of the lung deflation pressurevolume curve ( P < 0.01). In contrast, rats developed mild emphysema, with only 50% increase in volume ( P < 0.05) and 60% increase in constant k ( P < 0.01). In conclusion, two species that differ in serum and lung EIC exhibit significant differences in emphysema development after elastase. Rats with high EIC, despite receiving three doses of elastase, showed significantly less derangement of morphological and physiological parameters than hamsters with low EIC receiving a single dose.
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    Spirometric reference values in 5 large Latin American cities for subjects aged 40 years or over
    (ELSEVIER ESPANA SLU, 2006) Perez Padilla, Rogelio; Valdivia, Gonzalo; Muino, Adriana; Lopez, Maria Victorina; Marquez, Maria Nelly; de Oca, Maria Montes; Talamo, Carlos; Lisboa, Carmen; Pertuze, Julio; Jardim, Jose Roberto B.; Menezes, Ana Maria B.; Grp Trabajo PLATINO
    OBJECTIVE: In clinical practice, spirometry is a extremely useful test that requires strict quality control, an appropriate strategy for interpretation, and reliable reference values. The aim of this study was to report spirometric reference values for 5 cities in Latin America.
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    The long-term stability of portable spirometers used in a multinational study of the prevalence of chronic obstructive pulmonary disease
    (DAEDALUS ENTERPRISES INC, 2006) Perez Padilla, Rogelio; Vazquez Garcia, Juan Carlos; Nelly Marquez, Maria; Roberto B Jardim, Jose; Pertuze, Julio; Lisboa, Carmen; Muino, Adriana; Victorina Lopez, Maria; Talamo, Carlos; Montes de Oca, Maria; Valdivia, Gonzalo; Maria B Menezes, Ana; PLATINO Team
    BACKGROUND: We report the performance of an ultrasound-based portable spirometer (EasyOne) used in a population-based survey of the prevalence of chronic obstructive pulmonary disease, conducted in 5 Latin American cities: Sao Paulo, Brazil; Mexico City, Mexico; Montevideo, Uruguay; Santiago, Chile; and Caracas, Venezuela (the Latin American COPD Prevalence Study [PLATINO]). METHODS: During the survey period (which ranged from 3 months to 6 months in the various locations) we collected daily calibration data from the 70 EasyOne spirometers used in the 5 survey cities. The calibrations were conducted with a 3-L syringe, and the calibration data were stored in the spirometer's database. RESULTS: Ninety-seven percent of the calibration volumes were within +/- 64 mL (2.1%) of the 3-L calibration signal. Excluding data from the first city studied (Sao Paulo), where one calibration syringe had to be replaced, 98% of the calibration checks were within +/- 50 mL (1.7%). The measured volume was affected only minimally by the syringe's peak flow or emptying time. CONCLUSION: In these 70 EasyOne spirometers neither calibration nor linearity changed during the study. Such calibration stability is a valuable feature in spirometry surveys and in the clinical setting.