Browsing by Author "Lin, Phillip"

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits
    (Springer Science and Business Media B.V., 2025) Petty, Lauren E.; Chen, Hung-Hsin; Frankel, Elizabeth G.; Zhu, Wanying; Downie, Carolina G.; Graff, Mariaelisa; Lin, Phillip; Sharma, Priya; Zhang, Xinruo; Scartozzi, Alyssa C.; Roshani, Rashedeh; Landman, Joshua M.; Boehnke, Michael; Bowden, Donald W.; Chambers, John C.; Mahajan, Anubha; McCarthy, Mark I.; Ng, Maggie C. Y.; Sim, Xueling; Spracklen, Cassandra N.; Zhang, Weihua; Preuss, Michael; Bottinger, Erwin P.; Nadkarni, Girish N.; Loos, Ruth J. F.; Chen, Yii-Der Ida; Tan, Jingyi; Ipp, Eli; Genter, Pauline; Emery, Leslie S.; Louie, Tin; Sofer, Tamar; Stilp, Adrienne M.; Taylor, Kent D.; Xiang, Anny H.; Buchanan, Thomas A.; Roll, Kathryn; Gao, Chuan; Palmer, Nicholette D.; Norris, Jill M.; Wagenknecht, Lynne E.; Nousome, Darryl; Varma, Rohit; McKean-Cowdin, Roberta; Guo, Xiuqing; Hai, Yang; Hsueh, Willa; Sandow, Kevin; Parra, Esteban J.; Cruz, Miguel; Valladares-Salgado, Adan; Wacher-Rodarte, Niels; Rotter, Jerome I.; Goodarzi, Mark O.; Rich, Stephen S.; Bertoni, Alain; Raffel, Leslie J.; Nadler, Jerry L.; Kandeel, Fouad R.; Duggirala, Ravindranath; Blangero, John; Lehman, Donna M.; DeFronzo, Ralph A.; Thameem, Farook; Wang, Yujie; Gahagan, Sheila; Blanco, Estela; Burrows, Raquel; Huerta-Chagoya, Alicia; Florez, Jose C.; Tusie-Luna, Teresa; Gonzalez-Villalpando, Clicerio; Orozco, Lorena; Haiman, Christopher A.; Hanis, Craig L.; Rohde, Rebecca; Whitsel, Eric A.; Reiner, Alexander P.; Kooperberg, Charles; Li, Yun; Duan, Qing; Lee, Miryoung; Correa-Burrows, Paulina; Fried, Susan K.; North, Kari E.; McCormick, Joseph B.; Fisher-Hoch, Susan P.; Gamazon, Eric R.; Morris, Andrew P.; Mercader, Josep M.; Highland, Heather M.; Below, Jennifer E.
    Here, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits conducted to date in Hispanic/Latino populations (nmax = 63,184). We conduct a meta-analysis of 16 type 2 diabetes and 19 lipid trait GWAS, identifying 20 genome-wide significant loci for type 2 diabetes, including one novel locus and novel signals at two known loci, based on fine-mapping. We also identify sixty-one genome-wide significant loci across the lipid/lipoprotein traits, including nine novel loci, and novel signals at 19 known loci through fine-mapping. Next, we analyze genetically regulated expression, perform Mendelian randomization, and analyze association with transcriptomic and proteomic measure using multi-omics data from a Hispanic/Latino population. Using this approach, we identify genes linked to type 2 diabetes and lipid/lipoprotein traits, including TMEM205 and NEDD9 for HDL cholesterol, TREH for triglycerides, and ANXA4 for type 2 diabetes.