Browsing by Author "Leon, U."

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    Hepatitis C virus quasispecies in plasma and peripheral blood mononuclear cells of treatment naive chronically infected patients
    (WILEY, 2009) Vera Otarola, J.; Barria, M. I.; Leon, U.; Marsac, D.; Carvallo, P.; Soza, A.; Lopez Lastra, M.
    Peripheral blood mononuclear cells (PBMCs) from 45 treatment naive, HIV-negative, chronically hepatitis C virus (HCV)-infected patients were analyzed for the presence of HCV RNA. Viral RNA was detected in 73% of the studied patients. Single-strand conformation polymorphism assays and sequence analysis of the HCV 5'untranslated regions amplified from RNA recovered from both Plasma and PBMCs suggested virus compartmentalization in 57.6% of patients studied. In summary, our study presents evidence that HCV RNA can be found in PBMCs of treatment naive chronically infected patients that are not immunocompromised or co-infected with the human immunodeficiency virus.