Browsing by Author "Labarca, Gonzalo"
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- ItemAplicaciones torácicas del ultrasonido(2016) Fernández Bussy, S.; Labarca, Gonzalo; Lanza, M.; Folch, E.; Majid, A.
- ItemChronic eosinophilic pneumonia. Report of one case(SOC MEDICA SANTIAGO, 2016) Fernandez Bussy, Sebastian; Campos, Felipe; Ogueta, Isabel; Labarca, Gonzalo; Cabello, HernanChronic eosinophilic pneumonia (CEP) is uncommon and predominantly seen in women. More than 6% of eosinophils in peripheral blood and more than 25% in bronchoalveolar lavage are diagnostic criteria. Secondary causes of hypereosinophilic pneumonia must be ruled out. We report a 72-year-old non-smoker man presenting in the emergency room with a history of cough, fever, and moderate dyspnea. He was not taking any medication. A chest-X ray showed a left lower lobe (LLL) consolidation, and was started on broad-spectrum antibiotics with a presumptive diagnosis of pneumonia. There was no improvement after therapy. A chest CT scan showed increased LLL consolidation and new left upper lobe ground glass opacities as well as a moderate left pleural effusion. Flexible bronchoscopy was performed and bronchoalveolar lavage showed 95% eosinophils, and had negative cultures. No parasites were identified. Transbronchial biopsies demonstrated eosinophil accumulation in alveoli and interstitium and pleural fluid was composed by 85% eosinophils. With the diagnosis of CEP, systemic corticosteroids were used with favorable clinical and radiological response.
- ItemClinical and pulmonary function analysis in long-COVID revealed that long-term pulmonary dysfunction is associated with vascular inflammation pathways and metabolic syndrome(FRONTIERS MEDIA SA, 2023) Sanhueza, Sergio; Vidal, Mabel A.; Hernandez, Mauricio A.; Henriquez-Beltran, Mario E.; Cabrera, Camilo; Quiroga, Romina; Antilef, Barbara E.; Aguilar, Kevin P.; Castillo, Daniela A.; Llerena, Faryd J.; Figueroa, Marco Fraga; Nazal, Mauricio; Castro, Eritson; Lagos, Paola; Moreno, Alexa; Lastra, Jaime J.; Gajardo, Jorge; Garces, Pamela; Riffo, Benilde; Buchert, Jorge; Sanhueza, Rocio; Ormazaba, Valeska; Saldivia, Pablo; Vargas, Cristian; Nourdin, Guillermo; Koch, Elard; Zuniga, Felipe A.; Lamperti, Liliana; Bustos, Paula; Guzman-Gutierrez, Enrique; Tapia, Claudio A.; Ferrada, Luciano; Cerda, Gustavo; Woehlbier, Ute; Riquelme, Marcelo; Yuseff, Maria Isabel; Ramirez, Braulio A. Munoz; Lombardi, Giovanna; De Gonzalo-Calvo, David; Salomon, Carlos; Verdugo, Ricardo A.; Quinones, Luis A.; Colombo, Alicia; Barria, Maria I.; Labarca, Gonzalo; Nova-Lamperti, EstefaniaIntroduction: Long-term pulmonary dysfunction (L-TPD) is one of the most critical manifestations of long-COVID. This lung affection has been associated with disease severity during the acute phase and the presence of previous comorbidities, however, the clinical manifestations, the concomitant consequences and the molecular pathways supporting this clinical condition remain unknown. The aim of this study was to identify and characterize L-TPD in patients with long-COVID and elucidate the main pathways and long-term consequences attributed to this condition by analyzing clinical parameters and functional tests supported by machine learning and serum proteome profiling. Methods: Patients with L-TPD were classified according to the results of their computer-tomography (CT) scan and diffusing capacity of the lungs for carbon monoxide adjusted for hemoglobin (DLCOc) tests at 4 and 12-months post-infection. Results: Regarding the acute phase, our data showed that L-TPD was favored in elderly patients with hypertension or insulin resistance, supported by pathways associated with vascular inflammation and chemotaxis of phagocytes, according to computer proteomics. Then, at 4-months post-infection, clinical and functional tests revealed that L-TPD patients exhibited a restrictive lung condition, impaired aerobic capacity and reduced muscular strength. At this time point, high circulating levels of platelets and CXCL9, and an inhibited FCgamma-receptor-mediated-phagocytosis due to reduced Fc gamma RIII (CD16) expression in CD14+ monocytes was observed in patients with L-TPD. Finally, 1-year post infection, patients with L-TPD worsened metabolic syndrome and augmented body mass index in comparison with other patient groups. Discussion: Overall, our data demonstrated that CT scan and DLCOc identified patients with L-TPD after COVID-19. This condition was associated with vascular inflammation and impair phagocytosis of virus-antibody immune complexes by reduced Fc gamma RIII expression. In addition, we conclude that COVID-19 survivors required a personalized follow-up and adequate intervention to reduce long-term sequelae and the appearance of further metabolic diseases.
- ItemConcomitant tracheal and subcutaneous glomus tumor : case report and review of the literature(2015) Fernandez-Bussy, Sebastian; Labarca, Gonzalo; Rodriguez, Macarena; Mehta, Hiren J.; Jantz, Michael
- ItemCPAP in patients with obstructive sleep apnea and type 2 diabetes mellitus: Systematic review and meta-analysis(2018) Labarca, Gonzalo; Reyes, Tomas; Jorquera, Jorge; Dreyse, Jorge; Drake, Lauren
- ItemDementia, gait disturbance, and urinary incontinence in a patient with pulmonary sarcoidosis(2016) Labarca, Gonzalo; Ramírez Corsi, Romina Victoria; Monsalve, Ximena; Mira-Avendaño, Isabel
- ItemDiagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal staging in lung cancer(2015) Fernandez Bussy, Sebastián; Labarca, Gonzalo; Canals, Sofia; Caviedes, Iván; Folch, Erik; Majid, Adnan
- ItemDifferences between manual and automatic analysis in determining the severity of obstructive sleep apnea using home sleep apnea testing(2018) Labarca, Gonzalo; Dreyse, Jorge; Salas, Constanza; Contreras, Andrea; Nazar, Gonzalo; Gaete, Maria I.; Jorquera, Jorge
- ItemEndobronchial Involvement in Idiopathic Hypereosinophilic Syndrome(2015) Fernandez Bussy, Sebastian; Antunez, Miguel; Pires, Yumay; Labarca, Gonzalo
- ItemEndobronchial ultrasound and fine needle aspiration for central airway lesions(2016) Fernandez, S.; Labarca, Gonzalo; Caviedes, I.; Folch, E.; Majid, A
- Item¿Es efectiva la N-acetilcisteína en el tratamiento de la fibrosis pulmonar?(2016) Pulgar, A. J.; Labarca, Gonzalo
- Item¿Es efectiva la pirfenidona en el tratamiento de la fibrosis pulmonar idiopática?(2017) Jeldres, Alejandro; Labarca, Gonzalo
- Item¿Es efectivo el nintedanib para la fibrosis pulmonar idiopática?(2017) Jeldres, Alejandro; Labarca, Gonzalo
- ItemMinimally Invasive Methods for Staging in Lung Cancer : Systematic Review and Meta-Analysis(2016) Labarca, Gonzalo; Aravena León, Carlos Andrés; Ortega, Francisco; Arenas, Alex; Majid, Adnan; Folch, Erik; Mehta, Hiren J.; Jantz, Michael A.; Fernandez Bussy, Sebastian
- ItemPirfenidone for Idiopathic Pulmonary Fibrosis : A Systematic Review and Meta-Analysis(2015) Aravena León, Carlos Andrés; Labarca, Gonzalo; Venegas Garrido, Carmen Paz; Arenas, Alex; Rada G., Gabriel
- ItemRendimiento diagnóstico de la broncoscopia con biopsia transbronquial en el estudio de lesiones sugerentes de cáncer pulmonar(2015) Fernández Bussy, Sebastián; Labarca, Gonzalo; Canals, Sofía; Zagollin, Mónica
- ItemThe boundaries of mild chronic obstructive pulmonary disease (COPD): design of the searching clinical COPD onset (SOON) study(2017) Labarca, Gonzalo; Bustamante, Andrea; Valdivia Cabrera, Gonzalo; Díaz Montero, Rodrigo Aquiles; Huete, Isidro; Mac Nab, Paul; Mendoza, Laura; Leppe, Jaime; Lisboa Basualto, Carmen; Saldías Peñafiel, Fernando; Díaz, Orlando
- ItemTreatment failure in community-adquired pneumonia: coccidioidomycosis in a traveler patient(SOC CHILENA INFECTOLOGIA, 2013) Cabello, Hernan; Labarca, Gonzalo; Fernandez Bussy, Sebastian; Cabello, Francisca; Pires, Yumay; Soto, Rodrigo; Thompson, LuisTreatment failure in community-acquired pneumonia is defined as a clinical condition with inadequate response to antimicrobial therapy. Resistant and unusual microorganisms and noninfectious causes are responsible for treatment failure. Coccidioides immitis is a fungus that causes pneumonia in the northern hemisphere, especially in the United States and northern Mexico. We report a case of pulmonary coccidioidomycosis imported from Mexico to Chile. After a comprehensive study, histopathology was able to establish Coccidiodes immitis as the causative agent, achieving clinical and radiological improvement with antifungal therapy.