Browsing by Author "Kirton, Adam"

Now showing 1 - 4 of 4
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    Arterial Tortuosity : An Imaging Biomarker of Childhood Stroke Pathogenesis?
    (2016) Wei, Félix; Diedrich, Karl, T.; Fullerton, Heather J.; DeVeber, Gabrielle; Wintermark, Max; Hodge, Jacquie; Kirton, Adam; Hernández, Marta
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    Dyslipidemia in Children With Arterial Ischemic Stroke : Prevalence and Risk Factors
    (2018) Sultan, Sally; Dowling, Michael; Kirton, Adam; DeVeber, Gabrielle; Linds, Alexandra; Elkind, Mitchell S.V.; Hernández, Marta
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    Stroke Patterns in Neonatal Group B Streptococcal Meningitis
    (ELSEVIER SCIENCE INC, 2011) Hernandez, Marta I.; Sandoval, Carmen C.; Tapia, Jose L.; Mesa, Tomas; Escobar, Raul; Huete, Isidro; Wei, Xing Chang; Kirton, Adam
    Neonatal group B streptococcus meningitis causes neurologic morbidity and mortality. Cerebrovascular involvement is a common, poorly studied, and potentially modifiable pathologic process. We hypothesized that imaging patterns of focal brain infarction are recognizable in neonatal group B streptococcal meningitis. A consecutive case series included term neonates with the following: (1) bacterial meningitis, (2) acute group B streptococcal infection (positive cerebrospinal fluid/blood culture), (3) brain magnetic resonance imaging within 14 days, and (4) acute intraparenchymal focal infarctions (restricted diffusion). Lesions within known arterial territories were classified as arterial ischemic stroke. Clinical presentations, investigations, and neurologic outcomes were recorded. Eight newborns (50% female) with focal infarction were identified. Five presented early (<1 week), and all manifested clinical shock and elevated acute-phase reactants. Less than 50% had prenatal group B streptococcal screening, while 2 of 3 screened were negative. Two distinct patterns of focal infarction were identified: (1) deep perforator arterial stroke to basal ganglia, thalamus, and peri ventricular white matter (7/8, 88%), and (2) superficial injury with patchy, focal infarctions of the cortical surface (6/8, 75%). Outcomes (mean 23.8 months) were poor, with severe disability or death in 6/8 (75%). Recognizable stroke patterns contribute to severe neurologic outcomes and represent a potentially modifiable pathophysiologic process in neonatal group B streptococcal meningitis. (C) 2011 Elsevier Inc. All rights reserved.
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    Symptomatic Neonatal Arterial Ischemic Stroke: The International Pediatric Stroke Study
    (AMER ACAD PEDIATRICS, 2011) Kirton, Adam; Armstrong Wells, Jennifer; Chang, Taeun; de Veber, Gabrielle; Rivkin, Michael J.; Hernandez, Marta; Carpenter, Jessica; Yager, Jerome Y.; Lynch, John K.; Ferriero, Donna M.; Int Pediat Stroke Study
    BACKGROUND: Neonatal arterial ischemic stroke (AIS) has emerged as a leading cause of perinatal brain injury, cerebral palsy, and lifelong disability. The pathogenesis is poorly understood, which limits the development of treatment and prevention strategies. Multicenter studies must define epidemiology, risk factors, treatment practices, and outcomes to advance clinical trials and improve the adverse outcomes suffered by most survivors.