Browsing by Author "Khamis, Ramzi"

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    Clinical quantitative coronary artery stenosis and coronary atherosclerosis imaging: a Consensus Statement from the Quantitative Cardiovascular Imaging Study Group
    (2023) Mezquita, Aldo J. Vazquez; Biavati, Federico; Falk, Volkmar; Alkadhi, Hatem; Hajhosseiny, Reza; Maurovich-Horvat, Pal; Manka, Robert; Kozerke, Sebastian; Stuber, Matthias; Derlin, Thorsten; Channon, Keith M.; Isgum, Ivana; Coenen, Adriaan; Foellmer, Bernhard; Dey, Damini; Volleberg, Rick H. J. A.; Meinel, Felix G.; Dweck, Marc R.; Piek, Jan J.; van de Hoef, Tim; Landmesser, Ulf; Guagliumi, Giulio; Giannopoulos, Andreas A.; Botnar, Rene M.; Khamis, Ramzi; Williams, Michelle C.; Newby, David E.; Dewey, Marc
    In this Consensus Statement, Dewey and the other members of the Quantitative Cardiovascular Imaging Study Group provide clinical consensus recommendations on the optimal use of different imaging techniques in various patient populations to detect and assess coronary artery stenosis and atherosclerosis.
  • Thumbnail Image
    Item
    Coronary Magnetic Resonance Angiography in Chronic Coronary Syndromes
    (FRONTIERS MEDIA SA, 2021) Hajhosseiny, Reza; Munoz, Camila; Cruz, Gastao; Khamis, Ramzi; Kim, Won Yong; Prieto, Claudia; Botnar, Rene M.
    Cardiovascular disease is the leading cause of mortality worldwide, with atherosclerotic coronary artery disease (CAD) accounting for the majority of cases. X-ray coronary angiography and computed tomography coronary angiography (CCTA) are the imaging modalities of choice for the assessment of CAD. However, the use of ionising radiation and iodinated contrast agents remain drawbacks. There is therefore a clinical need for an alternative modality for the early identification and longitudinal monitoring of CAD without these associated drawbacks. Coronary magnetic resonance angiography (CMRA) could be a potential alternative for the detection and monitoring of coronary arterial stenosis, without exposing patients to ionising radiation or iodinated contrast agents. Further advantages include its versatility, excellent soft tissue characterisation and suitability for repeat imaging. Despite the early promise of CMRA, widespread clinical utilisation remains limited due to long and unpredictable scan times, onerous scan planning, lower spatial resolution, as well as motion related image quality degradation. The past decade has brought about a resurgence in CMRA technology, with significant leaps in image acceleration, respiratory and cardiac motion estimation and advanced motion corrected or motion-resolved image reconstruction. With the advent of artificial intelligence, great advances are also seen in deep learning-based motion estimation, undersampled and super-resolution reconstruction promising further improvements of CMRA. This has enabled high spatial resolution (1 mm isotropic), 3D whole heart CMRA in a clinically feasible and reliable acquisition time of under 10 min. Furthermore, latest super-resolution image reconstruction approaches which are currently under evaluation promise acquisitions as short as 1 min. In this review, we will explore the recent technological advances that are designed to bring CMRA closer to clinical reality.
  • No Thumbnail Available
    Item
    Free-breathing, non-contrast, 3D whole-heart coronary MRI for the identification of culprit and vulnerable atherosclerotic plaque
    (2025) Hajhosseiny, Reza; Hartley, Adam; Cole, Graham; Munoz, Camilla; Sethi, Amarjit; Al-Lamee, Rasha; Khawaja, Saud; Zaman, Sameer; Howard, James; Gopalan, Deepa; Ariff, Ben; Kaprielian, Raffi; Neji, Radhouene; Kunze, Karl P.; Kaura, Amit; Prieto Vásquez, Claudia; Khamis, Ramzi; Botnar, René Michael
    BACKGROUND: Detection of vulnerable coronary plaque can predict future myocardial infarctions. We have developed a novel, non-contrast cardiovascular magnetic resonance sequence (iT2prep-BOOST), enabling simultaneous, co-registered coronary angiography and plaque detection.OBJECTIVES: To validate iT2prep-BOOST in patients with non-ST-segment elevation myocardial infarction (NSTEMI).METHODS: 41 patients with suspected NSTEMI were recruited. Invasive coronary angiography ± intravascular imaging was used to classify coronary segments into the following categories: normal, non-culprit and culprit segments; stenosed segments as well as segments with vulnerable plaque features (lipid, calcium, fibroatheroma, thin cap fibroatheroma (TCFA), plaque-rupture and thrombus). The plaque/myocardial signal intensity ratio (PMR) in each coronary segment was analyzed on iT2prep-BOOST.RESULTS: The mean ± standard deviation PMR of culprit segments was significantly higher than non-culprit segments and normal segments (1.01 ± 0.14 vs. 0.67 ± 0.18 vs. 0.35 ± 0.24, P<0.001 respectively). Coronary segments with lipid, calcium and fibroatheroma had a significantly higher PMR compared to normal coronary segments (P<0.001), but significantly lower than segments with plaque-rupture and intraluminal thrombus (P<0.05). There was a progressive increase in PMR with increasing coronary segment stenosis (P<0.001). There was a significant association on multivariable analysis between HbA1c as well as family history of coronary artery disease and mean PMR (P=0.05 and P=0.04 respectively).CONCLUSIONS: iT2prep-BOOST has the potential to simultaneously visualize coronary artery lumen and plaque and differentiate normal segments from non-culprit and culprit plaque segments non-invasively and without contrast. The prognostic value of PMR needs to be investigated in a prospective multicenter study.