Browsing by Author "Jofre, Matias R."

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    The carbon source influences the efflux pump-mediated antimicrobial resistance in clinically important Gram-negative bacteria
    (OXFORD UNIV PRESS, 2012) Villagra, Nicolas A.; Fuentes, Juan A.; Jofre, Matias R.; Hidalgo, Alejandro A.; Garcia, Patricia; Mora, Guido C.
    Multidrug efflux pumps are proteins known to play an important role in resistance in bacteria. These proteins are located in the inner membrane (IM), together with many other proteins, including inducible permeases that participate in the uptake of non-phosphotransferase system (PTS) carbohydrates (i.e. carbohydrates uptaken by mechanisms other than the PTS). However, lipid bilayer space in the IM is limited. Therefore, we examined whether the overexpression of unrelated IM proteins is able to interfere with the efflux-mediated resistance mechanism, consequently increasing the susceptibility towards different antimicrobial compounds.