Browsing by Author "Iturriaga Agüera, Rodrigo"

Now showing 1 - 20 of 95
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    Acute Effects of Systemic Erythropoietin Injections on Carotid Body Chemosensory Activity Following Hypoxic and Hypercapnic Stimulation
    (2018) Andrade Andrade, David Cristóbal; Iturriaga Agüera, Rodrigo; Jeton, Florine; Alcayaga Urbina, Julio Andrés; Voituron, Nicolas; Del Rio, Rodrigo
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    Adenosine Triphosphate-Induced Peripheral Nerve Discharges Generated From the Cat Petrosal Ganglion in Vitro
    (2000) Alcayaga Urbina, Julio Andrés; Iturriaga Agüera, Rodrigo; Zapata, Patricio
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    Antioxidant and anti hyperglycemic role of wine grape powder in rats fed with a high fructose diet
    (2015) Hernández-Salinas, Romina.; Decap, Valerie.; Leguina-Ruzzi, Alberto; Cáceres, Patricio.; Pérez, Druso.; Urquiaga Reus, Inés; Iturriaga Agüera, Rodrigo; Velarde Aliaga, María Victoria
    Abstract Background Metabolic syndrome is a growing worldwide health problem. We evaluated the effects of wine grape powder (WGP), rich in antioxidants and fiber, in a rat model of metabolic syndrome induced by a high fructose diet. We tested whether WGP supplementation may prevent glucose intolerance and decrease oxidative stress in rats fed with a high fructose diet. Methods Male Sprague–Dawley rats weighing 180 g were divided into four groups according to their feeding protocols. Rats were fed with control diet (C), control plus 20 % WGP (C + WGP), 50 % high fructose (HF) or 50 % fructose plus 20 % WGP (HF + WGP) for 16 weeks. Blood glucose, insulin and triglycerides, weight, and arterial blood pressure were measured. Homeostasis model assessment (HOMA) index was calculated using insulin and glucose values. A glucose tolerance test was performed 2 days before the end of the experiment. As an index of oxidative stress, thiobarbituric acid reactive substances (TBARS) level was measured in plasma and kidney, and superoxide dismutase was measured in the kidney. Results Thiobarbituric acid reactive substances in plasma and renal tissue were significantly higher when compared to the control group. In addition, the area under the curve of the glucose tolerance test was higher in HF fed animals. Furthermore, fasting blood glucose, plasma insulin levels, and the HOMA index, were also increased. WGP supplementation prevented these alterations in rats fed with the HF diet. We did not find any significant difference in body weight or systolic blood pressure in any of the groups. Conclusions Our results show that WGP supplementation prevented hyperglycemia, insulin resistance and reduced oxidative stress in rats fed with HF diet. We propose that WGP may be used as a supplement in human food as well.Abstract Background Metabolic syndrome is a growing worldwide health problem. We evaluated the effects of wine grape powder (WGP), rich in antioxidants and fiber, in a rat model of metabolic syndrome induced by a high fructose diet. We tested whether WGP supplementation may prevent glucose intolerance and decrease oxidative stress in rats fed with a high fructose diet. Methods Male Sprague–Dawley rats weighing 180 g were divided into four groups according to their feeding protocols. Rats were fed with control diet (C), control plus 20 % WGP (C + WGP), 50 % high fructose (HF) or 50 % fructose plus 20 % WGP (HF + WGP) for 16 weeks. Blood glucose, insulin and triglycerides, weight, and arterial blood pressure were measured. Homeostasis model assessment (HOMA) index was calculated using insulin and glucose values. A glucose tolerance test was performed 2 days before the end of the experiment. As an index of oxidative stress, thiobarbituric acid reactive substances (TBARS) level was measured in plasma and kidney, and superoxide dismutase was measured in the kidney. Results Thiobarbituric acid reactive substances in plasma and renal tissue were significantly higher when compared to the control group. In addition, the area under the curve of the glucose tolerance test was higher in HF fed animals. Furthermore, fasting blood glucose, plasma insulin levels, and the HOMA index, were also increased. WGP supplementation prevented these alterations in rats fed with the HF diet. We did not find any significant difference in body weight or systolic blood pressure in any of the groups. Conclusions Our results show that WGP supplementation prevented hyperglycemia, insulin resistance and reduced oxidative stress in rats fed with HF diet. We propose that WGP may be used as a supplement in human food as well.Abstract Background Metabolic syndrome is a growing worldwide health problem. We evaluated the effects of wine grape powder (WGP), rich in antioxidants and fiber, in a rat model of metabolic syndrome induced by a high fructose diet. We tested whether WGP supplementation may prevent glucose intolerance and decrease oxidative stress in rats fed with a high fructose diet. Methods Male Sprague–Dawley rats weighing 180 g were divided into four groups according to their feeding protocols. Rats were fed with control diet (C), control plus 20 % WGP (C + WGP), 50 % high fructose (HF) or 50 % fructose plus 20 % WGP (HF + WGP) for 16 weeks. Blood glucose, insulin and triglycerides, weight, and arterial blood pressure were measured. Homeostasis model assessment (HOMA) index was calculated using insulin and glucose values. A glucose tolerance test was performed 2 days before the end of the experiment. As an index of oxidative stress, thiobarbituric acid reactive substances (TBARS) level was measured in plasma and kidney, and superoxide dismutase was measured in the kidney. Results Thiobarbituric acid reactive substances in plasma and renal tissue were significantly higher when compared to the control group. In addition, the area under the curve of the glucose tolerance test was higher in HF fed animals. Furthermore, fasting blood glucose, plasma insulin levels, and the HOMA index, were also increased. WGP supplementation prevented these alterations in rats fed with the HF diet. We did not find any significant difference in body weight or systolic blood pressure in any of the groups. Conclusions Our results show that WGP supplementation prevented hyperglycemia, insulin resistance and reduced oxidative stress in rats fed with HF diet. We propose that WGP may be used as a supplement in human food as well.
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    Arginase-endothelial nitric oxide synthase imbalance contributes to endothelial dysfunction during chronic intermittent hypoxia
    (2015) Krause Leyton, Bernardo; Del Rio, Rodrigo; Moya, Esteban A.; Marquez Gutiérrez, Mónica; Casanello Toledo, Paola Cecilia; Iturriaga Agüera, Rodrigo
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    ATP- and ACh-induced responses in isolated cat petrosal ganglion neurons.
    (2007) Alcayaga, C.; Varas Orozco, Rodrigo; Valdés de Petris, Viviana Daniela.; Cerpa Jeria, Veronica Elizabeth; Iturriaga Agüera, Rodrigo
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    Axonal Microtubules: Comparative Anatomy in Vertebrates, Including Man
    (1991) Álvarez Marín, Jaime; Iturriaga Agüera, Rodrigo
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    Cardiovascular responses to isometric handgrip exercise in young patients with recurrent vasovagal syncope
    (2018) Idiaquez, Juan; Francisco Idiaquez, Juan; Iturriaga Agüera, Rodrigo
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    Cardioventilatory Acclimatization Induced by Chronic Intermittent Hypoxia
    (2009) Iturriaga Agüera, Rodrigo; Rey Keim, Sergio; Río Troncoso, Rodrigo Andre del; Moya Céspedes, Esteban Alexis.
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    Carotid Body Ablation Abrogates Hypertension and Autonomic Alterations Induced by Intermittent Hypoxia in Rats
    (2016) Río Quero, Rodrigo del; Andrade, D.; Lucero, C.; Arias, P.; Iturriaga Agüera, Rodrigo
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    Carotid body and cardiorespiratory alterations in intermittent hypoxia: the oxidative link
    (2010) Río Troncoso, Rodrigo Andre del; Moya Céspedes, Esteban Alexis.; Iturriaga Agüera, Rodrigo
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    Carotid body chemoreceptors, sympathetic neural activation, and cardiometabolic disease
    (2016) Iturriaga Agüera, Rodrigo; Río Troncoso, Rodrigo Andre del; Idiaquez, Juan.; Somers, Virend K.
    Abstract The carotid body (CB) is the main peripheral chemoreceptor that senses the arterial PO2, PCO2 and pH. In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory discharge elicits reflex respiratory, autonomic and cardiovascular adjustments. The classical construct considers the CB as the main peripheral oxygen sensor, triggering reflex physiological responses to acute hypoxemia and facilitating the ventilatory acclimation to chronic hypoxemia at high altitude. However, a growing body of experimental evidence supports the novel concept that an abnormally enhanced CB chemosensory input to the brainstem contributes to overactivation of the sympathetic nervous system, and consequent pathology. Indeed, the CB has been implicated in several diseases associated with increases in central sympathetic outflow. These include hypertension, heart failure, sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome. Indeed, ablation of the CB has been proposed for the treatment of severe and resistant hypertension in humans. In this review, we will analyze and discuss new evidence supporting an important role for the CB chemoreceptor in the progression of autonomic and cardiorespiratory alterations induced by heart failure, obstructive sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome.Abstract The carotid body (CB) is the main peripheral chemoreceptor that senses the arterial PO2, PCO2 and pH. In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory discharge elicits reflex respiratory, autonomic and cardiovascular adjustments. The classical construct considers the CB as the main peripheral oxygen sensor, triggering reflex physiological responses to acute hypoxemia and facilitating the ventilatory acclimation to chronic hypoxemia at high altitude. However, a growing body of experimental evidence supports the novel concept that an abnormally enhanced CB chemosensory input to the brainstem contributes to overactivation of the sympathetic nervous system, and consequent pathology. Indeed, the CB has been implicated in several diseases associated with increases in central sympathetic outflow. These include hypertension, heart failure, sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome. Indeed, ablation of the CB has been proposed for the treatment of severe and resistant hypertension in humans. In this review, we will analyze and discuss new evidence supporting an important role for the CB chemoreceptor in the progression of autonomic and cardiorespiratory alterations induced by heart failure, obstructive sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome.
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    Carotid body potentiation during chronic intermittent hypoxia: implication for hypertension
    (2014) Río Troncoso, Rodrigo Andre del; Moya Céspedes, Esteban Alexis.; Iturriaga Agüera, Rodrigo