Browsing by Author "Irribarra Pastenes, Verónica"
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- ItemBile acids synthesis decreases after laparoscopic sleeve gastrectomy(2016) Escalona, Alex; Muñoz, R.; Irribarra Pastenes, Verónica; Solari Gajardo, Sandra; Allende, Fidel; Miquel P., Juan Francisco
- ItemFisiopatología de la retinopatía y nefropatía diabéticas(2009) Olmos Coelho, Pablo Roberto; Araya del Pino, Andrea Paz; González Carvallo, Cristian; Laso Ulloa, Pablo; Irribarra Pastenes, Verónica; Rubio Quiroz, Lorena AlejandraDespite the availability of multiple therapeutic approaches, diabetes mellitus with chronic hyperglycemia remains as the main cause of new cases of blindness and chronic renal failure in the western hemisphere. We herein review the molecular mechanisms by which chronic hyperglycemia causes retinopathy and nephropathy in type I and type 2 diabetic patients. Diabetic retinopathy develops silently along years or decades, producing symptoms only in its very late stages. Its slow development starts with the activation of aldose reductase, shortly followed by the destruction of the retinal pericyte cells, and ends in sudden blindness when vitreous hemorrhage ensues. Nephropathy, on the other hand, centers its pathophysiology in the mesangial cell, that starts as a modified smooth-muscle cell, and turns itself into a myo-fibroblast, produces such amounts of cytoplasm and extracellular protein that strangulates the glomerular capillaries and causes renal failure. After a detailed review of the molecular mechanisms of the aforementioned complications, we conclude that, apart from directing our attention to the emerging medications that are being developed to block these molecular pathways, we should never abandon the struggle for improving the glycemic control of our diabetic patients
- ItemIsolated soy protein improves endothelial function in postmenopausal hypercholesterolemic women(2003) Cuevas Marín, Ada Marisa; Irribarra Pastenes, Verónica; Castillo Cádiz, Octavio Augusto; Yañez, M. D.; Germain Aravena, Alfredo M.
- ItemVirtually Accompanied Eating in the Outpatient Therapy of Anorexia Nervosa(2023) Vogel, Melina; Gil, Aurora; Galaz, Camila; Urrejola Noguera, Pascuala; Lacalle, Lucas; Jara, Raúl; Irribarra Pastenes, Verónica; Letelier, Matias; Costa, Daniela; Espinoza, GabrielaBackground: Normalizing the eating pattern and weight recovery are the main objectives in treating anorexia nervosa (AN). Eating accompaniment through shared mealtimes is a common strategy in eating disorder management programs. This study aims to examine the impact on weight gain of an internet-delivered meal support group on patients with AN who were under ambulatory treatment with the Eating Disorders Unit of the UC Christus Health Network, Chile. Methods: An observational study of 54 female patients with AN diagnosis who participated in Online Meal Support Groups (OMSGs) three times a week was performed. Their weight, BMI and BMI%, was reviewed at the beginning of the sessions and at 45- and 90-day follow-up. Results: Patients showed significant weight gain during follow-up. At the 90-day follow-up, patients had gained 4.41 (SD ± 2.82) kg with an effect size of −1.563. Conclusions: Statistically significant differences were found between the weight at the beginning of the intervention and at the 45- and 90-day follow-up, meaning that eating support online groups may be an effective intervention for weight gain and maintenance in patients with AN. These findings highlight the viability of developing cost-effective and more accessible interventions for AN and thus help reduce the duration of untreated disease and its consequences.