Browsing by Author "Ibáñez Cáceres, Carolina"
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- ItemChilean Gastric Cancer Task Force : a study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients(2018) Owen, Gareth Ivor; Pinto, Mauricio P.; Retamal, Ignacio N.; Fernández, María F.; Cisternas, Betzabe; Mondaca Contreras, Sebastián Patricio; Sánchez Rojel, César Giovanni; Galindo A., Héctor; Nervi, Bruno; Ibáñez Cáceres, Carolina; Acevedo Claros, Francisco Nicolás; Madrid Arenas, Jorge; Peña, José; Bravo Castillo, María Loreto; Maturana, María, José; Córdova Delgado, Miguel; Romero, Diego; De la Jara, Nathaly; Torres Montes, Paula Javiera; Rodríguez Fernández, María; Espinoza Sepúlveda, Manuel Antonio; Balmaceda, Carlos; Freire, Matías; Gárate Calderón, Valentina; Crovari Eulufi, Fernando; Jiménez Fonseca, Paula; Carmona Bayonas, Alberto; Zwenger, Ariel; Armisen, Ricardo; Corválan, Alejandro H.; Garrido Salvo, Marcelo; Owen, Gareth Ivor; Pinto, Mauricio P.; Retamal, Ignacio N.; Fernández, María F.; Cisternas, Betzabe; Mondaca, Sebastián; Sánchez Rojel, César Giovanni; Galindo Aranibar, Héctor Gonzalo; Nervi, Bruno; Ibáñez Cáceres, Carolina; Acevedo Claros, Francisco Nicolás; Madrid, Jorge; Peña, José; Bravo, María, Loreto; Maturana, María, José; Córdova Delgado, Miguel; Romero, Diego; De la Jara, Nathaly; Torres, Javiera; Rodríguez Fernández, María; Espinoza Sepúlveda, Manuel Antonio; Balmaceda, Carlos; Freire, Matías; Gárate Calderón, Valentina; Crovari Eulufi, Fernando; Jiménez Fonseca, Paula; Carmona Bayonas, Alberto; Zwenger, Ariel; Armisen, Ricardo; Corválan, Alejandro H.; Garrido, Marcelo
- ItemChilean Registry for Neuroendocrine Tumors: A Latin American Perspective(2019) Pinto, Mauricio P.; Muñoz Medel, Matías; Carrillo, Diego; Retamal, Ignacio N.; Bravo Castillo, María Loreto; Nervi Nattero, Bruno; Sánchez Rojel, César Giovanni; Galindo A., Héctor; Ibáñez Cáceres, Carolina; Peña Durán, José Esteban; Madrid Arenas, Jorge; Valenzuela, Yasna; Balmaceda, Carlos; Briones, Juan; Torres Montes, Paula Javiera; Nilo, Flavia; Guarda Vega, Francisco; Quintana, Juan Carlos; Orellana, Pilar; Mondaca Contreras, Sebastián Patricio; Acevedo Claros, Francisco Nicolás; Vicentini, Daniel; Córdova Delgado, Miguel; Owen, Gareth Ivor; Garrido Salvo, Marcelo
- ItemExamen de detección de virus papiloma humano en el tamizaje de cáncer cervicouterino en un Servicio de Salud de Santiago, Chile(2015) Terrazas, Solana; Ibáñez Cáceres, Carolina; Lagos, Marcela; Poggi, Helena; Brañes, Jorge; Barriga Cosmelli, María Isabel; Cartagena, Jaime; Núñez, Felipe; González, Francisca; Cook, María Paz; Van De Wyngard, Vanesa; Ferreccio Readi, Catterina; Terrazas, Solana; Ibáñez Cáceres, Carolina; Lagos, Marcela; Poggi, Helena; Brañes, Jorge; Barriga, María I.; Cartagena, Jaime; Núñez, Felipe; González, Francisca; Cook, María Paz; Van De Wyngard, Vanesa; Ferreccio Readi, Catterina
- ItemHigh linoleic acid levels in red blood cells predict a poor response to neoadjuvant chemotherapy in human epidermal growth factor receptor type 2-positive breast cancer patients(2024) Rodrigo Valenzuela; Walbaum García, Benjamín Vicente; Farías Castro, Camila ; Acevedo Claros, Francisco Nicolás; Vargas Añazco, Catalina Andrea; Bennett Lason, José Tomás; Bravo, M. Loreto; Pinto, Mauricio P.; Medina Araya, Lidia Marjorie; Merino Lara, Tomás Rodrigo; Ibáñez Cáceres, Carolina; Parada Daza, Alejandra Cristina; Sánchez Rojel, César GiovanniObjective Polyunsaturated fatty acids are categorized as ω-3 or ⍵-6. Previous studies demonstrate that breast cancers display a high expression of fatty acid synthase and high fatty acid levels. Our study sought to determine if changes in plasma or red blood cell membrane fatty acid levels were associated with the response to preoperative (neoadjuvant) chemotherapy in non-metastatic breast cancer patients.MethodsOur prospective study assessed fatty acid levels in plasma and red blood cell membrane. Response to neoadjuvant chemotherapy was evaluated by the presence or absence of pathologic complete response and/or residual cancer burden.ResultsA total of 28 patients were included. First, patients who achieved pathologic complete response had significantly higher neutrophil-to-lymphocyte ratio versus no pathologic complete response (P = 0.003). Second, total red blood cell membrane polyunsaturated fatty acids were higher in the absence of pathologic complete response (P = 0.0028). Third, total red blood cell membrane ⍵-6 polyunsaturated fatty acids were also higher in no pathologic complete response (P < 0.01). Among ⍵-6 polyunsaturated fatty acids, red blood cell membrane linoleic acid was higher in the absence of pathologic complete response (P < 0.01). Notably, plasma polyunsaturated fatty acid, ⍵-6, and linoleic acid levels did not have significant differences. A multivariate analysis confirmed red blood cell membrane linoleic acid was associated with no pathologic complete response; this was further confirmed by receiver operating characteristic analysis (specificity = 92.3%, sensitivity = 76.9%, and area under the curve = 0.855).ConclusionsPending further validation, red blood cell membrane linoleic acid might serve as a predictor biomarker of poorer response to neoadjuvant chemotherapy in non-metastatic human epidermal growth factor receptor type 2–positive breast cancer. Measuring fatty acids in red blood cell membrane could offer a convenient, minimally invasive strategy to identifying patients more likely to respond or those with chemoresistance.
- ItemHPV vaginal self-sampling among women non-adherent to Papanicolaou screening in Chile(2013) Léniz Martelli, Javiera; Barriga Cosmelli, María Isabel; Lagos Lucero, Marcela; Ibáñez Cáceres, Carolina; Puschel Illanes, Klaus; Catterina Ferreccio
- ItemImpact of Adjuvant FOLFOX on Quality of Life and Peripheral Neuropathy Incidence in Patients With Gastric Cancer: A Prospective Cohort Study(Elsevier Inc., 2023) Mondaca Contreras, Sebastián Patricio; Pinto, Mauricio P.; Briones Carvajal, Juan Rodrigo; Caire, Nicole; Peña Prado, José Tomas; Koch Hein, Erica Cristina; Muñiz Muñoz, Maria Sabrina; Herrera, María Elisa; Sanchez Rojel, Cesar Giovanni; Galindo Aranibar, Héctor Gonzalo; Pizarro Brito, Gonzalo Ignacio; Acevedo Claros, Francisco Nicolas; Ibáñez Cáceres, Carolina; Balmaceda Araque, Carlos Felipe; Norero, Enrique; Duran, Doris; Garrido Salvo, Marcelo Adán; Nervi Nattero, BrunoObjectives: Perioperative and adjuvant chemotherapy have demonstrated clinical benefits in localized gastric cancer. Nevertheless, the reports on their effects on patient's health-related quality of life (HRQoL) are scarce. Here, we prospectively assessed quality of life and the incidence of chemotherapy-induced peripheral neuropathy (CIPN) in a cohort of patients treated with adjuvant FOLFOX. Methods: Localized stomach or gastroesophageal junction adenocarcinoma patients who underwent curative resection were recruited at a single center. All patients received adjuvant FOLFOX6, and HRQoL and CIPN were assessed using the European organization for research and treatment of cancer quality life (EORTC) C30 and the EORTC CIPN20 questionnaires, respectively. Clinically significant deterioration of HRQoL was also assessed as a coprimary outcome in a longitudinal analysis. Results: We recruited a total of 63 patients. Median age was 62.5 years, and 75% had stomach tumors. Twenty-four weeks after the start of treatment, the probability of being free from HRQoL deterioration and CIPN was 29% (95% confidence interval [CI] 18%-42%) and 6% (95% CI 2%-17%), respectively. Five-year disease-free survival was 45% (95% CI 24%-64%) and 5-year overall survival was 63% (95% CI 48%-76%). Conclusions: Adjuvant FOLFOX is associated with a high rate of long-term survival in localized gastric cancer; nevertheless, it has detrimental effects on patients’ quality of life.
- ItemIn vitro cell response to chemotherapeutic agents, to personalize ovarian cancer treatment : report of two cases(2013) Ibáñez Cáceres, Carolina; Garrido Salvo, Marcelo; Medina, L.; Kato Cardemil, Sumie Rode; Bravo Castillo, María Loreto; González, P.; Oliva, B.; Pizarro, J.; Bustamante, E.; Brañes, Jorge; Cuello F., Mauricio; Owen, Gareth Ivor
- ItemLeptin promotes a more aggressive behavior of ovarian cancer cells : a potential explanation for a worse prognosis in obese ovarian cancer patients(2015) Cuello F., Mauricio; Kato Cardemil, Sumie Rode; Abarzúa Catalán, L.; Delpiano, A.; García, K.; Sanhueza, C.; Ibáñez Cáceres, Carolina; Brañes Yunusic, Jorge Antonio; Castellón E.; Owen, Gareth Ivor; Trigo, C.
- ItemLeptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells : an explanation for poor outcomes in obese women(2015) Kato Cardemil, Sumie Rode; Abarzúa Catalán, Lorena; Trigo, César; Delpiano, Ana; Sanhueza, Cristobal; García, Karen; Ibáñez Cáceres, Carolina; Hormazábal, Katherine; Díaz Bórquez, Daniela Aida; Brañes Yunusic, Jorge Antonio; Castellón, Enrique; Bravo, Erasmo; Owen, Gareth Ivor; Cuello F., Mauricio
- ItemMetformin, at concentrations corresponding to the treatment of diabetes, potentiates the cytotoxic effects of carboplatin in cultures of ovarian cancer cells(2013) Erices, R.; Bravo Castillo, María Loreto; González, P.; Oliva, B.; Racordon, D.; Garrido Salvo, Marcelo; Ibáñez Cáceres, Carolina; Kato Cardemil, Sumie Rode; Brañes, Jorge; Pizarro, J.; Barriga, M. I.; Barra, A.; Bravo, E.; Alonso, C.; Bustamante, E.; Cuello F., Mauricio; Owen, Gareth Ivor
- ItemMulti-Objective Optimization for Personalized Prediction of Venous Thromboembolism in Ovarian Cancer Patients(2020) Fresard, M. E.; Erices Vidal, Rafaela Miguelina; Bravo Castillo, Maria Loreto; Cuello F., Mauricio; Owen, Gareth Ivor; Ibáñez Cáceres, Carolina; Rodríguez Fernández, María
- ItemPalbociclib in advanced stage hormone receptor-positive breast cancer: real- world data from a Chilean multicentre registry(2023) Walbaum García, Benjamín Vicente; Reyes, José Miguel ; Rodríguez, Pablo ; Muñiz Muñoz, María Sabrina; Medina Araya, Lidia Marjorie; Ibáñez Cáceres, Carolina; Merino Lara, Tomás Rodrigo; Pinto, Mauricio ; Bravo, María Loreto ; Acevedo Claros, Francisco Nicolás; Bennett Laso, José Tomás; Sánchez Rojel, César GiovanniBackground The addition of cyclin-dependent kinases inhibitors (CDKi) to endocrine therapy (ET) as the first- or second line treatment improves progression-free and overall survival (OS) in hormone receptor-positive, HER2 negative (HR+/HER2-) advanced stage breast cancer (ABC). Our study compared survival rates and prognostic factors in Chilean patients that used palbociclib as first or subsequent (≥second) lines of treatment in a real-world setting.Methods Our retrospective population-cohort study included HR+/HER2- ABC patients. We calculated 5-year OS and performed a multivariate analysis to determine prognostic factors.Results A total of 106 patients were included. Median age was 49 years (19–86), 28.3% (30) had de novo stage IV disease; 63% received palbociclib with ET as first line, 54% of them with aromatase inhibitor over fulvestrant. Median OS for the entire cohort was 99 months and 5-year OS was 69%. Patients that received first line palbociclib had a 5-year OS of 89% versus 43% for ET monotherapy or ≥second line palbociclib (p = 0.0062). Multivariate analysis showed that the year at diagnosis and CDKi timing (first line versus ≥second line) were significantly associated with OS.Conclusion Our real-world data show that first-line CDKi + ET provides a statistically significant benefit in OS versus ≥second line in HR+/HER2- ABC patients.
- ItemScreening trial of human papillomavirus for early detection of cervical cancer in Santiago, Chile(2013) Ferreccio Readi, Catterina; Barriga Cosmelli, María Isabel; Lagos Lucero, Marcela; Ibáñez Cáceres, Carolina; Poggi, Helena; González, F.; Terrazas Martins, Solana; Katki, H.; Núñez, F.; Cartagena, J.; Van De Wyngard, V.; Vinales, D.; Brañes, Jorge
- ItemSuboptimal use of ovarian function suppression in very young women with early breast cancer: a real-world data study(2024) Heredia Castro, Ana Manuela; Walbaum García, Benjamín Vicente; Vidal, María ; Itriago Giménez, Laura Morella; Camus Appuhn, Mauricio Gonzalo; Domínguez Covarrubias, Francisco José; Manzor, Manuel ; Martínez, Raúl ; Murature, Geraldine ; Muñiz Muñoz, María Sabrina; Navarro, Marisel ; Guerra, Constanza ; Merino Lara, Tomás Rodrigo; Medina Araya, Lidia Marjorie; Ibáñez Cáceres, Carolina; Ramírez Parada, Karol Lilia; Acevedo Claros, Francisco Nicolás; Sánchez Rojel, César GiovanniPurpose The incidence of breast cancer in young women (BCYW) has increased in recent decades. Malignant disease in this subset is characterized by its aggressiveness and poor prognosis. Ovarian function suppression (OFS) in these patients improves survival especially in hormone receptor-positive (HR +) cases. The Regan Composite Risk (RCR) is a prognostic tool to identify high-risk HR + BC candidates for OFS. Our study sought to characterize a Chilean cohort of early HR + BCYW assessing the use of OFS and its related prognosis and the utility of RCR in our patients.MethodsThis was a retrospective population cohort study that included ≤ 35-year-old early HR + /human epidermal growth factor receptor 2 -negative (HER2-) BC patients treated between 2001 and 2021. Analysis included clinical-pathological characteristics, treatment strategies, and survival. Also, we evaluated the association between RCR and survival.ResultsA total of 143 patients were included into our study, representing 2.9% of all early BC cases in our registry. Median age was 31 years old (range: 19–35). Most patients (93%) received endocrine therapy (ET). Of these, 18% received OFS. No survival differences were observed among treatment strategies. Median RCR score for patients treated with CT plus ET was significantly higher vs. ET alone (2.95 vs. 1.91; p = 0.0001). Conversely, patients treated with tamoxifen alone had significantly lower RCR scores vs. OFS (2.72 vs. 3.14; p = 0.04). Higher RCR scores were associated with poorer overall survival.ConclusionLess than 20% of very young women with early HR + /HER2-BC in our cohort received OFS, in most cases, this involved surgical oophorectomy. RCR score was higher in patients that underwent CT and OFS and was associated with survival, regardless of treatment. We confirm the RCR score as a valuable prognostic tool to identify high-risk BC patients who could benefit from OFS.
- ItemUpper-Limb Disability and the Severity of Lymphedema Reduce the Quality of Life of Patients with Breast Cancer-Related Lymphedema(2023) Ramirez Parada, Karol Lilia; González Santos, Angela ; Riady Aleuy, Layla ; Pinto, Mauricio P.; Ibáñez Cáceres, Carolina; Merino Lara, Tomás Rodrigo; Acevedo Claros, Francisco Nicolás; Walbaum García, Benjamín Vicente; Fernández Verdejo, Rodrigo ; Sánchez Rojel, César GiovanniBreast cancer-related lymphedema (BCRL) is characterized by arm swelling, pain, and discomfort, reducing the quality of life (QoL) of affected individuals. BRCL is caused via the blockage or disruption of the lymphatic vessels following cancer treatments, leading to an accumulation of fluid in the affected arm. While current BCRL rehabilitation treatments seek to reduce arm swelling, our study aimed to examine the impact of both the magnitude of lymphedema (ΔVolume) and arm disability on three dimensions of QoL: social, physical, and psychological. Using the Disabilities of the Arm, Shoulder, and Hand questionnaire (DASH) and the Upper Limb Lymphedema 27 questionnaire (ULL) in a group of 30 patients, we found that the magnitude of lymphedema (ΔVolume) was associated with the social dimension of QoL (r = 0.37, p = 0.041), but not with other dimensions. On the other hand, arm disability was associated with all evaluated dimensions of QoL (social, physical, and psychological: p < 0.001, p = 0.019, and p = 0.050 (borderline), respectively). These findings suggest that BCRL rehabilitation strategies should not only aim to reduce the magnitude of lymphedema but should also seek to improve or preserve arm functionality to enhance the QoL of BCRL patients.