Browsing by Author "Hodgson Bunster, María Isabel"

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    Association between eating behavior scores and obesity in Chilean children
    (2011) Santos Martín, José Luis; Ho-Urriola, Judith A.; González, Andrea; Smalley Meylan, Susan Valerie; Domínguez-Vásquez, Patricia.; Cataldo Bascuñan, Luis Rodrigo; Obregón, Ana M.; Amador, Paola.; Weisstaub, Gerardo.; Hodgson Bunster, María Isabel
    Abstract Background Inadequate eating behavior and physical inactivity contribute to the current epidemic of childhood obesity. The aim of this study was to assess the association between eating behavior scores and childhood obesity in Chilean children. Design and methods We recruited 126 obese, 44 overweight and 124 normal-weight Chilean children (6-12 years-old; both genders) according to the International Obesity Task Force (IOTF) criteria. Eating behavior scores were calculated using the Child Eating Behavior Questionnaire (CEBQ). Factorial analysis in the culturally-adapted questionnaire for Chilean population was used to confirm the original eight-factor structure of CEBQ. The Cronbach's alpha statistic (>0.7 in most subscales) was used to assess internal consistency. Non-parametric methods were used to assess case-control associations. Results Eating behavior scores were strongly associated with childhood obesity in Chilean children. Childhood obesity was directly associated with high scores in the subscales "enjoyment of food" (P < 0.0001), "emotional overeating" (P < 0.001) and "food responsiveness" (P < 0.0001). Food-avoidant subscales "satiety responsiveness" and "slowness in eating" were inversely associated with childhood obesity (P < 0.001). There was a graded relation between the magnitude of these eating behavior scores across groups of normal-weight, overweight and obesity groups. Conclusion Our study shows a strong and graded association between specific eating behavior scores and childhood obesity in Chile.
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    Bone mineral density in young Chilean patients with type 1 diabetes mellitus
    (2016) Mossoa, C.; Hodgson Bunster, María Isabel; Ortiz, T.; Reyes G, L.
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    Clinical profile of children with diabetic ketoacidosis in fifteen years of management in a Critical Care Unit
    (2018) Del Pozo Bascuñan, Paulina Andrea; Aránguiz, Diego; Córdova Lazo, Guiliana; Scheu Goncalves, Christian Andrés; Valle Múñoz, Patricio Alejandro; Cerda, Jaime; García Bruce, Hernán; Hodgson Bunster, María Isabel; Castillo Moya, Andres Eduardo
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    Clusters of Autoimmune Diseases in Children and the Role of PTPN22 C1858T Gene Polymorphism in Pediatric Polyautoimmunity
    (2014) Borzutzky Schachter, Arturo; Seiltgens, Cristián; Iruretagoyena B., Mirentxu; Cristi, Francisca; Ponce, María Jesús ; Melendez, Patricia; Martínez Aguayo, Alejandro; Hodgson Bunster, María Isabel; Talesnik Guendelman, Eduardo; Riera Cassorla, Francisca Paz; Méndez, Cecilia; Harris D., Paul R.; García Bruce, Hernán; Gana Ansaldo, Juan Cristóbal; Godoy, Claudia; Cattani Ortega, Andreína
    Background/Purpose:Autoimmune diseases (AIDs) have familial aggregation and frequently share a common genetic background, but few studies have evaluated autoimmune clusters in children with AIDs and their families. Children with more than one AID (pediatric polyautoimmunity) may have a stronger genetic component than children with a single AID. The objectives of this study were to identify clusters of AIDs in children and their first-degree relatives and to evaluate the association of PTPN22 C1858T gene polymorphism with pediatric polyautoimmunity.Methods:A cross-sectional study was performed in subjects with an AID of pediatric onset (<18 years)recruited at Pediatric Rheumatology, Endocrinology and Gastroenterology Clinics at the Health Network of the Pontificia Universidad Católica de Chile School of Medicine. Clusters of AIDs were identified by K-means cluster analysis. The PTPN22 C1858T gene polymorphism was determined by RT-PCR in subjects with pediatric polyautoimmunity and in subjects with three common AIDs: juvenile idiopathic arthritis (JIA), autoimmune thyroid disease (AITD), and type I diabetes (T1D).Results:191 subjects with pediatric AIDs were included, of which 45 (24%) had polyautoimmunity. Mean age was 12.1 years (range 1–19) and 68% were female. Most frequent AIDs were JIA (36%), AITD (25%), T1D (19%), uveitis (8%), celiac disease (6%), and vitiligo (6%). 59% of subjects with pediatric autoimmunity had first-degree relatives with an AID. Five clusters of AID were identified in families of children with autoimmunity (Table 1). Among the 45 subjects with pediatric polyautoimmunity, four clusters of AIDs were identified (Table 2). Genomic DNA from 128 subjects was evaluated for PTPN22 C1858T gene polymorphism revealing common homozygosity (C/C) in 85.2%, heterozygosity (C/T) in 13.3%, and rare homozygosity (T/T) in 1.6 %, in equilibrium with Hardy Weinberg equation (P = 0.4). 26% of polyautoimmune subjects had the T allele in contrast with 11% of monoautoimmune subjects (P = 0.04). No significant difference was found in the age of onset of autoimmunity between mono and polyautoimmune subjects (P = 0.44) or between subjects with C/C genotype vs. C/T and T/T genotypes (P = 0.81).
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    Cortisol y amilasa salival en niñas: variación según la curva diurna, la ingesta de alimentos y la actividad física. Diurnal variation of salivary cortisol and α amylase levels in normal girls. Effects of meals and physical exercise
    (2015) Araya, S.; Cataldo Bascuñan, Luis Rodrigo; Calderon, C.; Weisstaub, G.; Parada, J.; Hodgson Bunster, María Isabel; Santos Martín, José Luis
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    D-lactoacidosis como Complicación del Síndrome de Intestino Corto
    (2010) Arancibia Assael, Gabriel; Hodgson Bunster, María Isabel; Harris D., Paul R.
    Short bowel syndrome is defined as the loss, congenital or acquired, anatomical or functional, of a large part of the small intestine that generates inadequate absorption of nutrients and the frequent need of prolonged parenteral nutrition. The etiology of short bowel is diverse and varies with age. The necrotizing enterocolitisis and the midgut volvulus are among the most frequent causes. The bacterial overgrowth is frequently observed in children with short bowel, due to the secondary dilation of the remaining small bowel and to the associated intestinal dysmotility. It is more frequent in absence of the ileocecal valve. We present a 6 year old boy with short bowel syndrome secondary to extensive intestinal resection after a volvulous of the medium small intestine, 9 months before admission to the hospital, and who was on cyclical parenteral nutrition at home. The child developed ataxia, disarthria, dizziness and conscience compromise been admitted to de intensive care unit in deep sopor. An extensive work up including metabolic, infectious, toxicology and SNC imaging was negative except for metabolic acidosis. He was discharged on good conditions. Even though the child was on supportive therapy, the patient was readmitted few hours later with similar symptoms. D-lactoacidosis was suspected and confirmed with a value of 6.69 mmol/l (normal range: 0,0-0,25). Literature about this uncommon complication and its mechanism is reviewed. D-lactoacidosis should be suspected in every patient with short bowel syndrome and unexplained metabolic acidosis associated with neurologic symptoms.
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    Diagnóstico y tratamiento de las dislipidemias en niños y adolescentes : recomendaciones de la Rama de Nutrición de la Sociedad Chilena de Pediatría
    (2014) Barja Y., Salesa; Cordero Bayon, María Luisa; Baeza, C.; Hodgson Bunster, María Isabel
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    Dietary intake, body composition, and physical activity among young patients with type 1 diabetes mellitus
    (2015) Mosso, C.; Halabi, V.; Ortiz, T.; Hodgson Bunster, María Isabel
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    Estimación de la talla en la evaluación nutricional de niños con parálisis cerebral
    (2014) Amezquita García, María Virginia; Hodgson Bunster, María Isabel
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    Estimación de masa grasa en niños chilenos: ecuaciones de pliegues subcutáneos vs densitometría de doble fotón
    (2011) Urrejola, P.; Hernández C, I.; Icaza N, G.; Velandia, S.; Reyes G, L.; Hodgson Bunster, María Isabel
    La estimación del grosor de pliegues subcutáneos (PS) es una manera simple de estimar composición corporal en niños, sin embargo, tiene limitaciones. La densitometría de doble fotón (DXA) es considerada como el nuevo estándar de referencia. Objetivo: Comparar la precisión de la estimación del porcentaje de masa grasa por PS con la obtenida por DXA en población infantil chilena. Pacientes y Método: Se estimó el porcentaje de masa grasa en 128 niños (70 mujeres y 58 hombres) sanos, eutróficos, entre 2 y 18 años, por diversas ecuaciones de PS y se comparó con DXA. La diferencia entre ambos mediciones fue evaluada mediante el método de Bland y Altman y el coeficiente de concordancia de Lin. Resultados: La mayoría de las ecuaciones de PS tuvieron un pobre nivel de concordancia con DXA. Sin embargo, existe una mejor concordancia entre lo calculado según PS y DXA tanto en niños pre-puberales con la fórmula específica de Westrate y Deurenberg y en niños de todas las edades, con la ecuación general de Westrate y Deurenberg (diferencia promedio de 2,96 ± 1,20% y 4,92 ± 0,98% e índice de concordancia de Lin de 0,50 ± 0,22 y 0,43 ± 0,88, respectivamente) Conclusiones: La estimación del porcentaje de masa grasa a partir de los PS, tiene una baja concordancia, sin embargo, mientras no se desarrollen ecuaciones con una precisión más alta se podrían utilizar las ecuaciones de Westrate y Deurenberg a todas las edades y la de Westrate y Deurenberg específica para la edad pre-puberal.
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    Evaluación nutricional en niños hospitalizados en un Servicio de Pediatría
    (2016) Velandia, S.; Hodgson Bunster, María Isabel; Le Roy, Catalina
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    Gestational diabetes and pre-pregnancy overweight: Possible factors involved in newborn macrosomia
    (2012) Olmos Coelho, Pablo Roberto; Borzone, Gisella; Olmos Borzone, Roberto Ignacio; Valencia, Claudio Nicolás; Bravo, Felipe Andrés; Hodgson Bunster, María Isabel; Belmar Jones, Cristián Gastón; Poblete Lizana, José Andrés; Escalona, Manuel Orlando; Gómez, Bernardita
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    Glycemic Response after Starch Consumption in Relation to Salivary Amylase Activity and Copy-number Variation of AMY1 Gene
    (2015) Alberti, Gigliola; Parada, Javier; Rodrigo Cataldo, L.; Vega, Javier; Aguilera, Concepción M.; Alvarez-Mercado, Ana I.; Hodgson Bunster, María Isabel; López, Alberto; Angellotti, Isidora; Gil, Angel; Santos Martín, José Luis
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    Home parenteral nutrition in pediatric patients with intestinal insufficiency
    (2019) Zapata, Yazmín; Hodgson Bunster, María Isabel; Cordero Bayon, María Luisa; Rodriguez Osiac, Lorena; Cerda, Jaime
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    Melanocortin-4 Receptor Gene Variation Is Associated with Eating Behavior in Chilean Adults
    (2016) Vega, Javier; Salazar, G.; Hodgson Bunster, María Isabel; Cataldo Bascuñan, Luis Rodrigo; Valladares, M.; Obregon, A.; Santos Martín, José Luis
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    Melanocortin-4 receptor polymorphism rs17782313 : Association with obesity and eating in the absence of hunger in Chilean children
    (2014) Ho-Urriola, J.; Guzman-Guzman, I.; Smalley Meylan, Susan Valerie; Gonzalez, A.; Weisstaub, G.; Dominguez-Vasquez, P.; Valladares, M.; Amador, P.; Hodgson Bunster, María Isabel; Obregon, A.M.; Santos Martín, José Luis
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    National concensus in cystic fibrosis
    (SOCIEDAD CHILENA DE PEDIATRIA, 2001) Sánchez Díaz, Ignacio; Pérez Hernández, María Angélica; Boza Costagliola, María Lina; Lezana S., Viviana; Vila I., M. Alejandra; Repetto Lisboa, María Gabriela; Hodgson Bunster, María Isabel; Ríos M., Gloria
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    Plasma levels of interleukin-6 and interleukin-18 after an acute physical exercise : relation with post-exercise energy intake in twins
    (2013) Almada, C.; Cataldo Bascuñan, Luis Rodrigo; Smalley Meylan, Susan Valerie; Díaz, E.; Serrano Reyes, Andrés; Hodgson Bunster, María Isabel; Santos Martín, José Luis
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    Polimorfismos genéticos de interleuquina 6 (IL6), IL6R e IL18 : asociación con componentes del síndrome metabólico en niños chilenos con obesidad
    (2014) Suazo, José; Smalley Meylan, Susan Valerie; Hodgson Bunster, María Isabel; Weisstaub, Gerardo; González, Andrea; Santos Martín, José Luis
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    Prevalence of metabolic syndrome in obese Chilean children and association with gene variants of the leptin-melanocortin system
    (2013) Suazo, José; Hodgson Bunster, María Isabel; Weisstaub, G.; Amador, P.; Santos Martín, José Luis