Browsing by Author "Harris Diez, Paul Richard"
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- ItemA Comprehensive Review of the Natural History of Helicobacter Pylori Infection Children(2000) Harris Diez, Paul Richard; Atherton, J; Gold, B; Goodman, K; Guarner, J; Madrazo de la Garza, A; Muñoz, O; Pérez-Pérez, G; Torres, J
- ItemAnswer to Dr. Rinaldo Pellicano's letter about the article “Maternal infection due to Helicobacter pylori does not increase the risk of the infection in the first trimester of the life of their infants”Respuesta a la carta del Dr. Rinaldo Pellicano con relación al artículo “La infección materna por Helicobacter pylori no aumenta el riesgo de contraer la bacteria en el primer trimestre de vida de sus lactantes”(Sociedad Chilena de Pediatria, 2016) Troncoso Trujillo, Paula Andrea; Harris Diez, Paul Richard
- ItemAttenuated Salmonella typhimurium encoding the HpaA antigen of Helicobacter pylori elicit a Th1 and Th2 immune response(2007) Serrano Honeyman, Carolina Andrea; Olmos, Marco; Bruce, Elsa; Martinez, Patricio; Torres, Javiera; Venegas, Alejandro; Harris Diez, Paul Richard
- ItemAutonomic effect of water ingestion in postural tachycardia syndrome(2007) Taneja, Indu; Raj, Satish R.; Harris Diez, Paul Richard; Byrne, Daniel; Jordan, Jens; Robersons, David
- ItemChildhood cholelithiasis in a high prevalent population(2007) Harris Diez, Paul Richard; Chateau Infante Bernardita; Miquel Poblete, Juan FranciscoBile duct disease and gallstone (cholelithiasis) have been considered an uncommon cause of acute abdominal pain in children compared to adults. However, there are significant differences with the adult gallstone disease: increased proportion of patients with an underlying condition, higher incidence of acalculous cholecystitis and lower frequency of choledocolithiasis. With ultrasound examination, it is possible to detect early gallstone in the fetal period and in asymptomatic patients, explaining the increase in gallstone incidence. This disease is more common than suggested in western literature and its diagnosis is increasing as well. The high prevalence of gallstone in adult population in Chile creates an ideal setting for cholesterol and gallstone candidate gene testing. Although the clinical diagnosis of gallstone is simple, there is no consensus about the best therapy in children, explained partially by the lack of knowledge of the natural history of the disease. The role of gallstone disease acquired early in life in gallbladder carcinoma deserves special attention.
- ItemClusters of Autoinmune Diseases in Children(KARGER, 2016) Seiltgens, Sorrel Cristian; Iruretagoyena Bruce, Mirentxu Ines; Melendez Escobar, Patricia Eugenia; Ponce Arqueros, Maria Jesus; Talesnik Guendelman, Eduardo; Méndez Rivera, Cecilia Del Pilar; Godoy Cortes, Claudia Loreto; Martinez Aguayo, Alejandro Gregorio; Hogdson, Isabel; Harris Diez, Paul Richard; Gana, Juan Cristobal; Riera Cassorla, Francisca Paz; Garcia Bruce, Hernán Gabriel; Cattani Ortega, Andreina; Borzutzky Schachter, Arturo Jose
- ItemEvaluation of the esophageal pH monitoring and its relation with clinical indications: MePeache phase IEvaluación de los índices de monitoreo de pH esofágico y su relación con indicaciones clínicas: MePeache fase I(2007) Saavedra Gutierrez, Silvana Jeanette; Maria Francisca, Jaime Méndez; Gana Ansaldo, Juan Cristóbal; Larrain Barros, Francisco Javier; Guiraldes Camerati, Ernesto Rafael Ramón; Harris Diez, Paul RichardObjectives: Establish mean values and normality range for pH metric parameters, different to reflux index (RI), in esophageal pH monitoring (EpHm) according to new RI cut- off values; besides, correlate them with clinical diagnosis. Method: Retrospective study of EpHm parameters including RI, number and average length of episodes (DPE), number of episodes > 5 minutes and duration of the longest episode. 153 patients were classified according to age (Group I < 1 year and Group II > 1 year) and RI cut-off values: Normal group (NL) with physiological range (RI < 12% GI and < 6% GII) and Pathological group (PT) when RI was higher. Results: The most frequent EpHm indications were gastroesophageal reflux (GER) study (41.7%), airway diseases (19.9%) and otolaryngologic diseases (17.2%). There was no correlation between EpHm parameters in GI (n = 53) when analyzed by gender, referring physician or EpHm indication. In GII (n = 100), the RI for children referred by pediatricians was higher than the one for those referred by gastroenterologists in Group NL (p = 0.002). There were differences in all pH metric parameters according to NL and PT groups, except DPE. 84.9% and 77% of the EpHms in GI and GII respectively were normal. Conclusions: The EpHm parameters allow the division in NL and PT groups according to new RI cut-off values. There is a weak correlation between clinical suspicion and pHmetric diagnosis, sugesting the necessity to reevaluate EpHm indications. © 2007 Sociedad Chilena de Pediatría.
- ItemFood allergy markers in peptic disease(2009) Talesnik Guendelman, Eduardo; Majerson Grinberg, Daniela; Serrano Honeyman, Carolina Andrea; Einisman Fleiderman, Helly Jael; Aravena González, Carmen Fabiola; Peña Villegas, Alfredo Javier; Ros Torres, Javiera Ignacia; Duarte Garcia, De Cortázar Ignacio; Harris Diez, Paul RichardBackground: The double-blind food challenge is the gold standard for diagnosis of food allergy, eventhough it is difficult to standardize and execute. An increase in allergy prevalence worldwide accentuates the importance of evaluating food allergy markers, in order to help the diagnosis. Objective: Elaboration of an operational definition for food hypersensitivity (FH) and evaluate the role of allergy markers, endoscopic and hystological findings, gastric mucosa cytokines and personal/family history of allergy in children. Method: Enrollment of children with suspected peptic disease referred for endoscopy. We obtained antral biopsies for hystological evaluation (eosinophil and mast cell count) and measurement of mucosal cytokines through an ELISA test. Patients were evaluated with Prick test, total serum IgE and clinical questionnaires for allergies. They were divided into two groups; children with and without food hypersensitivity. Results: 97 children were enrolled (mean: 11.7 ± 3, range 3-18). 4% of children had FH. The endoscopic findings did not correlate with the presence of FH. 74.1% of patients without FH had eosinophils in the gastric mucosa compared to groups with FH which had 100% (p < 0.05). Only IL-2 among the evaluated cytokines was found in a greater concentration in patients without FH. 33% of patients considered themselves having history of personal allergies versus 11.8% of people without FH (p < 0.05). Conclusions: 12,4% of children with digestive symptoms referred to endoscopy have FH. There are no clinical, endoscopic or hystological differences between patients with or without FH.
- ItemFunctional gastrointestinal disorders in children from low socio-economic status and Helicobacter pylori infection(2018) Jaime Méndez, María Francisca; Villagrán Torres, Andrea Alejandra; Hernández Rocha, Cristián Antonio; Ortiz Aparicio, Freddy Miguel; Serrano Honeyman, Carolina; Harris Diez, Paul Richard
- ItemHelicobacter pylori Displays Differential Iron Regulated Gene Expression Depending on Iron Status of Their Host(2012) Serrano Honeyman, Carolina Andrea; Villagran Torres, Andrea Alejandra; Cofre Dougnac, Colomba Del Carmen; Álvarez Espinoza, Manuel Alejandro; Venegas, Alejandro; Toledo, Hector; Harris Diez, Paul Richard
- ItemHelicobacter pylori infection in children is associated with a mucosal T regulatory cell response and less severe gastritis than that of adults(2007) Wright, Shelton W.; Smythies, Lesley; Riera Cassorla, Francisca Paz; Espinoza Torres, Javiera Marcela; Novak, Lea; Schmitz, Julia; Lorenz, Robin G.; Serrano Honeyman, Carolina Andrea; Harris Diez, Paul Richard; Smith, Phillip D.
- ItemHelicobacter pylori infection induces a T regulatory response mediated by TGF-B and IL-10 in children, in contrast to the TH1 response characterized by IFN-G observed in adults(2006) Smythies, Lesley; Harris Diez, Paul Richard; Clements, Ronald H.; Mosteller-Barnum, Lisa M.; Perez-Perez, Guillermo; Smith, Phillip D.
- ItemHelicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-γ, gene-deficient mice(2000) Smythies, L.E.; Waites, K.B.; Lindsey, J.R.; Harris Diez, Paul Richard; Ghiara, P.; Smith, P.D.
- ItemHelicobacter pylori-induced TH1-mediated gastric inflammation is exacerbated in interleukin-4, but not interferon-gamma, gene-deficient mice(1999) Smythies, LE; Waites, KB; Lindsey, JR; Harris Diez, Paul Richard; Ghiara, P; Smith, PD
- ItemHemolytic uremic syndrome associated with entamoeba histolytica intestinal infection(2006) Cavagnaro Santa-María, Carlos Felipe; Guzmán, Carla; Harris Diez, Paul RichardAmebiasis secondary to Entamoeba histolytica (E. histolytica) continues to be a major source of morbidity and mortality worldwide, mainly in developing countries. An association between amebic dysentery and hemolytic uremic syndrome (HUS) has been mentioned, but a cause-and-effect relationship has never been confirmed. We report the case of an 11-year-old healthy white female who developed severe bloody diarrhea after drinking contaminated unboiled water, developing classic HUS and requiring acute intermittent hemodialysis. The etiological study confirmed numerous cysts and hematophagous trophozoites of E. histolytica on stool smear, but without evidence of other pathogens. This report contributes to the concept that classic post-diarrheal HUS, usually related to colitis secondary to enterohemorragic Shiga-toxin producing Escherichia coli (E.coli) strains, may be associated with other pathogens, including E. histolytica. Additional information regarding mechanisms of virulence of E. histolytica and host immunological reaction is needed to clarify the temporal association of these two disorders (HUS and amebiasis).
- ItemInteractions between H. pylori and the gastric microbiome: impact on gastric homeostasis and disease(ELSEVIER, 2021) Serrano Honeyman, Carolina Andrea; Harris Diez, Paul Richard; Smith, Phillip D.; Bimczok, DianeLike many seemingly inhospitable environments on our planet, the highly acidic human stomach harbors a diverse bacterial microflora. The best-known member of the human gastric flora, Helicobacter pylori, causes a number of gastric diseases, including peptic ulcer disease and gastric adenocarcinoma. In the absence of H. pylori infection, the gastric microbiota displays some features similar to the oral cavity with Firmicutes the most common phylum, followed by Proteobacteria and Bacteroidetes. When present, H. pylori dominates the gastric microbiome and reduces diversity and composition of other taxa. The composition of the gastric microbiome also is altered in the setting of proton pump inhibitor therapy and gastric neoplasia. This review summarizes foundational and recent studies that have investigated the composition of the human gastric microbiome in a variety of patient groups, with a focus on potential mechanisms involved in regulation of gastric microbial community structure.
- ItemInterleukin-1 beta and Tumor Necrosis Factor-alpha Polymorphisms as Iron Deficiency Risk Markers in Helicobacter pylori-Infected Children(2012) Serrano Honeyman, Carolina Andrea; Villagrán Torres, Andrea Alejandra; Venegas, Alejandro; Toledo, Hector; Crabtree, Jean E.; Harris Diez, Paul Richard
- ItemJournals of Pediatrics Southern Cone: A path of integration,Revistas de pediatría del Cono sur: Un camino de integración(2013) Ugarte P., F.; Schonhaut B., L.; Harris Diez, Paul Richard; Cano SCH, F.
- ItemLa publicación científica en tiempos de COVID-19(2020) Schonhaut B., Luisa; Harris Diez, Paul Richard; Cano Sch., Francisco
- ItemLabor editorial de Andes Pediátrica/Revista Chilena de Pediatría en tiempos de COVID(2022) Schonhaut, Luisa B.; Cano, Francisco; Harris Diez, Paul Richard