Browsing by Author "Guyatt, Gordon H."

Now showing 1 - 12 of 12
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    A practical approach to evidence-based dentistry : VII How to use patient management recommendations from clinical practice guidelines
    (2015) Carrasco Labra, Alonso; Brignardello Petersen, Romina; Glick, Michael; Guyatt, Gordon H.; Neumann Burotto, Gonzalo Ignacio; Azarpazhooh, Amir
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    Completion and publication rates of randomized controlled trials in surgery an empirical study
    (2015) Rosenthal, Rachel; Kasenda, Benjamin; Dell-Kuster, Salome; Von Elm, Erik; You, John; Neumann Burotto, Gonzalo Ignacio; Tomonaga, Yuki; Saccilotto, Ramon; Amstutz, Alain; Bengough, Theresa; Meerpohl, Joerg J.; Stegert, Mihaela; Tikkinen, Kari A. O.; Blümle, Anette; Carrasco-Labra, Alonso; Faulhaber, Markus; Mulla, Sohail; Mertz, Dominik; Akl, Elie A.; Bassler, Dirk; Busse, Jason W.; Ferreira-González, Ignacio; Lamontagne, Francois; Nordmann, Alain; Gloy, Viktoria; Olu, Kelechi K.; Raatz, Heike; Moja, Lorenzo; Ebrahim, Shanil; Schandelmaier, Stefan; Sun, Xin; Vandvik, Per O.; Johnston, Bradley C.; Walter, Martin A.; Burnand, Bernard; Schwenkglenks, Matthias; Hemkens, Lars G.; Bucher, Heiner C.; Guyatt, Gordon H.; Briel, Matthias
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    Evaluating patient values and preferences for thromboprophylaxis decision making during pregnancy: a study protocol
    (2012) Alonso Coello, Pablo.; Neumann Burotto, Gonzalo Ignacio; Ebrahim, Shanil; Guyatt, Gordon H.; Tikkinen, Kari A.; Eckman, Mark H.; McDonald, Sarah D.; Akl, Elie A.; Bates, Shannon M.
    Abstract Background Pregnant women with prior venous thromboembolism (VTE) are at risk of recurrence. Low molecular weight heparin (LWMH) reduces the risk of pregnancy-related VTE. LMWH prophylaxis is, however, inconvenient, uncomfortable, costly, medicalizes pregnancy, and may be associated with increased risks of obstetrical bleeding. Further, there is uncertainty in the estimates of both the baseline risk of pregnancy-related recurrent VTE and the effects of antepartum LMWH prophylaxis. The values and treatment preferences of pregnant women, crucial when making recommendations for prophylaxis, are currently unknown. The objective of this study is to address this gap in knowledge. Methods We will perform a multi-center cross-sectional interview study in Canada, USA, Norway and Finland. The study population will consist of 100 women with a history of lower extremity deep vein thrombosis (DVT) or pulmonary embolism (PE), and who are either pregnant, planning pregnancy, or may in the future consider pregnancy (women between 18 and 45 years). We will exclude individuals who are on full dose anticoagulation or thromboprophylaxis, who have undergone surgical sterilization, or whose partners have undergone vasectomy. We will determine each participant's willingness to receive LMWH prophylaxis during pregnancy through direct choice exercises based on real life and hypothetical scenarios, preference-elicitation using a visual analog scale (“feeling thermometer”), and a probability trade-off exercise. The primary outcome will be the minimum reduction (threshold) in VTE risk at which women change from declining to accepting LMWH prophylaxis. We will explore possible determinants of this choice, including educational attainment, the characteristics of the women’s prior VTE, and prior experience with LMWH. We will determine the utilities that women place on the burden of LMWH prophylaxis, pregnancy-related DVT, pregnancy-related PE and pregnancy-related hemorrhage. We will generate a “personalized decision analysis” using participants’ utilities and their personalized risk of recurrent VTE as inputs to a decision analytic model. We will compare the personalized decision analysis to the participant’s stated choice. Discussion The preferences of pregnant women at risk of VTE with respect to the use of antithrombotic therapy remain unexplored. This research will provide explicit, quantitative expressions of women's valuations of health states related to recurrent VTE and its prevention with LMWH. This information will be crucial for both guideline developers and for clinicians.
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    Experiences with a novel policy for managing conflicts of interest of guideline developers : a descriptive qualitative study
    (2013) Neumann Burotto, Gonzalo Ignacio; Karl, Renee; Rajpal, Aman; Akl, Elie; Guyatt, Gordon H.
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    Potential impact on estimated treatment effects of information lost to follow-up in randomised controlled trials (LOST-IT): systematic review
    (BMJ PUBLISHING GROUP, 2012) Akl, Elie A.; Briel, Matthias; You, John J.; Sun, Xin; Johnston, Bradley C.; Busse, Jason W.; Mulla, Sohail; Lamontagne, Francois; Bassler, Dirk; Vera, Claudio; Alshurafa, Mohamad; Katsios, Christina M.; Zhou, Qi; Cukierman Yaffe, Tali; Gangji, Azim; Mills, Edward J.; Walter, Stephen D.; Cook, Deborah J.; Schuenemann, Holger J.; Altman, Douglas G.; Guyatt, Gordon H.
    Objective To assess the reporting, extent, and handling of loss to follow-up and its potential impact on the estimates of the effect of treatment in randomised controlled trials.
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    Reporting handling and assessing the risk of bias associated with missing participant data in systematic reviews : a methodological survey
    (2015) Akl, Elie A.; Carrasco Labra, Alonso; Brignardello Petersen, Romina; Neumann Burotto, Gonzalo Ignacio; Johnston, Bradley C.; Sun, Xin; Briel, Matthias; Busse, Jason W; Ebrahim, Shanil; Granados, Carlos; Iorio, Alfonso; Irfan, Affan; Martínez García, Laura; Mustafa, Reem A.; Ramírez Morera, Anggie; Selva, Anna; Solà, Ivan; Sanabria, Andrea Juliana; Tikkinen, Kari A. O.; Vandvik, Per O.; Vernooij, Robin W. M.; Zazueta, Oscar E.; Zhou, Qi; Guyatt, Gordon H.; Alonso Coello, Pablo
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    Reporting missing participant data in randomised trials : systematic survey of the methodological literature and a proposed guide
    (2015) Akl, Elie A.; Shawwa, Khled; Kahale, Lara A.; Agoritsas, Thomas; Brignardello Petersen, Romina; Busse, Jason W.; Carrasco Labra, Alonso; Ebrahim, Shanil; Johnston, Bradley C.; Neumann Burotto, Gonzalo Ignacio; Sola, Ivan; Sun, Xin; Vandvik, Per; Zhang, Yuqing; Alonso Coello, Pablo; Guyatt, Gordon H.
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    Senior GRADE methodologists encounter challenges as part of WHO guideline development panels : an inductive content analysis
    (2016) Alexander, Paul E.; Li, Shelly-Anne; Gionfriddo, Michael R.; Stolzfus, Rebecca; Neumann Burotto, Gonzalo Ignacio; Brito, Juan P.; Djulbegovic, Benjamin; Montori, Víctor M.; Schünemann, Holger J.; Guyatt, Gordon H.
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    Specific instructions for estimating unclearly reported blinding status in randomized trials were reliable and valid
    (ELSEVIER SCIENCE INC, 2012) Akl, Elie A.; Sun, Xin; Busse, Jason W.; Johnston, Bradley C.; Briel, Matthias; Mulla, Sohail; You, John J.; Bassler, Dirk; Lamontagne, Francois; Vera, Claudio; Alshurafa, Mohamad; Katsios, Christina M.; Heels Ansdell, Diane; Zhou, Qi; Mills, Ed; Guyatt, Gordon H.
    Objective: To test the reliability and validity of specific instructions to classify blinding, when unclearly reported in randomized trials, as "probably done" or "probably not done."
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    Spotlight : Patient Centred Care Decision aids that really promote shared decision making : the pace quickens
    (2015) Agoritsas, Thomas; Heen, Anja Fog; Brandt, Linn; Alonso Coello, Pablo; Kristiansen, Annette; Akl, Elie A.; Neumann Burotto, Gonzalo Ignacio; Tikkinen, Kari; Van der Weijden, Trudy; Elwyn, Glyn; Montori, Victor M.; Guyatt, Gordon H.; Vandvik, Per Olav
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    Women's values and preferences and health state valuations for thromboprophylaxis during pregnancy : A cross-sectional interview study
    (2016) Bates, Shannon M.; Alonso Coello, Pablo; Tikkinen, Kari A. O.; Ebrahim, Shanil; Cruz Lopes, Luciane; McDonald, Sarah D.; Qi Zhou; Akl, Elie A.; Neumann Burotto, Gonzalo Ignacio; Jacobsen, Anne Flem; Yuqing Zhang; Santamaría, Amparo; Annichino Bizzacchi, Joyce Maria; Morten Sandset, Per; Bitar, Wael; Eckman, Mark H.; Guyatt, Gordon H.
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    Women’s Values and Preferences for Thromboprophylaxis during Pregnancy : A Comparison of Direct-choice and Decision Analysis using Patient Specific Utilities
    (2015) Eckman, Mark H.; Alonso-Coello, Pablo; Guyatt, Gordon H.; Ebrahim, Shanil; Tikkinen, Kari A.O.; Lopes, Luciane Cruz; Neumann Burotto, Gonzalo Ignacio; Mcdonald, Sarah D.; Zhang, Yuqing; Zhou, Qi; Akl, Elie A.; Jacobsen, Ann Flem; Santamaría, Amparo; Annichino-Bizzacchi, Joyce Maria; Bitar, Wael; Sandset, Per Morten; Bates, Shannon M.