Browsing by Author "González Aramundiz, José Vicente"
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- ItemDesign of chitosan nanocapsules with compritol 888 ATO (R) for imiquimod transdermal administration. Evaluation of their skin absorption by raman microscopy(2020) Alvarez Figueroa, María Javiera; Narvaez Araya, D.; Armijo Escalona, Nicolás Andrés; Carrasco Flores, E. A.; González Aramundiz, José Vicente
- ItemDifferent Safety Pattern of an Inactivated SARS-CoV-2 Vaccine (CoronaVac®) According to Age Group in a Pediatric Population from 3 to 17 Years Old, in an Open-Label Study in Chile(2023) Le Corre, Nicole; Abarca Villaseca, Katia; Astudillo, Patricio André; Potin Santander, Marcela Patricia; López, Sofía; Goldsack, Macarena; Valenzuela Guerrero, Vania; Schilling Redlich, Andrea; Gaete, Victoria; Rubio, Lilian; Calvo, Mario; Twele, Loreto; González, Marcela; Fuentes, Daniela; Gutiérrez Muñoz, Valentina José; Reyes Zaldivar, Felipe Tomás; Tapia, Lorena I.; Villena, Rodolfo; Retamal Díaz, Angello; Cárdenas, Antonio; Alarcón Bustamante, Eduardo; Xin, Qianqian; González Aramundiz, José Vicente; Álvarez Figueroa, María Javiera; González Muñoz, Pablo Alberto; Bueno Ramírez, Susan; Soto Ramírez, Jorge Andrés; Perret Pérez, Cecilia; Meng, Xing; Kalergis Parra, Alexis MikesDuring the COVID-19 pandemic, the importance of vaccinating children against SARS-CoV-2 was rapidly established. This study describes the safety of CoronaVac® in children and adolescents between 3- and 17-years-old in a multicenter study in Chile with two vaccine doses in a 4-week interval. For all participants, immediate adverse events (AEs), serious AEs (SAEs), and AEs of special interest (AESIs) were registered throughout the study. In the safety subgroup, AEs were recorded 28 days after each dose. COVID-19 surveillance was performed throughout the study. A total of 1139 individuals received the first and 1102 the second dose of CoronaVac®; 835 were in the safety subgroup. The first dose showed the highest number of AEs: up to 22.2% of participants reported any local and 17.1% systemic AE. AEs were more frequent in adolescents after the first dose, were transient, and mainly mild. Pain at the inoculation site was the most frequent AE for all ages. Fever was the most frequent systemic AE for 3–5 years old and headache in 6–17 years old. No SAEs or AESIs related to vaccination occurred. Most of the COVID-19 cases were mild and managed as outpatients. CoronaVac® was safe and well tolerated in children and adolescents, with different safety patterns according to age.
- ItemLower-Sized Chitosan Nanocapsules for Transcutaneous Antigen Delivery(2018) Bussio, Juan I.; Molina-Perea, Carla; González Aramundiz, José Vicente
- ItemOptimization of physicochemical properties of novel multiple nanoemulsion for complex food matrices through iterative mathematical modelling(2020) Cortés Ríos, Javiera Alejandra; Valdivia-Olivares, R. Y.; Alvarez Figueroa, María Javiera; Rodríguez Fernández, María; González Aramundiz, José Vicente
- ItemPassive and iontophoretic transdermal penetration of chlorpromazine(2008) Alvarez Figueroa, María Javiera; González Aramundiz, José Vicente
- ItemPolymeric nanocapsules for vaccine delivery : influence of the polymeric shell on the interaction with the immune system(2018) Peleteiro, M.; Presas, E.; González Aramundiz, José Vicente; Sanchez Correa, B.; Simon Vazquez, R.; Csaba, N.; Alonso, M.; Gonzalez Fernandez, A.
- ItemProtamine Nanocapsules for the Development of Thermostable Adjuvanted Nanovaccines(2018) González Aramundiz, José Vicente
- ItemProtamine-based nanoparticles as new antigen delivery systems(2015) González Aramundiz, José Vicente; Peleteiro Olmedo, Mercedes; González Fernández, África; Alonso Fernández, María José; Stefánia Csaba, Noemi
- ItemRational design of protamine nanocapsules as antigen delivery carriers(2017) González Aramundiz, José Vicente; Presas, Elena; Dalmau Mena, Inmaculada; Martínez Pulgarín, Susana; Alonso, Covadonga; Escribano, José M.; Alonso, María J.; Csaba, Noemi Stefánia
- ItemSafety and immunogenicity evaluation of recombinant BCG vaccine against respiratory syncytial virus in a randomized, double-blind, placebo-controlled phase I clinical trial(2020) Abarca Villaseca, Katia; Rey Jurado, Emma; Muñoz Durango, Natalia; Soto Ramírez, Jorge Andrés; Gálvez Arriagada, Nicolás Marcelo Salvador; Borzutzky Schachter, Arturo; Cerda, Jaime; Villarroel del Pino, Luis A.; González Muñoz, Pablo Alberto; González Aramundiz, José Vicente; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes; Valdés-Ferrada, J.; Iturriaga, C.; Urzúa, M.; Madrid, V.; Bueno Ramírez, Susan; Vázquez, Y.
- ItemVersatile protamine nanocapsules to restore miR-145 levels and interfere tumor growth in colorectal cancer cells(2019) Reimondez Troitino, S.; González Aramundiz, José Vicente; Ruiz Banobre, J.; López López, R.; Alonso, M. J.; Csaba, N.; De la Fuente, M.