Browsing by Author "Godoy, J."

Now showing 1 - 11 of 11
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    Are microRNAs the Molecular Link Between Metabolic Syndrome and Alzheimer's Disease?
    (2016) Codocedo, J.; Rios, J; Godoy, J.; Inestrosa Cantín, Nibaldo
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    Características e impacto de la sedación, la analgesia y el bloqueo neuromuscular en los pacientes críticos que recibieron ventilación mecánica prolongada
    (2009) Tobar, E.; Bugedo Tarraza, Guillermo; Andresen Hernández, Max; Aguirre, M.; Lira, M. T.; Godoy, J.; González, H.; Hernández, A.; Tomicic, V.; Castro, J.; Jara, J.; Ugarte, H.
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    Características y evolución de los pacientes que ingresan a una unidad de cuidados intensivos de un hospital público
    (2016) Ruiz, C.; Díaz, Marco A.; Zapata, J.; Bravo Morales, Sebastián; Panay, S.; Escobar, C.; Godoy, J.; Andresen Hernández, Max; Castro López, Ricardo
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    Chilean experience in liver transplantation for acute liver failure in children
    (2010) Uribe, M.; Alba, A.; Hunter, B.; Valverde, C.; Godoy, J.; Ferrario, M.; Buckel, E.; Cavallieri, S.; Rebolledo Acevedo, Rolando Arturo; Herzog, C.; Calabrán, L.; Flores, L.; Soto, P.
    Background: Acute liver failure (ALF) in children is a life-threatening condition, associated with high mortality, and in almost one third of the cases, with no other therapeutic option than orthotopic liver transplant (OLT). The aim of this study was to present our experience with OLT for ALF in pediatric patients in Chile. Patients fulfilling the criteria for ALF who were transplanted in our centers were prospectively included in an excel Microsoft database. We analyzed demographics, etiology, surgical techniques, complications, and long-term results. Patients and Methods: Between 1994 and 2009, we transplanted 52 pediatric patients with ALF. The most frequent known etiology was acute hepatitis A in 9 cases (18%), but in 26 cases (50%) it was impossible to determine the etiology. Thirty- one patients were males (63%). The overall mean age was 7.5 years and the mean weight, 28.1 kg. Thirty-five (67%) received a cadaveric graft. Among them in 18 cases (34%) the liver had to be reduced but 17 (33%) received whole livers. There were 17 (33%) recipients of living-related livers. Twenty-two patients needed reoperation, including 13 due to surgical complications (59%) and 9 (41%) as planned interventions. Ten patients were retransplanted. Results: Actuarial survival of patients at 1 year was 80% and at 5 and 10 years, 72%. Graft survival at 1 year was 79%, at 5 years 69%, and at 10 years 50%. Conclusion: We have reported a series of pediatric liver transplant patients due to ALF whose results were comparable to other reported series. Living donor transplantation for ALF should be considered and offers a low morbidity rate without mortality.
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    Estado epiléptico refractario en niños
    (2013) Mesa, T.; Cardoso, I.; Acevedo, K.; Hernández, Marta; Santín Amo, José María; Moya, P.; Godoy, J.; Castillo, Andrés; Soto, P.
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    Liver transplantation in children weighing less than 10 kg.: chilean experience
    (2013) Uribe, M.; Alba, A.; Hunter, B.; González, G.; Godoy, J.; Ferrario, M.; Buckel, E.; Cavallieri, S.; Heine, C.; Rebolledo Acevedo, Rolando Arturo; Auad, H.; Acuña, C.
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    Metformin protects from oxaliplatin induced peripheral neuropathy in rats
    (2020) Martínez, N. W.; Sánchez, A.; Díaz, P.; Broekhuizen, R.; Godoy, J.; Mondaca, S.; Catenaccio, A.; Macanas Pirard, Patricia; Calvo Bascuñan, Margarita; Court G., Felipe; Nervi, B.
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    Niveles de hormonas tiroideas en niños obesos. Thyroid function in obese children
    (2014) Sanchez, T.; Godoy, J.; García Bruce, Hernán; Barja Y., Salesa
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    Pediatric liver transplantation experience and outcome in Chile
    (2013) Acuña, C.; Zuleta, R.; Dalmazzo, R.; Valverde, C.; Uribe, M.; Alba, A.; Buckel, E.; Hunter, B.; González, G.; Godoy, J.; Ferrario, M.; Cavallieri, S.; Campos, M.; Pizarro, F.; Wash, A.; Ferrón, S.; Díaz, V.; Macho, L.; Herzog, C.; Calabrán, L.; Flores, L.; Soto, P.; Heine, C.; Rebolledo Acevedo, Rolando Arturo; Auad, H.
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    The implementation of an analgesia-based sedation protocol reduced deep sedation and proved to be safe and feasible in patients on mechanical ventilation
    (2013) Bugedo Tarraza, Guillermo; Tobar, E.; Aguirre, M.; Gonzalez, H.; Godoy, J.; Lira, M. T.; Lora, P.; Encalada, E.; Hernandez, A.; Tomicic, V.; Castro, J.; Jara, J.; Andresen Hernández, Max; Ugarte, H.
    INTRODUCTION: Deep sedation in critically ill patients is associated with a longer duration of mechanical ventilation and a prolonged length of stay in the intensive care unit. Several protocols have been used to improve these outcomes. We implement and evaluate an analgesia-based, goal-directed, nurse-driven sedation protocol used to treat critically ill patients who receive mechanical ventilation. METHODS: We performed a prospective, two-phase (before-after), non-randomized multicenter study that involved 13 intensive care units in Chile. After an observational phase (observational group, n=155), we designed, implemented and evaluated an analgesia-based, goal-directed, nurse-driven sedation protocol (intervention group, n=132) to treat patients who required mechanical ventilation for more than 48 hours. The primary outcome was to achieve ventilator-free days by day 28. RESULTS: The proportion of patients in deep sedation or in a coma decreased from 55.2% to 44.0% in the interventional group. Agitation did not change between the periods and remained approximately 7%. Ventilator-free days to day 28, length of stay in the intensive care unit and mortality were similar in both groups. At one year, post-traumatic stress disorder symptoms in survivors were similar in both groups. CONCLUSIONS: We designed and implemented an analgesia-based, goal-directed, nurse-driven sedation protocol in Chile. Although there was no improvement in major outcomes, we observed that the present protocol was safe and feasible and that it resulted in decreased periods of deep sedation without increasing agitation.INTRODUCTION: Deep sedation in critically ill patients is associated with a longer duration of mechanical ventilation and a prolonged length of stay in the intensive care unit. Several protocols have been used to improve these outcomes. We implement and evaluate an analgesia-based, goal-directed, nurse-driven sedation protocol used to treat critically ill patients who receive mechanical ventilation. METHODS: We performed a prospective, two-phase (before-after), non-randomized multicenter study that involved 13 intensive care units in Chile. After an observational phase (observational group, n=155), we designed, implemented and evaluated an analgesia-based, goal-directed, nurse-driven sedation protocol (intervention group, n=132) to treat patients who required mechanical ventilation for more than 48 hours. The primary outcome was to achieve ventilator-free days by day 28. RESULTS: The proportion of patients in deep sedation or in a coma decreased from 55.2% to 44.0% in the interventional group. Agitation did not change between the periods and remained approximately 7%. Ventilator-free days to day 28, length of stay in the intensive care unit and mortality were similar in both groups. At one year, post-traumatic stress disorder symptoms in survivors were similar in both groups. CONCLUSIONS: We designed and implemented an analgesia-based, goal-directed, nurse-driven sedation protocol in Chile. Although there was no improvement in major outcomes, we observed that the present protocol was safe and feasible and that it resulted in decreased periods of deep sedation without increasing agitation.