Browsing by Author "Gieger, Christian"
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- ItemAssociation of Novel Genetic Loci With Circulating Fibrinogen Levels A Genome-Wide Association Study in 6 Population-Based Cohorts(LIPPINCOTT WILLIAMS & WILKINS, 2009) Dehghan, Abbas; Yang, Qiong; Peters, Annette; Basu, Saonli; Bis, Joshua C.; Rudnicka, Alicja R.; Kavousi, Maryam; Chen, Ming Huei; Baumert, Jens; Lowe, Gordon D. O.; McKnight, Barbara; Tang, Weihong; de Maat, Moniek; Larson, Martin G.; Eyhermendy, Susana; McArdle, Wendy L.; Lumley, Thomas; Pankow, James S.; Hofman, Albert; Massaro, Joseph M.; Rivadeneira, Fernando; Kolz, Melanie; Taylor, Kent D.; van Duijn, Cornelia M.; Kathiresan, Sekar; Illig, Thomas; Aulchenko, Yurii S.; Volcik, Kelly A.; Johnson, Andrew D.; Uitterlinden, Andre G.; Tofler, Geoffrey H.; Gieger, Christian; Psaty, Bruce M.; Couper, David J.; Boerwinkle, Eric; Koenig, Wolfgang; O'Donnell, Christopher J.; Witteman, Jacqueline C.; Strachan, David P.; Smith, Nicholas L.; Folsom, Aaron R.; Wellcome Trust Case Control ConsorBackground: Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels. Methods and Results: We conducted a genome-wide association analysis on 6 population-based studies, the Rotterdam Study, the Framingham Heart Study, the Cardiovascular Health Study, the Atherosclerosis Risk in Communities Study, the Monitoring of Trends and Determinants in Cardiovascular Disease/KORA Augsburg Study, and the British 1958 Birth Cohort Study, including 22 096 participants of European ancestry. Four loci were marked by 1 or more single-nucleotide polymorphisms that demonstrated genome-wide significance (P<5.0×10-8). These included a single-nucleotide polymorphism located in the fibrinogen β chain (FGB) gene and 3 single-nucleotide polymorphisms representing newly identified loci. The high-signal single-nucleotide polymorphisms were rs1800789 in exon 7 of FGB (P=1.8×10-30), rs2522056 downstream from the interferon regulatory factor 1 (IRF1) gene (P=1.3×10-15), rs511154 within intron 1 of the propionyl coenzyme A carboxylase (PCCB) gene (P=5.9×10-10), and rs1539019 on the NLR family pyrin domain containing 3 isoforms (NLRP3) gene (P=1.04×10-8). Conclusions: Our findings highlight biological pathways that may be important in regulation of inflammation underlying cardiovascular disease. © 2009 American Heart Association, Inc.
- ItemGenetic variants in novel pathways influence blood pressure and cardiovascular disease risk(NATURE PUBLISHING GROUP, 2011) Ehret, Georg B.; Munroe, Patricia B.; Rice, Kenneth M.; Bochud, Murielle; Johnson, Andrew D.; Chasman, Daniel I.; Smith, Albert V.; Tobin, Martin D.; Verwoert, Germaine C.; Hwang, Shih Jen; Pihur, Vasyl; Vollenweider, Peter; O'Reilly, Paul F.; Amin, Najaf; Bragg Gresham, Jennifer L.; Teumer, Alexander; Glazer, Nicole L.; Launer, Lenore; Zhao, Jing Hua; Aulchenko, Yurii; Heath, Simon; Sober, Siim; Parsa, Afshin; Luan, Jian'an; Arora, Pankaj; Dehghan, Abbas; Zhang, Feng; Lucas, Gavin; Hicks, Andrew A.; Jackson, Anne U.; Peden, John F.; Tanaka, Toshiko; Wild, Sarah H.; Rudan, Igor; Igl, Wilmar; Milaneschi, Yuri; Parker, Alex N.; Fava, Cristiano; Chambers, John C.; Fox, Ervin R.; Kumari, Meena; Go, Min Jin; van der Harst, Pim; Kao, Wen Hong Linda; Sjogren, Marketa; Vinay, D. G.; Alexander, Myriam; Tabara, Yasuharu; Shaw Hawkins, Sue; Whincup, Peter H.; Liu, Yongmei; Shi, Gang; Kuusisto, Johanna; Tayo, Bamidele; Seielstad, Mark; Sim, Xueling; Khanh Dung Hoang Nguyen; Lehtimaki, Terho; Matullo, Giuseppe; Wu, Ying; Gaunt, Tom R.; Onland Moret, N. Charlotte; Cooper, Matthew N.; Platou, Carl G. P.; Org, Elin; Hardy, Rebecca; Dahgam, Santosh; Palmen, Jutta; Vitart, Veronique; Braund, Peter S.; Kuznetsova, Tatiana; Uiterwaal, Cuno S. P. M.; Adeyemo, Adebowale; Palmas, Walter; Campbell, Harry; Ludwig, Barbara; Tomaszewski, Maciej; Tzoulaki, Ioanna; Palmer, Nicholette D.; Aspelund, Thor; Garcia, Melissa; Chang, Yen Pei C.; O'Connell, Jeffrey R.; Steinle, Nanette I.; Grobbee, Diederick E.; Arking, Dan E.; Kardia, Sharon L.; Morrison, Alanna C.; Hernandez, Dena; Najjar, Samer; McArdle, Wendy L.; Hadley, David; Brown, Morris J.; Connell, John M.; Hingorani, Aroon D.; Day, Ian N. M.; Lawlor, Debbie A.; Beilby, John P.; Lawrence, Robert W.; Clarke, Robert; Hopewell, Jemma C.; Ongen, Halit; Dreisbach, Albert W.; Li, Yali; Young, J. Hunter; Bis, Joshua C.; Kahonen, Mika; Viikari, Jorma; Adair, Linda S.; Lee, Nanette R.; Chen, Ming Huei; Olden, Matthias; Pattaro, Cristian; Bolton, Judith A. Hoffman; Koettgen, Anna; Bergmann, Sven; Mooser, Vincent; Chaturvedi, Nish; Frayling, Timothy M.; Islam, Muhammad; Jafar, Tazeen H.; Erdmann, Jeanette; Kulkarni, Smita R.; Bornstein, Stefan R.; Graessler, Juergen; Groop, Leif; Voight, Benjamin F.; Kettunen, Johannes; Howard, Philip; Taylor, Andrew; Guarrera, Simonetta; Ricceri, Fulvio; Emilsson, Valur; Plump, Andrew; Barroso, Ine S.; Khaw, Kay Tee; Weder, Alan B.; Hunt, Steven C.; Sun, Yan V.; Bergman, Richard N.; Collins, Francis S.; Bonnycastle, Lori L.; Scott, Laura J.; Stringham, Heather M.; Peltonen, Leena; Perola, Markus; Vartiainen, Erkki; Brand, Stefan Martin; Staessen, Jan A.; Wang, Thomas J.; Burton, Paul R.; Artigas, Maria Soler; Dong, Yanbin; Snieder, Harold; Wang, Xiaoling; Zhu, Haidong; Lohman, Kurt K.; Rudock, Megan E.; Heckbert, Susan R.; Smith, Nicholas L.; Wiggins, Kerri L.; Doumatey, Ayo; Shriner, Daniel; Veldre, Gudrun; Viigimaa, Margus; Kinra, Sanjay; Prabhakaran, Dorairaj; Tripathy, Vikal; Langefeld, Carl D.; Rosengren, Annika; Thelle, Dag S.; Corsi, Anna Maria; Singleton, Andrew; Forrester, Terrence; Hilton, Gina; McKenzie, Colin A.; Salako, Tunde; Iwai, Naoharu; Kita, Yoshikuni; Ogihara, Toshio; Ohkubo, Takayoshi; Okamura, Tomonori; Ueshima, Hirotsugu; Umemura, Satoshi; Eyheramendy, Susana; Meitinger, Thomas; Wichmann, H. Erich; Cho, Yoon Shin; Kim, Hyung Lae; Lee, Jong Young; Scott, James; Sehmi, Joban S.; Zhang, Weihua; Hedblad, Bo; Nilsson, Peter; Smith, George Davey; Wong, Andrew; Narisu, Narisu; Stancakova, Alena; Raffel, Leslie J.; Yao, Jie; Kathiresan, Sekar; O'Donnell, Christopher J.; Schwartz, Stephen M.; Ikram, M. Arfan; Longstreth, W. T., Jr.; Mosley, Thomas H.; Seshadri, Sudha; Shrine, Nick R. G.; Wain, Louise V.; Morken, Mario A.; Swift, Amy J.; Laitinen, Jaana; Prokopenko, Inga; Zitting, Paavo; Cooper, Jackie A.; Humphries, Steve E.; Danesh, John; Rasheed, Asif; Goel, Anuj; Hamsten, Anders; Watkins, Hugh; Bakker, Stephan J. L.; van Gilst, Wiek H.; Janipalli, Charles S.; Mani, K. Radha; Yajnik, Chittaranjan S.; Hofman, Albert; Mattace Raso, Francesco U. S.; Oostra, Ben A.; Demirkan, Ayse; Isaacs, Aaron; Rivadeneira, Fernando; Lakatta, Edward G.; Orru, Marco; Scuteri, Angelo; Ala Korpela, Mika; Kangas, Antti J.; Lyytikainen, Leo Pekka; Soininen, Pasi; Tukiainen, Taru; Wurtz, Peter; Ong, Rick Twee Hee; Doerr, Marcus; Kroemer, Heyo K.; Voelker, Uwe; Voelzke, Henry; Galan, Pilar; Hercberg, Serge; Lathrop, Mark; Zelenika, Diana; Deloukas, Panos; Mangino, Massimo; Spector, Tim D.; Zhai, Guangju; Meschia, James F.; Nalls, Michael A.; Sharma, Pankaj; Terzic, Janos; Kumar, M. V. Kranthi; Denniff, Matthew; Zukowska Szczechowska, Ewa; Wagenknecht, Lynne E.; Fowkes, F. Gerald R.; Charchar, Fadi J.; Schwarz, Peter E. H.; Hayward, Caroline; Guo, Xiuqing; Rotimi, Charles; Bots, Michiel L.; Brand, Eva; Samani, Nilesh J.; Polasek, Ozren; Talmud, Philippa J.; Nyberg, Fredrik; Kuh, Diana; Laan, Maris; Hveem, Kristian; Palmer, Lyle J.; van der Schouw, Yvonne T.; Casas, Juan P.; Mohlke, Karen L.; Vineis, Paolo; Raitakari, Olli; Ganesh, Santhi K.; Wong, Tien Y.; Tai, E. Shyong; Cooper, Richard S.; Laakso, Markku; Rao, Dabeeru C.; Harris, Tamara B.; Morris, Richard W.; Dominiczak, Anna F.; Kivimaki, Mika; Marmot, Michael G.; Miki, Tetsuro; Saleheen, Danish; Chandak, Giriraj R.; Coresh, Josef; Navis, Gerjan; Salomaa, Veikko; Han, Bok Ghee; Zhu, Xiaofeng; Kooner, Jaspal S.; Melander, Olle; Ridker, Paul M.; Bandinelli, Stefania; Gyllensten, Ulf B.; Wright, Alan F.; Wilson, James F.; Ferrucci, Luigi; Farrall, Martin; Tuomilehto, Jaakko; Pramstaller, Peter P.; Elosua, Roberto; Soranzo, Nicole; Sijbrands, Eric J. G.; Altshuler, David; Loos, Ruth J. F.; Shuldiner, Alan R.; Gieger, Christian; Meneton, Pierre; Uitterlinden, Andre G.; Wareham, Nicholas J.; Gudnason, Vilmundur; Rotter, Jerome I.; Rettig, Rainer; Uda, Manuela; Strachan, David P.; Witteman, Jacqueline C. M.; Hartikainen, Anna Liisa; Beckmann, Jacques S.; Boerwinkle, Eric; Vasan, Ramachandran S.; Boehnke, Michael; Larson, Martin G.; Jarvelin, Marjo Riitta; Psaty, Bruce M.; Abecasis, Goncalo R.; Chakravarti, Aravinda; Elliott, Paul; van Duijn, Cornelia M.; Newton Cheh, Christopher; Levy, Daniel; Caulfield, Mark J.; Johnson, Toby; Int Consortium Blood Pressure Geno; CARDIoGRAM Consortium; CKDGen Consortium; KidneyGen Consortium; EchoGen Consortium; CHARGE HF ConsortiumBlood pressure is a heritable trait(1) influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (>= 140 mm Hg systolic blood pressure or >= 90 mm Hg diastolic blood pressure)(2). Even small increments in blood pressure are associated with an increased risk of cardiovascular events(3). This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.
- ItemGenome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations(OXFORD UNIV PRESS, 2009) Org, Elin; Eyheramendy, Susana; Juhanson, Peeter; Gieger, Christian; Lichtner, Peter; Klopp, Norman; Veldre, Gudrun; Doering, Angela; Viigimaa, Margus; Sober, Siim; Tomberg, Kaert; Eckstein, Gertrud; Kelgo, Piret; Rebane, Tiina; Shaw Hawkins, Sue; Howard, Philip; Onipinla, Abiodun; Dobson, Richard J.; Newhouse, Stephen J.; Brown, Morris; Dominiczak, Anna; Connell, John; Samani, Nilesh; Farrall, Martin; Caulfield, Mark J.; Munroe, Patricia B.; Illig, Thomas; Wichmann, H. Erich; Meitinger, Thomas; Laan, Maris; KORA; BRIGHTHypertension is a complex disease that affects a large proportion of adult population. Although approximately half of the inter-individual variance in blood pressure (BP) level is heritable, identification of genes responsible for its regulation has remained challenging. Genome-wide association study (GWAS) is a novel approach to search for genetic variants contributing to complex diseases. We conducted GWAS for three BP traits [systolic and diastolic blood pressure (SBP and DBP); hypertension (HYP)] in the Kooperative Gesundheitsforschung in der Region Augsburg (KORA) S3 cohort (n = 1644) recruited from general population in Southern Germany. GWAS with 395 912 single nucleotide polymorphisms (SNPs) identified an association between BP traits and a common variant rs11646213 (T/A) upstream of the CDH13 gene at 16q23.3. The initial associations with HYP and DBP were confirmed in two other European population-based cohorts: KORA S4 (Germans) and HYPEST (Estonians). The associations between rs11646213 and three BP traits were replicated in combined analyses (dominant model: DBP, P = 5.55 x 10(-5), effect -1.40 mmHg; SBP, P = 0.007, effect -1.56 mmHg; HYP, P = 5.30 x 10(-8), OR = 0.67). Carriers of the minor allele A had a decreased risk of hypertension. A non-significant trend for association was also detected with severe family based hypertension in the BRIGHT sample (British). The novel susceptibility locus, CDH13, encodes for an adhesion glycoprotein T-cadherin, a regulator of vascular wall remodeling and angiogenesis. Its function is compatible with the BP biology and may improve the understanding of the pathogenesis of hypertension.
- ItemWorldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants(ELSEVIER SCIENCE INC, 2021) Zhou, Bin; Carrillo Larco, Rodrigo M.; Danaei, Goodarz; Riley, Leanne M.; Paciorek, Christopher J.; Stevens, Gretchen A.; Gregg, Edward W.; Bennett, James E.; Solomon, Bethlehem; Singleton, Rosie K.; Sophiea, Marisa K.; Iurilli, Maria L. C.; Lhoste, Victor P. F.; Cowan, Melanie J.; Savin, Stefan; Woodward, Mark; Balanova, Yulia; Cifkova, Renata; Damasceno, Albertino; Elliott, Paul; Farzadfar, Farshad; He, Jiang; Ikeda, Nayu; Kengne, Andre P.; Khang, Young Ho; Kim, Hyeon Chang; Laxmaiah, Avula; Lin, Hsien Ho; Margozzini Maira, Paula; Miranda, J. Jaime; Neuhauser, Hannelore; Sundstrom, Johan; Varghese, Cherian; Widyahening, Indah S.; Zdrojewski, Tomasz; Ezzati, Majid; Abarca Gomez, Leandra; Abdeen, Ziad A.; Rahim, Hanan F. Abdul; Abu Rmeileh, Niveen M.; Acosta Cazares, Benjamin; Adams, Robert J.; Aekplakorn, Wichai; Afsana, Kaosar; Afzal, Shoaib; Agdeppa, Imelda A.; Aghazadeh Attari, Javad; Aguilar Salinas, Carlos A.; Agyemang, Charles; Ahmad, Noor Ani; Ahmadi, Ali; Ahmadi, Naser; Ahmadi, Nastaran; Ahmadizar, Fariba; Ahmed, Soheir H.; Ahrens, Wolfgang; Ajlouni, Kamel; Al Raddadi, Rajaa; Alarouj, Monira; AlBuhairan, Fadia; AlDhukair, Shahla; Ali, Mohamed M.; Alkandari, Abdullah; Alkerwi, Ala'a; Allin, Kristine; Aly, Eman; Amarapurkar, Deepak N.; Amougou, Norbert; Amouyel, Philippe; Andersen, Lars Bo; Anderssen, Sigmund A.; Anjana, Ranjit Mohan; Ansari Moghaddam, Alireza; Ansong, Daniel; Aounallah Skhiri, Hajer; Araujo, Joana; Ariansen, Inger; Aris, Tahir; Arku, Raphael E.; Arlappa, Nimmathota; Aryal, Krishna K.; Aspelund, Thor; Assah, Felix K.; Assuncao, Maria Cecilia F.; Auvinen, Juha; Avdicova, Maria; Azevedo, Ana; Azimi Nezhad, Mohsen; Azizi, Fereidoun; Azmin, Mehrdad; Babu, Bontha V.; Bahijri, Suhad; Balakrishna, Nagalla; Balanova, Yulia; Bamoshmoosh, Mohamed; Banach, Maciej; Banadinovic, Maja; Bandosz, Piotr; Banegas, Jose R.; Baran, Joanna; Barbagallo, Carlo M.; Barcelo, Alberto; Barkat, Amina; Barreto, Marta; Barros, Aluisio J. D.; Gomes Barros, Mauro Virgilio; Bartosiewicz, Anna; Basit, Abdul; Bastos, Joao Luiz D.; Bata, Iqbal; Batieha, Anwar M.; Batyrbek, Assembekov; Baur, Louise A.; Beaglehole, Robert; Belavendra, Antonisamy; Ben Romdhane, Habiba; Benet, Mikhail; Bennett, James E.; Benson, Lowell S.; Berkinbayev, Salim; Bernabe Ortiz, Antonio; Bettiol, Heloisa; Bezerra, Jorge; Bhagyalaxmi, Aroor; Bhargava, Santosh K.; Bia, Daniel; Biasch, Katia; Lele, Elysee Claude Bika; Bikbov, Mukharram M.; Bista, Bihungum; Bjerregaard, Peter; Bjertness, Espen; Bjertness, Marius B.; Bjorkelund, Cecilia; Bloch, Katia V.; Blokstra, Anneke; Bo, Simona; Bobak, Martin; Boeing, Heiner; Boggia, Jose G.; Boissonnet, Carlos P.; Bojesen, Stig E.; Bongard, Vanina; Bonilla Vargas, Alice; Bopp, Matthias; Borghs, Herman; Bovet, Pascal; Boyer, Christopher B.; Braeckman, Lutgart; Brajkovich, Imperia; Branca, Francesco; Breckenkamp, Juergen; Brenner, Hermann; Brewster, Lizzy M.; Briceno, Yajaira; Brito, Miguel; Bruno, Graziella; Bueno de Mesquita, H. Bas; Bueno, Gloria; Bugge, Anna; Burns, Con; Bursztyn, Michael; Cabrera de Leon, Antonio; Cacciottolo, Joseph; Cameron, Christine; Can, Gunay; Candido, Ana Paula C.; Capanzana, Mario V.; Capkova, Nadezda; Capuano, Eduardo; Capuano, Vincenzo; Cardoso, Viviane C.; Carlsson, Axel C.; Carvalho, Joana; Casanueva, Felipe F.; Censi, Laura; Cervantes Loaiza, Marvin; Chadjigeorgiou, Charalambos A.; Chamukuttan, Snehalatha; Chan, Angelique W.; Chan, Queenie; Chaturvedi, Himanshu K.; Chaturvedi, Nish; Chee, Miao Li; Chen, Chien Jen; Chen, Fangfang; Chen, Huashuai; Chen, Shuohua; Chen, Zhengming; Cheng, Ching Yu; Cheraghian, Bahman; Dekkaki, Imane Cherkaoui; Chetrit, Angela; Chien, Kuo Liong; Chiolero, Arnaud; Chiou, Shu Ti; Chirita Emandi, Adela; Chirlaque, Maria Dolores; Cho, Belong; Christensen, Kaare; Christofaro, Diego G.; Chudek, Jerzy; Cifkova, Renata; Cinteza, Eliza; Claessens, Frank; Clarke, Janine; Clays, Els; Cohen, Emmanuel; Concin, Hans; Cooper, Cyrus; Coppinger, Tara C.; Costanzo, Simona; Cottel, Dominique; Cowell, Chris; Craig, Cora L.; Crampin, Amelia C.; Crujeiras, Ana B.; Cruz, Juan J.; Csilla, Semanova; Cui, Liufu; Cureau, Felipe V.; Cuschieri, Sarah; D'Arrigo, Graziella; d'Orsi, Eleonora; Dallongeville, Jean; Damasceno, Albertino; Danaei, Goodarz; Dankner, Rachel; Dantoft, Thomas M.; Dauchet, Luc; Davletov, Kairat; De Backer, Guy; De Bacquer, Dirk; De Curtis, Amalia; de Gaetano, Giovanni; De Henauw, Stefaan; de Oliveira, Paula Duarte; De Ridder, David; De Smedt, Delphine; Deepa, Mohan; Deev, Alexander D.; DeGennaro, Vincent Jr; Delisle, Helene; Demarest, Stefaan; Dennison, Elaine; Deschamps, Valerie; Dhimal, Meghnath; Di Castelnuovo, Augusto F.; Dias da Costa, Juvenal Soares; Diaz, Alejandro; Dickerson, Ty T.; Dika, Zivka; Djalalinia, Shirin; Do, Ha T. P.; Dobson, Annette J.; Donfrancesco, Chiara; Donoso, Silvana P.; Doering, Angela; Dorobantu, Maria; Doerr, Marcus; Doua, Kouamelan; Dragano, Nico; Drygas, Wojciech; Duante, Charmaine A.; Duboz, Priscilla; Duda, Rosemary B.; Dulskiene, Virginija; Dushpanova, Anar; Dzakula, Aleksandar; Dzerve, Vilnis; Dziankowska Zaborszczyk, Elzbieta; Eddie, Ricky; Eftekhar, Ebrahim; Eggertsen, Robert; Eghtesad, Sareh; Eiben, Gabriele; Ekelund, Ulf; El Khateeb, Mohammad; El Ati, Jalila; Eldemire Shearer, Denise; Eliasen, Marie; Elliott, Paul; Elosua, Roberto; Erasmus, Rajiv T.; Erbel, Raimund; Erem, Cihangir; Eriksen, Louise; Eriksson, Johan G.; Escobedo de la Pena, Jorge; Eslami, Saeid; Esmaeili, Ali; Evans, Alun; Faeh, David; Fakhretdinova, Albina A.; Fall, Caroline H.; Faramarzi, Elnaz; Farjam, Mojtaba; Farzadfar, Farshad; Fattahi, Mohammad Reza; Fawwad, Asher; Felix Redondo, Francisco J.; Felix, Stephan B.; Ferguson, Trevor S.; Fernandes, Romulo A.; Fernandez Berges, Daniel; Ferrante, Daniel; Ferrao, Thomas; Ferrari, Marika; Ferrario, Marco M.; Ferreccio, Catterina; Ferreira, Haroldo S.; Ferrer, Eldridge; Ferrieres, Jean; Figueiro, Thamara Hubler; Fink, Gunther; Fischer, Krista; Foo, Leng Huat; Forsner, Maria; Fouad, Heba M.; Francis, Damian K.; Franco, Maria do Carmo; Frikke Schmidt, Ruth; Frontera, Guillermo; Fuchs, Flavio D.; Fuchs, Sandra C.; Fujita, Yuki; Fumihiko, Matsuda; Furdela, Viktoriya; Furer, Ariel; Furusawa, Takuro; Gaciong, Zbigniew; Galbarczyk, Andrzej; Galenkamp, Henrike; Galvano, Fabio; Gao, Jingli; Gao, Pei; Garcia de la Hera, Manoli; Garcia, Pablo; Gareta, Dickman; Garnett, Sarah P.; Gaspoz, Jean Michel; Gasull, Magda; Gazzinelli, Andrea; Gehring, Ulrike; Geleijnse, Johanna M.; George, Ronnie; Ghanbari, Ali; Ghasemi, Erfan; Gheorghe Fronea, Oana Florentina; Ghimire, Anup; Gialluisi, Alessandro; Giampaoli, Simona; Gieger, Christian; Gill, Tiffany K.; Giovannelli, Jonathan; Gironella, Glen; Giwercman, Aleksander; Gkiouras, Konstantinos; Goldberg, Marcel; Goldsmith, Rebecca A.; Gomez, Luis F.; Gomula, Aleksandra; Cordeiro da Silva, Bruna Goncalves; Goncalves, Helen; Goncalves, Mauer; Gonzalez Chica, David A.; Gonzalez Gross, Marcela; Gonzalez Rivas, Juan P.; Gonzalez Villalpando, Clicerio; Gonzalez Villalpando, Maria Elena; Gonzalez, Angel R.; Bonet Gorbea, Mariano; Gottrand, Frederic; Graff Iversen, Sidsel; Grafnetter, Dusan; Grajda, Aneta; Grammatikopoulou, Maria G.; Gregor, Ronald D.; Grodzicki, Tomasz; Grosso, Giuseppe; Gruden, Gabriella; Gu, Dongfeng; Guan, Ong Peng; Gudmundsson, Elias F.; Gudnason, Vilmundur; Guerrero, Ramiro; Guessous, Idris; Guimaraes, Andre L.; Gulliford, Martin C.; Gunnlaugsdottir, Johanna; Gunter, Marc J.; Gupta, Prakash C.; Gupta, Rajeev; Gureje, Oye; Gurzkowska, Beata; Gutierrez, Laura; Gutzwiller, Felix; Ha, Seongjun; Hadaegh, Farzad; Haghshenas, Rosa; Hakimi, Hamid; Halkjaer, Jytte; Hambleton, Ian R.; Hamzeh, Behrooz; Hange, Dominique; Hanif, Abu A. M.; Hantunen, Sari; Hao, Jie; Hardman, Carla Meneses; Kumar, Rachakulla Hari; Hashemi Shahri, Seyed Mohammad; Hata, Jun; Haugsgjerd, Teresa; Hayes, Alison J.; He, Jiang; He, Yuna; Heier, Margit; Hendriks, Marleen Elisabeth; Henrique, Rafael dos Santos; Henriques, Ana; Cadena, Leticia Hernandez; Herrala, Sauli; Heshmat, Ramin; Hill, Allan G.; Ho, Sai Yin; Ho, Suzanne C.; Hobbs, Michael; Holdsworth, Michelle; Homayounfar, Reza; Dinc, Gonul Horasan; Horimoto, Andrea R. V. R.; Hormiga, Claudia M.; Horta, Bernardo L.; Houti, Leila; Howitt, Christina; Htay, Thein Thein; Htet, Aung Soe; Htike, Maung Maung Than; Hu, Yonghua; Huerta, Jose Maria; Huhtaniemi, Ilpo Tapani; Huiart, Laetitia; Huisman, Martijn; Husseini, Abdullatif S.; Huybrechts, Inge; Hwalla, Nahla; Iacoviello, Licia; Iannone, Anna G.; Ibrahim, Mohsen M.; Wong, Norazizah Ibrahim; Ikeda, Nayu; Ikram, M. Arfan; Iotova, Violeta; Irazola, Vilma E.; Ishida, Takafumi; Isiguzo, Godsent C.; Islam, Muhammad; Islam, Sheikh Mohammed Shariful; Iwasaki, Masanori; Jackson, Rod T.; Jacobs, Jeremy M.; Jaddou, Hashem Y.; Jafar, Tazeen; James, Kenneth; Jamrozik, Konrad; Janszky, Imre; Janus, Edward; Jarvelin, Marjo Riitta; Jasienska, Grazyna; Jelakovic, Ana; Jelakovic, Bojan; Jennings, Garry; Jha, Anjani Kumar; Jiang, Chao Qiang; Jimenez, Ramon O.; Joeckel, Karl Heinz; Joffres, Michel; Johansson, Mattias; Jokelainen, Jari J.; Jonas, Jost B.; Jorgensen, Torben; Joshi, Pradeep; Joukar, Farahnaz; Jozwiak, Jacek; Juolevi, Anne; Jurak, Gregor; Juresa, Vesna; Kaaks, Rudolf; Kafatos, Anthony; Kajantie, Eero O.; Kalmatayeva, Zhanna; Kalpourtzi, Natasa; Kalter Leibovici, Ofra; Kampmann, Freja B.; Kannan, Srinivasan; Karaglani, Eva; Karhus, Line L.; Karki, Khem B.; Katibeh, Marzieh; Katz, Joanne; Kauhanen, Jussi; Kaur, Prabhdeep; Kavousi, Maryam; Kazakbaeva, Gyulli M.; Keil, Ulrich; Boker, Lital Keinan; Keinanen Kiukaanniemi, Sirkka; Kelishadi, Roya; Kemper, Han C. G.; Kengne, Andre P.; Keramati, Maryam; Kerimkulova, Alina; Kersting, Mathilde; Key, Timothy; Khader, Yousef Saleh; Khalili, Davood; Khang, Young Ho; Khaw, Kay Tee; Kheiri, Bahareh; Kheradmand, Motahareh; Khosravi, Alireza; Kiechl Kohlendorfer, Ursula; Kiechl, Stefan; Killewo, Japhet; Kim, Dong Wook; Kim, Hyeon Chang; Kim, Jeongseon; Klakk, Heidi; Klimek, Magdalena; Klumbiene, Jurate; Knoflach, Michael; Kolle, Elin; Kolsteren, Patrick; Kontto, Jukka P.; Korpelainen, Raija; Korrovits, Paul; Kos, Jelena; Koskinen, Seppo; Kouda, Katsuyasu; Kowlessur, Sudhir; Koziel, Slawomir; Kratenova, Jana; Kriaucioniene, Vilma; Kristensen, Peter Lund; Krokstad, Steiner; Kromhout, Daan; Kruger, Herculina S.; Kubinova, Ruzena; Kuciene, Renata; Kujala, Urho M.; Kulaga, Zbigniew; Kumar, R. Krishna; Kurjata, Pawel; Kusuma, Yadlapalli S.; Kutsenko, Vladimir; Kuulasmaa, Kari; Kyobutungi, Catherine; Laatikainen, Tiina; Lachat, Carl; Laid, Youcef; Lam, Tai Hing; Landrove, Orlando; Lanska, Vera; Lappas, Georg; Larijani, Bagher; Latt, Tint Swe; Laxmaiah, Avula; Le Coroller, Gwenaelle; Khanh Le Nguyen Bao; Le, Tuyen D.; Lee, Jeannette; Lee, Jeonghee; Lehmann, Nils; Lehtimaki, Terho; Lemogoum, Daniel; Levitt, Naomi S.; Li, Yanping; Lilly, Christa L.; Lim, Wei Yen; Lima Costa, M. Fernanda; Lin, Hsien Ho; Lin, Xu; Lin, Yi Ting; Lind, Lars; Lingam, Vijaya; Linneberg, Allan; Lissner, Lauren; Litwin, Mieczyslaw; Lo, Wei Cheng; Loit, Helle Mai; Lopez Garcia, Esther; Lopez, Tania; Lotufo, Paulo A.; Lozano, Jose Eugenio; Lovrencic, Iva Lukacevic; Lukrafka, Janice L.; Luksiene, Dalia; Lundqvist, Annamari; Lundqvist, Robert; Lunet, Nuno; Lustigova, Michala; Luszczki, Edyta; Ma, Guansheng; Ma, Jun; Machado Coelho, George L. L.; Machado Rodrigues, Aristides M.; Macia, Enguerran; Macieira, Luisa M.; Madar, Ahmed A.; Maggi, Stefania; Magliano, Dianna J.; Magriplis, Emmanuella; Mahasampath, Gowri; Maire, Bernard; Majer, Marjeta; Makdisse, Marcia; Malekzadeh, Fatemeh; Malekzadeh, Reza; Malhotra, Rahul; Mallikharjuna, Kodavanti; Malyutina, Sofia K.; Maniego, Lynell V.; Manios, Yannis; Mann, Jim I.; Mansour Ghanaei, Fariborz; Manzato, Enzo; Marcil, Anie; Margozzini, Paula; Marild, Staffan B.; Glavic, Mihalea Marinovic; Marques Vidal, Pedro; Marques, Larissa Pruner; Marrugat, Jaume; Martorell, Reynaldo; Mascarenhas, Luis P.; Matasin, Marija; Mathiesen, Ellisiv B.; Mathur, Prashant; Matijasevich, Alicia; Matlosz, Piotr; Matsha, Tandi E.; Mavrogianni, Christina; Mbanya, Jean Claude N.; Mc Donald Posso, Anselmo J.; McFarlane, Shelly R.; McGarvey, Stephen T.; McLachlan, Stela; McLean, Rachael M.; McLean, Scott B.; McNulty, Breige A.; Benchekor, Sounnia Mediene; Medzioniene, Jurate; Mehdipour, Parinaz; Mehlig, Kirsten; Mehrparvar, Amir Houshang; Meirhaeghe, Aline; Meisinger, Christa; Mendoza Montano, Carlos; Menezes, Ana Maria B.; Menon, Geetha R.; Mereke, Alibek; Meshram, Indrapal I.; Metspalu, Andres; Meyer, Haakon E.; Mi, Jie; Michels, Nathalie; Mikkel, Kairit; Milkowska, Karolina; Miller, Jody C.; Minderico, Claudia S.; Mini, G. K.; Miranda, J. Jaime; Mirjalili, Mohammad Reza; Mirrakhimov, Erkin; Misigoj Durakovic, Marjeta; Modesti, Pietro A.; Moghaddam, Sahar Saeedi; Mohajer, Bahram; Mohamed, Mostafa K.; Mohamed, Shukri F.; Mohammad, Kazem; Mohammadi, Mohammad Reza; Mohammadi, Zahra; Mohammadifard, Noushin; Mohammadpourhodki, Reza; Mohan, Viswanathan; Mohanna, Salim; Yusoff, Muhammad Fadhli Mohd; Mohebbi, Iraj; Mohebi, Farnam; Moitry, Marie; Mollehave, Line T.; Molnar, Denes; Momenan, Amirabbas; Mondo, Charles K.; Monterrubio Flores, Eric; Monyeki, Kotsedi Daniel K.; Moon, Jin Soo; Moosazadeh, Mahmood; Moreira, Leila B.; Morejon, Alain; Moreno, Luis A.; Morgan, Karen; Moschonis, George; Mossakowska, Malgorzata; Mostafa, Aya; Mostafavi, Seyed Ali; Mota, Jorge; Motlagh, Mohammad Esmaeel; Motta, Jorge; Andre Moura dos Santos, Marcos; Mridha, Malay K.; Msyamboza, Kelias P.; Mu, Thet Thet; Muhihi, Alfa J.; Muiesan, Maria L.; Muller Nurasyid, Martina; Murphy, Neil; Mursu, Jaakko; Musa, Kamarul Imran; Milanovic, Sanja Music; Musil, Vera; Mustafa, Norlaila; Nabipour, Iraj; Naderimagham, Shohreh; Nagel, Gabriele; Naidu, Balkish M.; Najafi, Farid; Nakamura, Harunobu; Namesna, Jana; Nang, Ei Ei K.; Nangia, Vinay B.; Narake, Sameer; Ndiaye, Ndeye Coumba; Neal, William A.; Nejatizadeh, Azim; Nenko, Ilona; Neovius, Martin; Neuhauser, Hannelore K.; Nguyen, Chung T.; Nguyen, Nguyen D.; Nguyen, Quang V.; Quang Ngoc Nguyen; Nieto Martinez, Ramfis E.; Niiranen, Teemu J.; Nikitin, Yury P.; Ninomiya, Toshiharu; Nishtar, Sania; Njelekela, Marina A.; Noale, Marianna; Noboa, Oscar A.; Noorbala, Ahmad Ali; Norat, Teresa; Nordendahl, Maria; Nordestgaard, Borge G.; Noto, Davide; Nowak Szczepanska, Natalia; Al Nsour, Mohannad; Nunes, Baltazar; O'Neill, Terence W.; O'Reilly, Dermot; Ochimana, Caleb; Oda, Eiji; Odili, Augustine N.; Oh, Kyungwon; Ohara, Kumiko; Ohtsuka, Ryutaro; Olie, Valerie; Olinto, Maria Teresa A.; Oliveira, Isabel O.; Omar, Mohd Azahadi; Onat, Altan; Ong, Sok King; Ono, Lariane M.; Ordunez, Pedro; Ornelas, Rui; Ortiz, Pedro J.; Osmond, Clive; Ostojic, Sergej M.; Ostovar, Afshin; Otero, Johanna A.; Overvad, Kim; Owusu Dabo, Ellis; Paccaud, Fred Michel; Padez, Cristina; Pahomova, Elena; de Paiva, Karina Mary; Pajak, Andrzej; Palli, Domenico; Palmieri, Luigi; Pan, Wen Harn; Panda Jonas, Songhomitra; Panza, Francesco; Paoli, Mariela; Papandreou, Dimitrios; Park, Soon Woo; Park, Suyeon; Parnell, Winsome R.; Parsaeian, Mahboubeh; Pasquet, Patrick; Patel, Nikhil D.; Pavlyshyn, Halyna; Pecin, Ivan; Pednekar, Mangesh S.; Pedro, Joao M.; Peer, Nasheeta; Peixoto, Sergio Viana; Peltonen, Markku; Pereira, Alexandre C.; Peres, Karen G. D. A.; Peres, Marco A.; Peters, Annette; Petkeviciene, Janina; Peykari, Niloofar; Son Thai Pham; Pichardo, Rafael N.; Pigeot, Iris; Pikhart, Hynek; Pilav, Aida; Pilotto, Lorenza; Pitakaka, Freda; Piwonska, Aleksandra; Pizarro, Andreia N.; Plans Rubio, Pedro; Polasek, Ozren; Porta, Miquel; Poudyal, Anil; Pourfarzi, Farhad; Pourshams, Akram; Poustchi, Hossein; Pradeepa, Rajendra; Price, Alison J.; Price, Jacqueline F.; Providencia, Rui; Puhakka, Soile E.; Puiu, Maria; Punab, Margus; Qasrawi, Radwan F.; Qorbani, Mostafa; Queiroz, Daniel; Tran Quoc Bao; Radic, Ivana; Radisauskas, Ricardas; Rahimikazerooni, Salar; Rahman, Mahfuzar; Raitakari, Olli; Raj, Manu; Rakhimova, Ellina M.; Rao, Sudha Ramachandra; Ramachandran, Ambady; Ramos, Elisabete; Rampal, Lekhraj; Rampal, Sanjay; Rangel Reina, Daniel A.; Rarra, Vayia; Rech, Cassiano Ricardo; Redon, Josep; Reganit, Paul Ferdinand M.; Regecova, Valeria; Revilla, Luis; Rezaianzadeh, Abbas; Ribeiro, Robespierre; Riboli, Elio; Richter, Adrian; Rigo, Fernando; de Wit, Tobias F. Rinke; Ritti Dias, Raphael M.; Robitaille, Cynthia; Rodriguez Artalejo, Fernando; del Cristo Rodriguez Perez, Maria; Rodriguez Villamizar, Laura A.; Roggenbuck, Ulla; Rojas Martinez, Rosalba; Romaguera, Dora; Romeo, Elisabetta L.; Rosengren, Annika; Roy, Joel G. R.; Rubinstein, Adolfo; Ruidavets, Jean Bernard; Sandra Ruiz Betancourt, Blanca; Ruiz Castell, Maria; Rusakova, Iuliia A.; Russo, Paola; Rutkowski, Marcin; Sabanayagam, Charumathi; Sabbaghi, Hamideh; Sachdev, Harshpal S.; Sadjadi, Alireza; Safarpour, Ali Reza; Safi, Sare; Safiri, Saeid; Saidi, Olfa; Sakarya, Sibel; Saki, Nader; Salanave, Benoit; Salazar Martinez, Eduardo; Salmeron, Diego; Salomaa, Veikko; Salonen, Jukka T.; Salvetti, Massimo; Sanchez Abanto, Jose; Sans, Susana; Santos, Diana A.; Santos, Ina S.; Santos, Lelita C.; Santos, Maria Paula; Santos, Rute; Saramies, Jouko L.; Sardinha, Luis B.; Sarganas, Giselle; Sarrafzadegan, Nizal; Sathish, Thirunavukkarasu; Saum, Kai Uwe; Savva, Savvas; Sawada, Norie; Sbaraini, Mariana; Scazufca, Marcia; Schaan, Beatriz D.; Schargrodsky, Herman; Schipf, Sabine; Schmidt, Carsten O.; Schnohr, Peter; Schoettker, Ben; Schramm, Sara; Schultsz, Constance; Schutte, Aletta E.; Sebert, Sylvain; Sein, Aye Aye; Sen, Abhijit; Senbanjo, Idowu O.; Sepanlou, Sadaf G.; Servais, Jennifer; Shalnova, Svetlana A.; Shamah Levy, Teresa; Shamshirgaran, Morteza; Shanthirani, Coimbatore Subramaniam; Sharafkhah, Maryam; Sharma, Sanjib K.; Shaw, Jonathan E.; Shayanrad, Amaneh; Shayesteh, Ali Akbar; Shi, Zumin; Shibuya, Kenji; Shimizu Furusawa, Hana; Shin, Dong Wook; Shirani, Majid; Shiri, Rahman; Shrestha, Namuna; Si Ramlee, Khairil; Siani, Alfonso; Siantar, Rosalynn; Sibai, Abla M.; de Moura Silva, Caroline Ramos; Santos Silva, Diego Augusto; Simon, Mary; Simons, Judith; Simons, Leon A.; Sjostrom, Michael; Slowikowska Hilczer, Jolanta; Slusarczyk, Przemyslaw; Smeeth, Liam; So, Hung Kwan; Soares, Fernanda Cunha; Sobngwi, Eugene; Soderberg, Stefan; Soemantri, Agustinus; Sofat, Reecha; Solfrizzi, Vincenzo; Somi, Mohammad Hossein; Sonestedt, Emily; Song, Yi; Sorensen, Thorkild I. A.; Sorgjerd, Elin P.; Soric, Maroje; Jerome, Charles Sossa; Soumare, Aicha; Sparboe Nilsen, Bente; Sparrenberger, Karen; Staessen, Jan A.; Starc, Gregor; Stavreski, Bill; Steene Johannessen, Jostein; Stehle, Peter; Stein, Aryeh D.; Stergiou, George S.; Stessman, Jochanan; Stieber, Jutta; Stoeckl, Doris; Stocks, Tanja; Stokwiszewski, Jakub; Stronks, Karien; Strufaldi, Maria Wany; Suka, Machi; Sun, Chien An; Sundstrom, Johan; Sung, Yn Tz; Suriyawongpaisal, Paibul; Sy, Rody G.; Syddall, Holly E.; Sylva, Rene Charles; Szklo, Moyses; Tai, E. Shyong; Tammesoo, Mari Liis; Tamosiunas, Abdonas; Tan, Eng Joo; Tang, Xun; Tanser, Frank; Tao, Yong; Tarawneh, Mohammed Rasoul; Tarqui Mamani, Carolina B.; Taylor, Anne; Taylor, Julie; Tebar, William R.; Tell, Grethe S.; Tello, Tania; Tham, Yih Chung; Thankappan, K. R.; Theobald, Holger; Theodoridis, Xenophon; Thijs, Lutgarde; Thinggaard, Mikael; Thomas, Nihal; Thorand, Barbara; Thuesen, Betina H.; Timmermans, Erik J.; Tjandrarini, Dwi H.; Tjonneland, Anne; Toft, Ulla; Tolonen, Hanna K.; Tolstrup, Janne S.; Topbas, Murat; Topor Madry, Roman; Jose Tormo, Maria; Tornaritis, Michael J.; Torrent, Maties; Torres Collado, Laura; Touloumi, Giota; Traissac, Pierre; Triantafyllou, Areti; Trichopoulos, Dimitrios; Trichopoulou, Antonia; Trinh, Oanh T. H.; Trivedi, Atul; Tshepo, Lechaba; Tsugane, Shoichiro; Tuliakova, Azaliia M.; Tulloch Reid, Marshall K.; Tullu, Fikru; Tuomainen, Tomi Pekka; Tuomilehto, Jaakko; Turley, Maria L.; Twig, Gilad; Tynelius, Per; Tzourio, Christophe; Ueda, Peter; Ugel, Eunice; Ulmer, Hanno; Uusitalo, Hannu M. T.; Valdivia, Gonzalo; Valvi, Damaskini; van Dam, Rob M.; van den Born, Bert Jan; Van der Heyden, Johan; van der Schouw, Yvonne T.; Van Herck, Koen; Hoang Van Minh; Van Schoor, Natasja M.; van Valkengoed, Irene G. M.; van Zutphen, Elisabeth M.; Vanderschueren, Dirk; Vanuzzo, Diego; Varbo, Anette; Vasan, Senthil K.; Vega, Tomas; Veidebaum, Toomas; Velasquez Melendez, Gustavo; Veronesi, Giovanni; Verschuren, W. M. Monique; Verstraeten, Roosmarijn; Victora, Cesar G.; Viet, Lucie; Villalpando, Salvador; Vineis, Paolo; Vioque, Jesus; Virtanen, Jyrki K.; Visvikis Siest, Sophie; Viswanathan, Bharathi; Vlasoff, Tiina; Vollenweider, Peter; Voutilainen, Ari; Wade, Alisha N.; Walton, Janette; Wambiya, Elvis O. A.; Bebakar, Wan Mohamad Wan; Mohamud, Wan Nazaimoon Wan; Wanderley Junior, Rildo de Souza; Wang, Ming Dong; Wang, Ningli; Wang, Qian; Wang, Xiangjun; Wang, Ya Xing; Wang, Ying Wei; Wannamethee, S. Goya; Wareham, Nicholas; Wei, Wenbin; Weres, Aneta; Werner, Bo; Whincup, Peter H.; Widhalm, Kurt; Widyahening, Indah S.; Wiecek, Andrzej; Wilks, Rainford J.; Willeit, Johann; Willeit, Peter; Williams, Emmanuel A.; Wilsgaard, Tom; Wojtyniak, Bogdan; Wong McClure, Roy A.; Wong, Andrew; Wong, Tien Yin; Woo, Jean; Woodward, Mark; Wu, Frederick C.; Wu, Shouling; Wyszynska, Justyna; Xu, Haiquan; Xu, Liang; Yaacob, Nor Azwany; Yan, Weili; Yang, Ling; Yang, Xiaoguang; Yang, Yang; Yasuharu, Tabara; Ye, Xingwang; Yiallouros, Panayiotis K.; Yoosefi, Moein; Yoshihara, Akihiro; You, San Lin; Younger Coleman, Novie O.; Yusoff, Ahmad Faudzi; Zainuddin, Ahmad A.; Zakavi, Seyed Rasoul; Zamani, Farhad; Zambon, Sabina; Zampelas, Antonis; Elisa Zapata, Maria; Zaw, Ko Ko; Zdrojewski, Tomasz; Zejglicova, Kristyna; Vrkic, Tajana Zeljkovic; Zeng, Yi; Zhang, Luxia; Zhang, Zhen Yu; Zhao, Dong; Zhao, Ming Hui; Zhen, Shiqi; Zheng, Yingfeng; Zholdin, Bekbolat; Zhu, Dan; Zins, Marie; Zitt, Emanuel; Zocalo, Yanina; Zoghlami, Nada; Zuniga Cisneros, Julio; NCD Risk Factor CollaborationBackground Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories.