Browsing by Author "Giancaspero, R"
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- ItemAccuracy of invasive and noninvasive tests to diagnose Helicobacter pylori infection after antibiotic treatment(WILLIAMS & WILKINS, 1997) Rollan, A; Giancaspero, R; Arrese, M; Figueroa, C; Vollrath, V; Schultz, M; Duarte, I; Vial, PObjectives: To compare the diagnostic accuracy of the most widely available tests for diagnosis of Helicobacter pylori infection after antibiotic treatment, Methods: A total of 59 H, pylori-positive, duodenal ulcer patients (mean age, 40.7 +/- 11.7 yr; 40 male and 19 female) were treated for 2 wk with either amoxicillin-metronidazole (n = 36) or omeprazole-amoxicillin-tinidazole (n = 23), and after 4 wk, were tested for H, pylori infection by [C-14]urea breath test (UBT), serum IgG antibody level, and multiple antral biopsies for rapid urease testing, histology, Warthin-Starry stain, and polymerase chain reaction to detect H, pylori DNA, Infection status was established by a concordance of test results, Results: H, pylori was eradicated in 47 patients (80%), UBT and rapid urease testing had the best sensitivity and specificity, although not statistically different to Warthin-Starry stain and polymerase chain reaction, Serology and histology had little diagnostic value in this setting due to high proportion of false-positive results, Conclusions: Noninvasive UBT is as accurate in predicting H, pylori status after antibiotic treatment as rapid urease testing and Warthin-Starry stain, Especially for duodenal ulcer patients, UBT could be considered the gold standard to confirm eradication of H, pylori.