Browsing by Author "García-Huidobro Munita, Diego Nicolás"
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- ItemA cluster randomized trial of interferon ß-1a for the reduction of transmission of SARS-Cov-2: protocol for the Containing Coronavirus Disease 19 trial (ConCorD-19)(2021) Iturriaga, Carolina; Eiffler, Nat; Aniba, Rad; Pérez Mateluna, Guillermo; Meyer, Jessica K. V.; Severino Cuevas, Nicolás Felipe; Borzutzky Schachter, Arturo; Perret Pérez, Cecilia; Castro Rodríguez, José Antonio; García-Huidobro Munita, Diego Nicolás; Iturriaga, Carolina; Eiffler, Nat; Aniba, Rad; Pérez Mateluna, Guillermo; Meyer, Jessica K. V.; Severino Cuevas, Nicolás Felipe; Borzutzky Schachter, Arturo; Perret Pérez, Cecilia; Castro Rodríguez, José Antonio; García-Huidobro Munita, Diego Nicolás; Iturriaga, Carolina; Eiffler, Nat; Aniba, Rad; Pérez Mateluna, Guillermo; Meyer, Jessica K. V.; Severino Cuevas, Nicolás Felipe; Borzutzky Schachter, Arturo; Perret Pérez, Cecilia; Castro Rodríguez, José Antonio; García-Huidobro Munita, Diego Nicolás; Iturriaga, Carolina; Eiffler, Nat; Aniba, Rad; Pérez Mateluna, Guillermo; Meyer, Jessica K. V.; Severino Cuevas, Nicolás Felipe; Borzutzky Schachter, Arturo; Perret Pérez, Cecilia; Castro Rodríguez, José Antonio; García-Huidobro Munita, Diego NicolásAbstract Background SARS-CoV-2 infection rapidly spreads in populations due to the high rates of community transmission. Interrupting the shedding of SARS-CoV-2 may reduce the incidence of Coronavirus Disease 19 (COVID-19). Herein we provide a protocol for a cluster randomized trial that will examine the effectiveness of treatment with interferon (IFN) ß-1a compared to standard of care in limiting the transmission of SARS-CoV-2. Co-primary objectives are to determine whether IFN therapy reduces (a) the proportion of infected cases shedding SARS-CoV-2 at day 11 post randomization and (b) the incidence of transmission of SARS-CoV-2 infection from index cases to treatment-eligible household post-exposure contacts at day 11 after randomization. Secondary objectives include assessing the impact of IFN treatment on duration of viral clearance, hospitalizations and fatalities, and evaluating the safety of IFN treatment. Methods Three hundred and ten households, each including an index case with a recent COVID-19 diagnosis and at least one asymptomatic treatment-eligible household contact, will be randomized to receive 3 doses of 125 μg IFN ß-1a by subcutaneous administration (days 1, 6, and 11), or standard of care. All participants will be followed until day 29. Discussion The results from this trial will identify whether IFN ß treatment of mild or moderate COVID-19 cases accelerates viral clearance and prevents disease progression and whether IFN ß treatment of post-exposure contacts of COVID-19 cases reduces transmission of infection. Trial Registration: This trial is registered at ClinicalTrials.gov NCT04552379; date of registration September 17, 2020.
- ItemDesigning a mobile app to enhance parenting skills of latinx parents : a community-based participatory approach(2020) Doty, J. L.; Brady, S. S.; Popelka, J. M.; Rietveld, L.; García-Huidobro Munita, Diego Nicolás; Doty, M. J.; Linares, R.; Svetaz, M. V.; Allen, M. L.
- ItemEffect of Patient-Centered Medical Home on Preventive Services for Adolescents and Young Adults(2016) García-Huidobro Munita, Diego Nicolás; Shippee, Nathan; Dicaprio, Julia Joseph; O'Brian, Jenniffer; Svetaz, María Verónica
- ItemEffective Parenting Interventions to Reduce Youth Substance Use : A Systematic Review(2016) Allen, M.; García-Huidobro Munita, Diego Nicolás; Porta, C.; Curran, D.; Patel, R.; Miller, J.; Borowsky, I.
- ItemIncreased rates of parental separation and anxiety among Latinx youth(2020) Brown, C. R.; Shramko, M.; García-Huidobro Munita, Diego Nicolás; Miller, K. K.; Brar, P.; Ogugua, F.; Svetaz, M. V.
- ItemLearning Together to Work Together : Interprofessional Education for Students in a Primary Care Setting in Chile(2013) García-Huidobro Munita, Diego Nicolás; Skewes, S.; Barros, X.; Pizarro, C.; Gawinski, B.
- ItemMixed-methods evaluation of the initial implementation of advanced home visits in Chile(2022) García-Huidobro Munita, Diego Nicolás; Vergés, Álvaro; Basualto, Patricia; Calvo Miranda, Carlos; Boetto Puebla, Carolina; Soto, Mauricio; Kopplin Ibáñez, Erika Blanca; Martínez Pérez, Mayra Alicia; Aracena Álvarez, MarcelaHome visiting programs are evidence-based interventions that have a myriad outcomes for mothers and newborns. Chile offers these services as part of the Chile Crece Contigo, a nationwide program. However, implementing home visiting programs in community settings is difficult. In this study, we report clinic, provider, and participant engagement with the implementation of advanced home visits (ViDAs) in Chilean primary care clinics. ViDAs include a high number of visits, external supervision, and the use of technology. In this study, qualitative and quantitative data were collected to assess the initial implementation of the home visiting strategy. Qualitative data consisted of individual interviews and focus groups with directors of city health departments, clinic managers, and providers conducting home visits. Quantitative data included clinic, provider, and participant recruitment. City health departments were approached to authorize the participation of primary care clinics in the ViDAs program. Then, clinic directors were invited to approve the implementation of the home visiting program at their health centers. In total, 16 clinics, 42 practitioners, and 185 participants were recruited. A large amount of resources was needed to recruit clinics, providers, and participants. The intervention had low acceptability, low adoption, and a high implementation cost. Initial program implementation experienced several challenges. Identified facilitators and barriers both highlighted the need for community engagement at all levels for the successful implementation of an innovation in Chilean primary care clinics. In addition, this article provides recommendations for practitioners and researchers regarding the conduct of research in community-based settings.
- ItemParents and Family Matter Strategies for Developing Family-Centered Adolescent Care Within Primary Care Practices(2014) Svetaz, M.; García-Huidobro Munita, Diego Nicolás; Allen, M.
- ItemPerceived importance and interest in research by Chilean primary care providers(2023) García-Huidobro Munita, Diego Nicolás; Aracena Álvarez, Marcela; Bravo Valenzuela, Paulina Fabiola; González, Karla; Soto, Mauricio; von Borries, Pamela; Sapag, Jaime C.Background: Primary care providers (PCPs) are relevant stakeholders for primary care research (PCR). Objective: We report the perceived importance and interest in PCR of a national sample of Chilean PCPs. Methods: We conducted a cross-sectional study targeting Chilean PCPs. An electronic survey assessing perceived relevance of PCR, research training and experience, training interests, and demographics was disseminated through emails and WhatsApp messages. Descriptive statistics were used to summarize data. Logistic regression models were used to estimate adjusted probabilities and 95% confidence intervals for high interest in PCR, high interest in using research methods, and high interest in receiving research training, and predictors of these outcomes. Results: A total of 387 providers completed the online survey. Only 26.4% of PCPs had research experience as a principal or co-investigator. However, most clinicians perceived PCR as very important (92.5%) and were interested in using research methods (90.7%) and receiving training (94.3%). There were no statistically significant differences in these perceptions between provider’s discipline, role, sex, age, and geographical location after adjusting for covariates. Conclusions: Despite few Chilean PCPs have research training, a large majority perceive it as important, are interested in using it in their practice and would like to receive training.
- ItemResearch on Clinical Preventive Services for Adolescents and Young Adults: Where Are We and Where Do We Need to Go?(2017) Harris, Sion K.; Aalsma, Matthew C.; Weitzman, Elissa; García-Huidobro Munita, Diego Nicolás; Wong, Charlene; Hadland, Scott E.; Santelli, John; Park, M. Jane; Ozer, Elizabeth M.
- ItemSqueezing observational data for better causal inference : methods and examples for prevention research(2016) García-Huidobro Munita, Diego Nicolás; Oakes, J. Michael
- ItemVasomotion in Human Umbilical and Placental Veins: Role of Gap Junctions and Intracellular Calcium Reservoirs in Their Synchronous Propagation(2007) García-Huidobro Munita, Diego Nicolás; Huidobro-Toro, Juan Pablo.