Browsing by Author "García B., Cristián"
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- ItemPancreatitis aguda recurrente, caso clínico(2007) Argollo Mamani, Pamela Denise; García B., Cristián; Harris D., Paul R.Background: Recurrent acute pancreatitis (RAP) is defined as episodes of acute pancreatitis with complete clinical and anatomical resolution between each episode. The etiology is diverse in children (20-35% unknown). Objective: Analyze the etiology, diagnosis and most appropriate screening of RAP in children. Case-report: A 9 year-old boy with 6 episodes of acute pancreatitis (AP); 4 of them required hospital admission. The study included a normal colangiopancreatography, normal basic immunologic and metabolic exams and negative genetic assessment of the cystic fibrosis' most common mutation. During the episodes of AP, 3 computed tomography images were obtained and showed AP in different degrees (Baltasar C and E). Genetic testing for hereditary pancreatitis was negative. Laparoscopic colecistectomy was performed. Conclusion: RAP must be suspected in children with recurrent abdominal pain and elevated serum amylase-lipase concentration, in order to initiate an adequate evaluation. © 2007 Sociedad Chilena de Pediatría
- ItemRelation between body composition trajectories from childhood to adolescence and nonalcoholic fatty liver disease risk(2024) Alberti, Gigliola; Faune Palacios, Mariana Carmen; Santos Martín, José Luis; De Barbieri Magnone, Florencia Beatriz; García B., Cristián; Pereira, Ana; Becerra, Fernando; Gana Ansaldo, Juan CristóbalNAFLD has become the leading cause of chronic liver disease in children, as a direct consequence of the high prevalence of childhood obesity. This study aimed to characterize body composition trajectories from childhood to adolescence and their association with the risk of developing nonalcoholic fatty liver disease (NAFLD) during adolescence. The participants were part of the ‘Chilean Growth and Obesity Cohort Study’, comprising 784 children who were followed prospectively from age 3 years. Annual assessments of nutritional status and body composition were conducted, with ultrasound screening for NAFLD during adolescence revealing a 9.8% prevalence. Higher waist circumference measures were associated with NAFLD from age 3 years (p = 0.03), all skin folds from age 4 years (p < 0.01), and DXA body fat measurements from age 12 years (p = 0.01). The fat-free mass index was higher in females (p = 0.006) but not in males (p = 0.211). The second and third tertiles of the fat mass index (FMI) had odds ratios for NAFLD during adolescence of 2.19 (1.48–3.25, 95% CI) and 6.94 (4.79–10.04, 95% CI), respectively. Elevated waist circumference, skin folds, and total body fat were identified as risk factors for future NAFLD development. A higher FMI during childhood was associated with an increased risk of NAFLD during adolescence.
- ItemSkeletal dysplasias in Latin America(2020) Cavalcanti, Denise P.; Fano, Virginia; Mellado Sagredo, Cecilia Ximena Del Carmen; Lacarrubba‐Flores, María Dora; Silveira, Cynthia; Silveira, Karina C.; Pino, Mariana del; Moresco, Angélica; Caino, Silvia; Ramos Mejía, Rosario; García B., Cristián; Lay-Son Rodríguez, Guillermo Roberto; Ferreira, Carlos F.Skeletal dysplasias (SD) are disturbances in growth due to defects intrinsic to the bone and/or cartilage, usually affecting multiple bones and having a progressive character. In this article, we review the state of clinical and research SD resources available in Latin America, including three specific countries (Brazil, Argentina, and Chile), that have established multidisciplinary clinics for the care of these patients. From the epidemiological point of view, the SD prevalence of 3.2 per 10,000 births from nine South American countries included in the ECLAMC network represents the most accurate estimate not just in Latin America, but worldwide. In Brazil, there are currently five groups focused on SD. The data from one of these groups including the website www.ocd.med.br, created to assist in the diagnosis of SD, are highlighted showing that telemedicine for this purpose represents a good strategy for the region. The experience of more than 30 years of the SD multidisciplinary clinic in an Argentinian Hospital is presented, evidencing a solid experience mainly in the follow-up of the most frequent SD, especially those belonging the FGFR3 group and OI. In Chile, a group with 20 years of experience presents its work with geneticists and pediatricians, focusing on diagnostic purposes and clinical management. Altogether, although SD health-care and research activities in Latin America are in their early stages, the experience in these three countries seems promising and stimulating for the region as a whole.
- ItemTiroides lingual como causa de disfagia. Caso clínico(2008) Rocha-Ruiz, Ana; Beltrán, Constanza; Harris, Paul R.; Orellana Martínez, Pilar; García B., Cristián; Martínez Aguayo, AlejandroWe report a 11 year-old boy who presented with difficulty in swallowing without symptoms of hypothyroidism. The physical examination revealed a mass at the base of the tongue. The thyroid hormone profile showed a primary hypothyroidism (a serum TSH of 10.8 IU/mL with normal-low thyroxin of 6.0 μg/dL and low triiodothyronine of 57.8 ng/ dL). Antithyroid antibodies were negative. The fiberoptic endoscopy showed a reddish mass, without evidence of haemorrhage or ulceration, confirmed as a well circumscribed, hypodense mass in the base of the tongue by computed tomography of the oropharynx and neck. Tc-99-pertechnetate scanning showed an abnormal area of uptake at the base of the tongue and no uptake in the normal thyroid location, concordant with an ectopic lingual thyroid gland. Levothyroxine in a suppressive dose was started that resulted in a reduction of the size of the mass and disappearance of dysphagia.