Browsing by Author "Gabrielli Nervi, Luigi Arnaldo"
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- ItemCirculating Vascular Cell Adhesion Molecule-1 (sVCAM-1) Is Associated With Left Atrial Remodeling in Long-Distance Runners(FRONTIERS MEDIA SA, 2021) Contreras Briceño, Felipe; Herrera, Sebastián; Vega Adauy, Julián; Salinas, Manuel; Ocaranza Jeraldino, María Paz; Jalil Milad, Jorge; Mandiola Ovalle, Jorge; García, Lorena; Chiong, Mario; Castro Galvez, Pablo Federico; Lavandero, Sergio; Gabrielli Nervi, Luigi ArnaldoIntroduction: An increased risk of atrial fibrillation (AF) has been demonstrated in high-performance athletes. Soluble vascular adhesion molecule-1 (sVCAM-1), a biomarker involved in inflammation and cardiac remodeling, is associated with the development of AF in the general population. However, the relationship between sVCAM-1 and left atrial (LA) remodeling has been poorly investigated in long-distance runners (LDR).Aim: To determine the association between LA remodeling and sVCAM-1 levels in LDR during the training period before a marathon race.Methods: Thirty-six healthy male LDR (37.0 +/- 5.3 years; 174.0 +/- 7.0 height; BMI: 23.8 +/- 2.8; V degrees O-2-peak: 56.5 +/- 7.3 mL center dot kg(-1)center dot min(-1)) were evaluated in this single-blind and cross-sectional study. The LDR were separated into two groups according to previous training levels: high-training (HT) (n = 18) >= 100 km center dot week(-1) and low-training (LT) (n = 18) >= 70 and <100 km center dot week(-1). Also, 18 healthy non-active subjects were included as a control group (CTR). In all participants, transthoracic echocardiography was performed. sVCAM-1 blood levels were measured baseline and immediately finished the marathon race in LDR.Results: HT showed increased basal levels of sVCAM-1 (651 +/- 350 vs. 440 +/- 98 ng center dot mL(-1) CTR, p = 0.002; and vs. 533 +/- 133 ng center dot mL(-1) LT; p = 0.003) and a post-marathon increase (Delta sVCAM-1) (651 +/- 350 to 905 +/- 373 ng center dot mL(-1); p = 0.002), that did not occur in LT (533 +/- 133 to 651 +/- 138 ng center dot mL(-1); p = 0.117). In LDR was a moderate correlation between LA volume and sVCAM-1 level (rho = 0.510; p = 0.001).Conclusions: In male long-distance runners, sVCAM-1 levels are directly associated with LA remodeling. Also, the training level is associated with basal sVCAM-1 levels and changes after an intense and prolonged exercise (42.2 km). Whether sVCAM-1 levels predict the risk of AF in runners remains to be established.
- ItemDetermination of the Respiratory Compensation Point by Detecting Changes in Intercostal Muscles Oxygenation by Using Near-Infrared Spectroscopy(MDPI, 2022) Contreras Briceño, Felipe; Espinosa Ramírez, Maximiliano; Keim Bagnara, Vicente; Carreño Roman, Matías Ignacio; Rodríguez Villagra, Rafael Alejandro; Villegas Belmar, Fernanda; Viscor, Gines; Gabrielli Nervi, Luigi Arnaldo; Andia, Marcelo E.; Araneda, Oscar F.; Hurtado, Daniel E.This study aimed to evaluate if the changes in oxygen saturation levels at intercostal muscles (SmO2 m.intercostales) assessed by near-infrared spectroscopy (NIRS) using a wearable device could determine the respiratory compensation point (RCP) during exercise. Fifteen healthy competitive triathletes (eight males; 29 +/- 6 years; height 167.6 +/- 25.6 cm; weight 69.2 +/- 9.4 kg; (V) over dotO(2)-max 58.4 +/- 8.1 mL.kg(-1).min(-1)) were evaluated in a cycle ergometer during the maximal oxygen-uptake test ((V) over dotO(2)-max), while lung ventilation ((V) over dotE), power output (watts, W) and SmO2 mantercostales were measured. RCP was determined by visual method (RCPvisual : changes at ventilatory equivalents ((V) over dotE.CO2-1, (V) over dotE.(V) over dotO(2)(-1)) and end-tidal respiratory pressure (PetO(2), PetCO(2)) and NIRS method (RCP NIRS : breakpoint of fall in SmO2 m.intercostales). During exercise, SmO2 m.intercostales decreased continuously showing a higher decrease when (V) over dotE increased abruptly. A good agreement between methods used to determine RCP was found (visual vs NIRS) at %(V) over dotO(2)-max, (V) over dotO(2), (V) over dotE, and W (Bland-Altman test). Correlations were found to each parameters analyzed (r = 0.854; r = 0.865; r = 0.981; and r = 0,968; respectively. p < 0.001 in all variables, Pearson test), with no differences (p < 0.001 in all variables, Student's t-test) between methods used (RCPvisual and RCPNIRS). We concluded that changes at SmO2 m.intercostales measured by NIRS could adequately determine RCP in triathletes.
- ItemReverse Remodeling in Human Heart Failure after Cardiac Resynchronization Therapy Is Associated With Reduced RHO-Kinase Activation(2021) Ocaranza Jeraldino, Maria Paz; Jalil Milad, Jorge Emilio; Altamirano Assad, Rodrigo Patricio; De León Soto, Ana María; Moya López, Jackeline Trinidad; Lonis Álvarez, María Alejandra; Gabrielli Nervi, Luigi Arnaldo; Mac Nab, Paul; Cordova Alvestegui, Samuel Edmundo; Paredes, Alejandro; Vergara Saavedra, Ismael Antonio; Bittner Braemer, Alex Gerhard; Sabat Sarras, Karime Alejandra; Pastorini, Karla["Background: Reverse remodeling is a clinically relevant endpoint in heart failure with reduced ejection fraction (HFrEF). Rho-kinase (ROCK) signaling cascade activation correlates with cardiac remodeling and left ventricular (LV) systolic dysfunction in HFrEF patients. Cardiac resynchronization therapy (CRT) is effective in HFrEF, especially when there is a left bundle block, as this treatment may stimulate reverse remodeling, thereby improving quality of life and prolonging survival for patients with this severe condition. Here, we evaluate the hypothesis that ROCK activation is reduced after effective CRT in HFrEF.", "Methods: ROCK activation in circulating leukocytes was evaluated in 28 HFrHF patients, using Western blot (myosin light chain phosphatase subunit 1 phosphorylation, MYPT1p/t), before and three months after initiation of CRT. LV systolic function and remodeling were assessed by echocardiography.", "Results: Three months after CRT, LV ejection fraction increased an average of 14.5% (p < 0.001) in 13 patients (responders), while no change was observed in 15 patients (non-responders). End-systolic diameter decreased 16% (p < 0.001) in responders, with no change in non-responders. ROCK activation in PBMCs decreased 66% in responders (p < 0.05) but increased 10% in non-responders (NS). LV end-diastolic diameter was also 5.2 mm larger in non-responders vs. responders (p = 0.058). LV ejection fraction, systolic diameter, and ROCK activation levels were similar in both groups at baseline.", "Conclusion: In HFrEF patients, 3 months of effective CRT induced reverse myocardial remodeling, and ROCK activation was significantly decreased in circulating leukocytes. Thus, decreased ROCK activation in circulating leukocytes may reflect reverse cardiac remodeling in patients with heart failure."]