Browsing by Author "GUILOFF, E"

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    ATTEMPTS TO PROGRAM OVULATION WITH EXOGENOUS ESTROGENS AND LH-RH ANALOGUE
    (1975) ZANARTU, J; ROSNER, JM; GUILOFF, E; IBARRAPOLO, AA; CROXATTO, HD; CROXATTO, HB; AGUILERA, E; COY, DH; SCHALLY, AV
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    ENDOCRINE RESPONSE AND OVUM TRANSPORT IN WOMEN TREATED WITH D-TRP6-LUTEINIZING HORMONE-RELEASING HORMONE IN THE POST-OVULATORY PERIOD
    (1982) GUILOFF, E; SALVATIERRA, AM; ORTIZ, ME; CROXATTO, HB
    Possible alterations in ovum transport during increased activity of the hypothalamic-pituitary-ovarian axis were investigated in women. D-Trp6-LHRH, a synthetic peptide with potent gonadotropin-releasing activity, was used to induce a gonadotropin surge and stimulate ovarian steroid secretion in the postovulatory phase. The compound was administered i.m. or i.v. 24, 48 or 72 h following the maximum preovulatory lutropin level in plasma in 7 women. An immediate and pronounced gonadotropin surge accompanied by a moderate increase in the estradiol and progesterone level was obtained in all cases. Ova were recovered from the fallopian tubes in 4 of the 7 women 24 h following treatment. The rate of recovery and the location of ova within the genital tract indicate that the treatment and the resulting endocrine changes failed to accelerate migration of the ova toward the uterus. In comparison with other mammals transport of the ovum in the woman is relatively insensitive to endocrine changes occurring in the postovulatory phase.