Browsing by Author "Fodor, D."
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- ItemCongenital hepatic fibrosis. Report of five cases.(2004) Harris, Paul R.; Fodor, D.; Cavagnaro, F.; Di Egidio, M.; Duarte, I.; Fava, M.Background. Congenital hepatic fibrosis (CHF) is an autosomic dominant disease that has been associated with polycystic kidney disease. Aim: To describe the medical management of 5 children with CHF and to evaluate the presence and extension of the associated renal disease. Patients and methods: Retrospective review of the medical charts of 5 children with CHF, aged 2 to 14 years. Results: Three children presented autosomic recessive polycystic kidney disease, which was diagnosed before the appearance of liver disease manifestations. They presented a more severe liver damage, with a more aggressive clinical course requiring use of transjugular intrahepatic porto-systemic shunts (TIPS) or surgical porto-systemic shunts to control portal hypertension. The other two children, in whom the diagnosed was based on asymptomatic hepatomegaly, had normal renal function and structure with a more benign clinical course. Conclusions: The diagnosis of CHF should be suspected not only in children with polycystic kidney disease but in those children with persistent, hard consistency, left lobe predominance hepatomegaly.
- ItemFibrosis Hepática congénita: un espectro clínico variable: Casos clínicos(2004) Harris, Paul R.; Fodor, D.; Cavagnaro, F.; Di Egidio, M.; Fava, M.Background: Congenital hepalic fibrosis (CHF) is an autosomic dominant disease that has been associated will polycistic kidney disease. Aim. To describe The medical managment of 5 children with CHF and to evaluate the presence and extension of the associated renal disease. Patients and methods. Retrospective review of the medical charts of 5 children with CHF aged 2 to 14 years. Results: Three children presented autosomic recessive polycistic kidney disease, which was diagnosed before the appearance of liver disease manifestations. They presented a more severe liver damage with a more aggressive clinical course requiring use of transjugular intrahepatic porto-systemic shunts (TIPS) or surgical porto-systemic shunts to control portal hypertension. The other two children, in whom the diagnosed was based on asymptomatic hepatomegaly had normal renal function and structure with a more benign clinical course. Conclusions: The diagnosis of CHT should be suspected not only in children with polycystic kidney disease but in those children with persistent, hard consistently, left lobe predominance hepatomegaly.