Browsing by Author "Ferreccio Readi, Catterina"

Now showing 1 - 20 of 80
  • Thumbnail Image
    Item
    A 'Polypill' Aimed At Preventing Cardiovascular Disease Could Prove Highly Cost-Effective For Use In Latin America
    (2013) Bautista, Leonelo; Vera Cala, Lina; Ferrante, Daniel; Herrera, Víctor M.; Miranda, J. Jaime; Pichardo, Rafael; Sánchez Abanto, José R.; Ferreccio Readi, Catterina; Bautista, Leonelo; Vera Cala, Lina; Ferrante, Daniel; Herrera, Víctor M.; Miranda, J. Jaime; Pichardo, Rafael; Sánchez Abanto, José R.; Ferreccio Readi, Catterina
  • Thumbnail Image
    Item
    A comparison of single and combined visual, cytologic, and virologic tests as screening strategies in a region at high risk of cervical cancer
    (AMER ASSOC CANCER RESEARCH, 2003) Ferreccio Readi, Catterina; Bratti, María C.; Sherman, Mark E.; Herrero, Rolando; Marshall Rivera, Guillermo; Wacholder, Sholom; Hildesheim, Allan; Burk, Robert D.; Hutchinson, Martha; Alfaro, Mario; Greenberg, Mitchell D.; Morales, Jorge; Rodríguez, Ana C.; Schussler, John; Eklund, Claire; Schiffman, Mark
  • Thumbnail Image
    Item
    A snapshot of cancer in Chile: analytical frameworks for developing a cancer policy
    (2015) Jiménez de la Jara, Jorge; Bastías, Gabriel; Ferreccio Readi, Catterina; Moscoso, Cristián; Sagués, Sofía; Cid Pedraza, Camilo; Bronstein, Eduardo; Herrera Riquelme, Cristian Alberto; Nervi, Bruno; Corvalán R., Alejandro; Jiménez de la Jara, Jorge; Bastías, Gabriel; Ferreccio Readi, Catterina; Moscoso, Cristián; Sagués, Sofía; Cid Pedraza, Camilo; Bronstein, Eduardo; Herrera Riquelme, Cristian Alberto; Nervi, Bruno; Corvalán R., Alejandro
  • Thumbnail Image
    Item
    Acute myocardial infarction mortality in comparison with lung and bladder cancer mortality in arsenic-exposed region II of Chile from 1950 to 2000
    (2007) Yuan, Yan; Marshall Rivera, Guillermo; Ferreccio Readi, Catterina; Steinmaus, Craig; Selvin, Steve; Liaw, Jane; Bates, Michael N.; Smith, Allan H.
  • Thumbnail Image
    Item
    Age at Exposure to Arsenic in Water and Mortality 30-40 Years After Exposure Cessation
    (OXFORD UNIV PRESS INC, 2018) Roh, Taehyun; Steinmaus, Craig; Marshall Rivera, Guillermo; Ferreccio Readi, Catterina; Liaw, Jane; Smith, Allan H.
  • Thumbnail Image
    Item
    Anticonceptivos hormonales y enfermedad cardiovascular en pre y post menopausia : Molina, 2014-2018
    (2021) Soto Marchant, Mario Elías; Ferreccio Readi, Catterina; Pontificia Universidad Católica de Chile. Escuela de Medicina
    Si bien en promedio las mujeres tienen menor riesgo de enfermedad cardiovascular (ECV) que los hombres, su riesgo varía con la edad, aumentando en post-menopausia. Recientemente se ha reportado en Estados Unidos un aumento de muertes cardiovasculares en mujeres premenopáusicas, mencionando entre las posibles causas obesidad, tabaquismo, sedentarismo, así como también un aumento del uso de anticonceptivos hormonales (ACH). Objetivo: Evaluar la asociación del uso de ACH con la iniciación de ECV crónica en la pre-menopausia versus post-menopausia. Hipótesis: El uso de ACH, mediante la inhibición de la función ovárica, revertirá la protección natural asociada a las hormonas sexuales, aumentando el riesgo de ECV a edades más tempranas. Su efecto será mayor a mayor exposición. Métodos: estudio transversal, anidado en la cohorte de mujeres del estudio MAUCO, en quienes se evaluó al ingreso la exposición a anticoncepción, el antecedente de ECV crónica (hipertensión arterial (HTA) y diabetes mellitus (DM)) y los factores de riesgo clásicos de ECV. La muestra consistió en 4.013 mujeres >35 años ingresadas a MAUCO entre los años 2014 y 2018, con registro completo de los antecedentes anteriormente mencionados. Para evaluar la asociación entre el uso de ACH con HTA y DM, se generó un modelo predictivo del uso de ACH. Las variables que lo integraron se utilizaron para estimar un puntaje de propensión (propensity score, PS) del uso de ACH. Este PS fue introducido como variable de ponderación en modelos de regresión logística. La ECV fue explicada mediante el uso real de ACH, el PS, y por las variables confundentes identificadas en los grafos causales construidos según los factores confundentes reportados en la literatura. Resultados: Entre las 4.013 mujeres de la cohorte, 2.313 (57,6%) reportó haber utilizado alguna vez ACH y 1.969 (49,1%) reportó alguna ECV crónica (sólo HTA: 33,8%, sólo DM: 4,0%, HTA y DM: 11,3%). Las usuarias de ACH eran más jóvenes (4 años menos) respecto a las no usuarias, tenían menor prevalencia de: obesidad (-5%), colelitiasis (-3%), HTA (-8,2%) y DM (-3,5%), sin diferencias en el perfil lipídico ni consumo de tabaco. Las usuarias de ACH refirieron mayormente haber estado alguna vez embarazadas (98,1% vs 92,8% en no usuarias), así como también mayor escolaridad (54,5% con enseñanza media o superior vs 44,7%), mayor ingreso familiar mensual (23,3% con >$250.000 vs 21,7%) y vivían más en pareja (casadas o conviviendo 64,8% vs 57,8%). Las variables significativamente predictoras de uso de ACH fueron (OR, IC95%): edad (0,95, 0,95-0,96), índice de masa corporal (IMC) (0,98, 0,97-0,99), consumo actual de tabaco (0,79, 0,68-0,91), gestaciones (1,23, 1,14-1,33), años de estudio (1,05, 1,03-1,06) y citología cervical anormal (1,57, 1,28-1,94). Todas ellas fueron incorporadas en el PS. Se probaron diferentes modelos explicativos de ECV, para HTA, DM y ambas patologías por uso de ACH, incluyendo o excluyendo el PS, edad, consumo de tabaco, nivel educacional y uso de terapia de reemplazo hormonal (TRH), en ninguno de los cuales el uso de ACH resultó significativo. Conclusión: No se demostró asociación entre el uso de ACH y ECV crónica en MAUCO ajustando por las variables definidas. La naturaleza transversal del estudio no permite descartar causalidad reversa. Palabras clave: anticoncepción hormonal, menopausia, enfermedad cardiovascular.
  • Thumbnail Image
    Item
    Arsenic methylation and lung and bladder cancer in a case-control study in northern Chile
    (2014) Melak, Dawit; Ferreccio Readi, Catterina; Kalman, David; Parra, Roxana; Acevedo, Johanna; Pérez, Liliana; Cortés Arancibia, Sandra; Smith, Allan H.; Yuan, Yan; Liaw, Jane
  • Thumbnail Image
    Item
    Arsenic, Tobacco Smoke, and Occupation Associations of Multiple Agents with Lung and Bladder Cancer
    (2013) Ferreccio Readi, Catterina; Yuan, Yan; Calle, Jacqueline; Benítez, Hugo; Parra, Roxana L.; Acevedo, Johanna; Smith, Allan H.; Liaw, Jane; Steinmaus, Craig
  • Thumbnail Image
    Item
    Assessment of Gastritis and Gastric Cancer Risk in the Chilean Population Using the OLGA System
    (2019) Bellolio, Enrique; Riquelme, Ismael; Riffo Campos, Angela L.; Rueda, Carlos; Ferreccio Readi, Catterina; Villaseca, Miguel; Brebi, Priscilla; Muñoz, Sergio R.; Araya, Juan Carlos
  • Thumbnail Image
    Item
    Association of Aflatoxin and Gallbladder Cancer
    (2017) Koshiol, Jill; Gao, Yu-Tang; Dean, Michael; Egner, Patricia; Nepal, Chirag; Jones, Kristine; Wang, Bingsheng; Rashid, Asif; Luo, Wen; Ferreccio Readi, Catterina; Van Dyke, Alison; Malasky, Michael; Shen, Ming-Chang; Zhu, Bin; Andersen, Jesper B.; Hildesheim, Allan; Hsing, Ann W.; Groopman, John
  • Thumbnail Image
    Item
    Association of inflammatory and other immune markers with gallbladder cancer : Results from two independent case-control studies
    (2016) Pinto, L.; Koshiol, J.; Castro, F.; Kemp, T.; Gao, Y.; Roa Strauch, Juan Carlos Enrique; Wang, B.; Nogueira, L.; Araya, J.; Ferreccio Readi, Catterina; Rashid, A.; Hsing, A.; Hildesheim, A.; Shen, M.; Pfeiffer, R.
  • Thumbnail Image
    Item
  • Thumbnail Image
    Item
    Associations of six adiposity-related markers with incidence and mortality from 24 cancers—findings from the UK Biobank prospective cohort study
    (2021) Parra Soto, Solange; Ferreccio Readi, Catterina; Cowley, Emma S.; Rezende, Leandro F. M.; Mathers, John C.; Pell, Jill P.; Ho, Frederick K.; Celis Morales, Carlos
    Abstract Background Adiposity is a strong risk factor for cancer incidence and mortality. However, most of the evidence available has focused on body mass index (BMI) as a marker of adiposity. There is limited evidence on relationships of cancer with other adiposity markers, and if these associations are linear or not. The aim of this study was to investigate the associations of six adiposity markers with incidence and mortality from 24 cancers by accounting for potential non-linear associations. Methods A total of 437,393 participants (53.8% women; mean age 56.3 years) from the UK Biobank prospective cohort study were included in this study. The median follow-up was 8.8 years (interquartile range 7.9 to 9.6) for mortality and 9.3 years (IQR 8.6 to 9.9) for cancer incidence. Adiposity-related exposures were BMI, body fat percentage, waist-hip ratio, waist-height ratio, and waist and hip circumference. Incidence and mortality of 24 cancers sites were the outcomes. Cox proportional hazard models were used with each of the exposure variables fitted separately on penalised cubic splines. Results During follow-up, 47,882 individuals developed cancer and 11,265 died due to cancer during the follow-up period. All adiposity markers had similar associations with overall cancer incidence. BMI was associated with a higher incidence of 10 cancers (stomach cardia (hazard ratio per 1 SD increment 1.35, (95% CI 1.23; 1.47)), gallbladder (1.33 (1.12; 1.58)), liver (1.27 (1.19; 1.36)), kidney (1.26 (1.20; 1.33)), pancreas (1.12 (1.06; 1.19)), bladder (1.09 (1.04; 1.14)), colorectal (1.10 (1.06; 1.13)), endometrial (1.73 (1.65; 1.82)), uterine (1.68 (1.60; 1.75)), and breast cancer (1.08 (1.05; 1.11))) and overall cancer (1.03 (1.02; 1.04)). All these associations were linear except for breast cancer in postmenopausal women. Similar results were observed when other markers of central and overall adiposity were used. For mortality, nine cancer sites were linearly associated with BMI and eight with waist circumference and body fat percentage. Conclusion Adiposity, regardless of the marker used, was associated with an increased risk in 10 cancer sites.
  • Thumbnail Image
    Item
    Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?
    (2018) Pena-Oyarzun, Daniel; Bravo-Sagua, Roberto; Diaz-Vega, Alexis; Aleman, Larissa; Chiong, Mario; Garcia, Lorena; Bambs S., Claudia; Troncoso, Rodrigo; Cifuentes, Mariana; Morselli, Eugenia; Ferreccio Readi, Catterina; Quest, Andrew F. G.; Criollo, Alfred
  • Thumbnail Image
    Item
    Baseline assessment of prevalence and geographical distribution of HPV types in Chile using self-collected vaginal samples
    (2008) Ferreccio Readi, Catterina; Corvalán R., Alejandro; Margozzini Maira, Paula; Viviani García, Paola; González, Claudia; Aguilera, Ximena; Gravitt, Patti E
    Abstract Background Chile has broad variations in weather, economics and population from the far desert north (Region 1) to the cold, icy south (Region 12). A home-based self-collected vaginal sampling was nested in the 2003 Chilean population-based health survey in order to explore the possibility of a type-specific geographical variation for human papillomavirus Methods The population was a national probability sample of people 17 years of age and over. Consenting women provided self-collected cervicovaginal swabs in universal collection media (UCM). DNA was extracted and typed to 37 HPV genotypes using PGMY consensus PCR and line blot assay. Weighted prevalence rates and adjusted OR were calculated. Results Of the 1,883 women participating in the health survey, 1,219 (64.7%) provided a cervicovaginal sample and in 1,110 (56.2% of participants and 66.5% of those eligible) the samples were adequate for analysis. Refusal rate was 16.9%. HPV prevalence was 29.2% (15.1% high-risk HPV and 14.1% low-risk HPV). Predominant high-risk types were HPV 16, 52, 51, 56 and 58. Predominant low-risk HPVs were HPV 84, CP6108, 62, 53 and 61. High-risk and low-risk HPV rates were inversely correlated between the regions. High-risk HPV prevalence was highest among the youngest women, whereas low-risk HPV increased slightly with age. Conclusion Self-obtained vaginal sampling is adequate for monitoring HPV in the community, for identifying high-risk areas, and for surveying the long term impact of interventions.
  • Thumbnail Image
    Item
    Case-Control Study of Arsenic in Drinking Water and Kidney Cancer in Uniquely Exposed Northern Chile
    (2013) Ferreccio Readi, Catterina; Smith, Allan H.; Durán, Viviana; Barlaro, Teresa; Benítez, Hugo; Valdés, Rodrigo O.; Aguirre, Juan José; Moore, Lee E.; Acevedo, Johanna; Vásquez, María Isabel; Pérez, Liliana; Yuan, Yan; Liaw, Jane; Cantor, Kenneth P.; Steinmaus, Craig
  • Thumbnail Image
    Item
    Case-Control Study of Risk Factors for Meningococcal Disease in Chile
    (2017) Olea, Andrea; Matute, Isabel; González, Claudia; Delgado, Iris; Poffald, Lucy; Pedroni, Elena; Alfaro, Tania; Hirmas, Macarena; Nájera, Manuel; Ferreccio Readi, Catterina; Gormaz, Ana; López, Darío; Loayza, Sergio; Gallegos, Doris; Fuentes, Rodrigo; Vial, Pablo; Aguilera, Ximena
  • Thumbnail Image
    Item
    Chlorine isotopic composition of perchlorate in human urine as a means of distinguishing among exposure sources
    (2015) Poghosyan, Armen; Morel-Espinosa, Maria; Valentin-Blasini, Liza; Blount, Benjamin C.; Ferreccio Readi, Catterina; Steinmaus, Craig M.; Sturchio, Neil C.
  • Thumbnail Image
    Item
    Circulating Arsenic is Associated with Long-Term Risk of Graft Failure in Kidney Transplant Recipients : A Prospective Cohort Study
    (2020) Sotomayor, C. G.; Groothof, D.; Vodegel, J. J.; Gacitua, T. A.; Gomes Neto, A. W.; Oste, M. C. J.; Pol, R. A.; Ferreccio Readi, Catterina; Berger, S. P.; Chong, G.; Slart, R. H. J. A.; Rodrigo, R.; Navis, G. J.; Touw, D. J.; Bakker, Jan
  • Thumbnail Image
    Item
    Cohort Profile : The Maule Cohort (MAUCO)
    (2020) Ferreccio Readi, Catterina; Huidobro, A.; Cortés Arancibia, Sandra; Bambs S., Claudia; Toro Espinoza, Pablo Esteban; Van De Wyngard, Vanessa; Acevedo Romo, Johanna Patricia; Verdejo Pinochet, Hugo; Cook, María Paz; Castro Gálvez, Pablo Federico; Cruz Olivos, Francisco; Corvalán R., Alejandro; Paredes, F.; Venegas, P.; Oyarzún González, X.; Foerster, C.; Vargas, C.; Koshiol, J.; Araya, J. C.; Quest, A. F.; Kogan, M. J.; Lavandero, S.; MAUCO Study Group