Browsing by Author "Ferrada, Marcela"

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    A wireless pressure sensor for monitoring pulmonary artery pressure in advanced heart failure: Initial experience
    (ELSEVIER SCIENCE INC, 2007) Castro, Pablo F.; Concepcion, Roberto; Bourge, Robert C.; Martinez, Alejandro; Alcaino, Milton; Deck, Carlos; Ferrada, Marcela; Alfaro, Mario; Perrone, Sergio
    Hemodynamic goals have been used in the past to guide therapy in patients with heart failure (HF). For HF patients whose signs and symptoms of congestion do not resolve with initial therapy it appears reasonable to consider hemodynamic monitoring at experienced sites. It has been suggested that implantable hemodynamic sensors may enable frequent monitoring of hemodynamic changes in HF patients and be used in tailoring vasodilator. We present the first human case of radio-frequency based, wireless pressure sensor for the monitoring of pulmonary artery pressure in patients with advanced HF. This sensor is delivered into the pulmonary artery via percutaneous venous access.
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    Bloqueio perioperatório do plexo lombar e isquemia cardíaca em pacientes com fratura de quadril: ensaio clínico randomizado
    (2018) Altermatt, Fernando; Echevarría, Ghislaine C.; Cuadra F., Juan Carlos de la; Baeza Vergara, Ricardo Gabriel; Ferrada, Marcela; De La Cuadra Fontaine, Juan Carlos; Corvetto Aqueveque, Marcia Antonia
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    Cambios en el pronóstico a largo plazo de la hipertensión arterial pulmonar
    (SOC MEDICA SANTIAGO, 2011) Enriquez, Andres; Castro, Pablo; Sepulveda, Pablo; Verdejo, Hugo; Greig, Douglas; Gabrielli, Luigi; Ferrada, Marcela; Lapostol, Carolina
    Background: Pulmonary artery hypertension (PAR) is a progressive disease with high mortality. Major advances had been made in the treatment of this condition during the last decade. Aim: To characterize the clinical evolution and mortality of a cohort of Chilean patients. Material and Methods: Seventeen patients with PAH diagnosed in the last 10 years in two Chilean hospitals were enrolled. Measurements at diagnosis included hemodynamic variables and 6-minute walk test. The patients were followed clinically for 3 years and the observed mortality was compared with that predicted by the prognostic equation proposed by the historic registry of the National Institutes of Health (NIH). Results: The mean age of patients was 45 years and 80% had an idiopathic PAH. The mean median pulmonary artery pressure was 57 +/- 15 mmHg, the cardiac index was 2.4 +/- 0.7 l/min/m(2) and the right atrial pressure was 12 +/- 8 mmHg. The 6-minute walk distance was 348 +/- 98 m. All patients received anticoagulants. Eighty two percent received ambrisentan, 12% received bosentan, 29% received iloprost and 24% sildenafil. At the end of follow-up only 3 patients had died, with an observed survival rate of 88, 82 and 82% at 1, 2 and 3 years, respectively. In contrast, the survival calculated according to the predictive formula of the NIH was 67, 56 and 45%, respectively. Among surviving patients, an improvement in exercise capacity was observed after one year (p < 0.05). Conclusions: The observed survival rate was significantly better than that estimated according to historical data. Furthermore, therapy was associated with an improvement in functional capacity after one year. This prognostic improvement is consistent with data of other contemporary registries published after the NIH Registry. (Rev Med Chile 2011; 139: 327-333).
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    Factores determinantes en la aparición de fibrilación auricular post-cirugía de revascularización miocárdica. Un estudio prospectivo
    (2007) Baeza Vergara, Ricardo Gabriel; Garayar Pulgar, Bernardita; Morán Velásquez, Sergio; Zalaquett Sepúlveda, Ricardo; Irarrázaval Llona, Manuel José; Becker Rencoret, Pedro Antonio; Viviani García, Paola; Ferrada, Marcela; Corbalán Herreros, Ramón
    Background: Atrial fibrillation (AF) is a relevant complication after coronary artery bypass grafting (CABG). However there is controversy regarding possible contributing factors. Aim: To study the incidence of AF, its risk factors and its repercussion on hospital stay and charges, in patients undergoing CABG. Material and methods: We prospectively collected information from all patients undergoing CABG in our institution, including demographic, surgical and laboratory variables. Exclusion criteria were chronic AF, recent onset AF and patients who needed additional surgical procedures. The primary endpoint was the incidence of AF during the hospital stay. Secondary endpoints were hospital length of stay and hospital charges. Results: We included 250 patients aged 62±9 years (199 males) in the analysis. Incidence of AF was 22% (54 patients). Multivariable analysis showed that age (Odds Ratio (OR) =1.10), previous CABG (OR =9.39), previous use of ACE inhibitors (OR =3.28) and aortic clamp >57 minutes (OR =3.97) were significantly associated with an increased risk of postoperative AF. Previous use of beta-blockers was associated with risk reduction (OR =0.43). Patients who developed AF had a longer hospital stay (p <0.001) and higher hospital charges (p =0.003). Conclusion: AF is a frequent complication in patients undergoing CABG. Risk factors are age, time of aortic clamp, previous CABG and ACE inhibitors. Beta-blockers may prevent its occurrence. Furthermore, AF has a negative impact on both hospital stay and hospital charges
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    Radiofrequency based wireless pressure sensor is a reliable method for hemodynamic assessment in ambulatory chronic heart failure patients: Comparison to swan-ganz catheter and echocardiography.
    (ELSEVIER SCIENCE INC, 2007) Castro, Pablo; Verdejo, Hugo; Bourge, Robert; Concepcion, Roberto; Ferrada, Marcela; Martinez, Alejandro; Alcaino, Milton; Alfaro, Mario; Godoy, Ivan; Perrone, Sergio