Browsing by Author "Fernández, Rodrigo"

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    Factor de crecimiento análogo a insulina-1 y cardiotrofina-1 inducido por ejercicio y su relación con hipertrofia miocárdica en maratonistas
    (2023) Chiong, Mario; Contreras Briceño, Felipe; Fernández, Rodrigo; Llevaneras, Silvana; Salinas, Manuel; Herrera, Sebastian; Saavedra, Rodrigo; Gabrielli, Luigi
    Antecedentes: El ejercicio de alta intensidad induce hipertrofia miocárdica necesaria para adaptar al corazón a la mayor demanda de trabajo. Se desconoce si correr una maratón induce de forma aguda factores humorales asociados al desarrollo de hipertrofia miocárdica en atletas. Objetivo: Evaluar cardiotrofina-1 (CT1) y el factor de crecimiento análogo a insulina-1 (IGF-1), conocidos inductores de hipertrofia, en maratonistas previo y justo después de correr una maratón y su relación con hipertrofia cardíaca. Métodos: Estudio prospectivo ciego simple de atletas hombres que corrieron la maratón de Santiago. Se incluyó un grupo control sedentario. En todos los sujetos se realizó un ecocardiograma transtorácico estándar. Los niveles de CT1 e IGF-1 se determinaron en plasma obtenidos antes (basal) y justo después de haber terminado (antes de 15 minutos) la maratón, usando test de ELISA. Resultados: Los atletas tenían frecuencias cardíacas menores que los controles, asociado con una mayor hipertrofia miocárdica, determinado por el grosor del septo y pared posterior del corazón, y volúmenes del ventrículo y aurícula izquierda. Los niveles basales de CT1 e IGF-1 fueron similares entre atletas y controles sedentarios. El correr la maratón aumentó los niveles de estas dos hormonas en un subgrupo de atletas. Solo los atletas que incrementaron los niveles de IGF-1, pero no de CT1, tenían volúmenes de ventrículo izquierdo y derecho más grandes que los otros atletas. Conclusiones: IGF-1 que se incrementa de forma aguda por el ejercicio, pero no CT1, estaría asociado con el aumento de los volúmenes ventriculares observado en los atletas.
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    Increased active phase atrial contraction is related to marathon runner performance
    (2018) Gabrielli, Luigi; Herrera, Sebastián; Contreras Briceño, Felipe; Vega, Julián; Ocaranza, María Paz; Yáñez Díaz, Fernando; Fernández, Rodrigo; Saavedra Madariaga, Rodrigo Alejandro; Sitges, Marta; García, Lorena; Chiong, Mario; Lavandero, Sergio; Castro Gálvez, Pablo Federico
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    Left cardiac remodelling assessed by echocardiography is associated with rho-kinase activation in long-distance runners
    (Wiley, 2021) Contreras Briceño, Felipe; Vega, Julián; Mandiola, Jorge; Ocaranza, María Paz; Herrera, Sebastián; Salinas, Manuel; Fernández, Rodrigo; Jalil, Jorge E.; Lavandero, Sergio; Chiong, Mario; Godoy, Paz; Castro, Pablo F.; Sitges, Marta; Gabrielli, Luigi
    This single-blind and cross-sectional study evaluated the role of Rho-kinase (ROCK) as a biomarker of the cardiovascular remodelling process assessed by echocardiography in competitive long-distance runners (LDRs) during the training period before a marathon race. Thirty-six healthy male LDRs (37.0 ± 5.3 years; 174.0 ± 7.0 height; BMI: 23.8 ± 2.8;.V O2-peak: 56.5 ± 7.3 mL·kg−1·min−1) were separated into two groups according to previous training level: high-training (HT, n = 16) ≥ 100 km·week−1 and low-training (LT, n = 20) ≥ 70 and < 100 km·week−1. Also, twenty-one healthy nonactive subjects were included as a control group (CTR). A transthoracic echocardiography was performed and ROCK activity levels in circulating leukocytes were measured at rest (48 h without exercising) the week before the race. The HT group showed a higher left ventricular mass index (LVMi) and left atrial volume index (LAVi) than other groups (p < 0.05, for both); also, higher levels of ROCK activity were found in LDRs (HT = 6.17 ± 1.41 vs. CTR = 1.64 ± 0.66 (p < 0.01); vs. LT = 2.74 ± 0.84; (p < 0.05)). In LDRs a direct correlation between ROCK activity levels and LVMi (r = 0.83; p < 0.001), and LAVi (r = 0.70; p < 0.001) were found. In conclusion, in male competitive long-distance runners, the load of exercise implicated in marathon training is associated with ROCK activity levels and the left cardiac remodelling process assessed by echocardiography.
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    Potential adverse cardiac remodelling in highly trained athletes : still unknown clinical significance
    (2018) Gabrielli, Luigi; Sitges, Marta; Chiong, Mario; Jalil Milad, Jorge; Ocaranza, María Paz; Llevaneras, Silvana; Herrera, Sebastián; Fernández, Rodrigo; Saavedra Madariaga, Rodrigo Alejandro; Yáñez Díaz, Fernando; Vergara, Luis; Díaz, Alexis; Lavandero, Sergio; Castro Gálvez, Pablo Federico
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    Riots and subways, a relationship moderated by the neighborhood's income level
    (2022) Cartes, Carlos; Asahi Kodama, Kenzo Javier; Fernández, Rodrigo; CEDEUS (Chile)
    Social disturbances due to socioeconomic and political factors received media attention during 2019 in places like France, Hong Kong, Chile, Nigeria, Sudan, Haiti, and Lebanon. In October 2019, Chile saw massive demonstrations in the capital city of Santiago. The cost of damage to infrastructure during the first month of unrest was estimated at US$ 4.6 billion, and the cost to the Chilean economy was about US$ 3 billion, 1.1% of its Gross Domestic Product. This study analyzes how the topology of the public transport network affected the locations of the 2019 riots in Santiago. On average, we find a clear association between proximity to the subway network and riot density. This association is significant only in neighborhoods with residents in the highest and lowest income quartiles. As a result, when analyzing social unrest and the critical role of public transport, policymakers should also consider the crucial role of income.