Browsing by Author "Fadic Ruiz, Ricardo Julio Nicolás"
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- ItemAndrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis(2014) Cabrera, D.; Gutiérrez, J.; Cabello Verrugio, Claudio Alejandro; Morales, M. G.; Mezzano, S.; Fadic Ruiz, Ricardo Julio Nicolás; Casar Leturia, Juan Carlos; Hancke, J. L.; Brandan, EnriqueBackground: Duchenne muscular dystrophy (DMD) is characterized by the absence of the cytoskeletal protein dystrophin, muscle wasting, increased transforming growth factor type beta (TGF-β) signaling, and fibrosis. At the present time, the only clinically validated treatments for DMD are glucocorticoids. These drugs prolong muscle strength and ambulation of patients for a short term only and have severe adverse effects. Andrographolide, a bicyclic diterpenoid lactone, has traditionally been used for the treatment of colds, fever, laryngitis, and other infections with no or minimal side effects. We determined whether andrographolide treatment of mdx mice, an animal model for DMD, affects muscle damage, physiology, fibrosis, and efficiency of cell therapy.Methods: mdx mice were treated with andrographolide for three months and skeletal muscle histology, creatine kinase activity, and permeability of muscle fibers were evaluated. Fibrosis and TGF-β signaling were evaluated by indirect immunofluorescence and Western blot analyses. Muscle strength was determined in isolated skeletal muscles and by a running test. Efficiency of cell therapy was determined by grafting isolated skeletal muscle satellite cells onto the tibialis anterior of mdx mice.Results: mdx mice treated with andrographolide exhibited less severe muscular dystrophy than untreated dystrophic mice. They performed better in an exercise endurance test and had improved muscle strength in isolated muscles, reduced skeletal muscle impairment, diminished fibrosis and a significant reduction in TGF-β signaling. Moreover, andrographolide treatment of mdx mice improved grafting efficiency upon intramuscular injection of dystrophin-positive satellite cells.Conclusions: These results suggest that andrographolide could be used to improve quality of life in individuals with DMD.
- ItemChanges in anxiety and depression symptoms associated to the outcome of MOH: A post-hoc analysis of the Comoestas Project(2018) Bottiroli, Sara; Allena, Marta; Sances, Grazia; De Icco, Roberto; Avenali, Micol; Fadic Ruiz, Ricardo Julio Nicolás; Katsarava, Zaza; Lainez, Miguel J. A.; Teresa Goicochea, Maria; Hojland Jensen, Rigmor; Nappi, Giuseppe; Tassorelli, Cristina
- ItemClinical and Demographical Characteristics of Patients with Medication Overuse Headache in Argentina and Chile: Analysis of the Latin American Section of COMOESTAS Project(2015) Shand, Beatriz; Goicochea, M. T.; Valenzuela, R.; Fadic Ruiz, Ricardo Julio Nicolás; Jensen, R.; Tassorelli, C.; Nappi, G.
- ItemClinical Subtypes of Medication Overuse Headache - Findings From a Large Cohort(2019) Viana, Michele; De Icco, Roberto; Allena, Marta; Sances, Grazia; Hojland, Jensen Rigmor; Katsarava, Zaza; Láinez, Miguel J. A.; Fadic Ruiz, Ricardo Julio Nicolás; Goicochea, María Teresa; Nappi, Giuseppe; Tassorelli, Cristina; et. al.
- ItemDisability, anxiety and depression associated with medication-overuse headache can be considerably reduced by detoxification and prophylactic treatment. Results from a multicentre, multinational study (COMOESTAS project)(2014) Bendtsen, L.; Munksgaard, S.; Tassorelli, C.; Nappi, G.; Katsarava, Z.; Lainez, M.; Leston, J.; Fadic Ruiz, Ricardo Julio Nicolás
- ItemHeteroplasmia de la mutación del ADN mitocondrial m.3243A>G en la diabetes y sordera de herencia materna(2013) Cataldo Bascuñan, Luis Rodrigo; Olmos Coelho, Pablo Roberto; Smalley Meylan, Susan Valerie; Díez, Alberto; Parada Daza, Alejandra; Gejman Enríquez, Roger; Fadic Ruiz, Ricardo Julio Nicolás; Santos Martín, José Luis
- ItemInclusion Body Myositis: A View from the Caenorhabditis elegans Muscle(2008) Rebolledo López, Daniela Victoria.; Nogueras de Minniti, Alicia Susana; Fadic Ruiz, Ricardo Julio Nicolás; Inestrosa Cantín, Nibaldo
- ItemIncrease in decorin and biglycan in Duchenne Muscular Dystrophy: role of fibroblasts as cell source of these proteoglycans in the disease(2006) Fadic Ruiz, Ricardo Julio Nicolás; Brandan, Enrique
- ItemIntracellular amyloid formation in muscle cells of A beta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification(2009) Nogueras de Minniti, Alicia Susana; Fadic Ruiz, Ricardo Julio Nicolás; Aldunate Magalhaes, Rebeca; Inestrosa Cantín, Nibaldo
- ItemMedication overuse headache in Europe and Latin America: general demographic and clinical characteristics, referral pathways and national distribution of painkillers in a descriptive, multinational, multicenter study(2016) Find, N. L.; Terlizzi, R.; Munksgaard, S. B.; Bendtsen, L.; Tassorelli, C.; Nappi, G.; Katsarava, Z.; Lainez, M.; Goicochea, M. T.; Shand, Beatriz; Fadic Ruiz, Ricardo Julio Nicolás; Spadafora, S.; Pagani, M.; Jensen, R.
- ItemPsychological, clinical, and therapeutic predictors of the outcome of detoxification in a large clinical population of medication-overuse headache : A six-month follow-up of the COMOESTAS Project(2019) Bottiroli, Sara; Allena, Marta; Sances, Grazia; De Icco, Roberto; Avenali, Micol; Fadic Ruiz, Ricardo Julio Nicolás; Katsarava, Zaza; Lainez, Miguel JA; Goicochea, Maria Teresa; Bendtsen, Lars; Jensen, Rigmor Højland; Nappi, Giuseppe; Tassorelli, Cristina
- ItemPure autonomic failure with cold induced sweating(2013) Idiaquez, J.; Fadic Ruiz, Ricardo Julio Nicolás; Verdugo, R.; Idiaquez Juan Francisco; Iodice, V.; Low, D.; Mathias, C.; Lombardi, R.; Lauria, G.
- ItemSkeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation(2008) Vial, C.; Fadic Ruiz, Ricardo Julio Nicolás; Brandan, Enrique
- ItemThe added value of an electronic monitoring and alerting system in the management of medication-overuse headache: A controlled multicentre study(2017) Tassorelli, Cristina; Jensen, Rigmor; Allena, Marta; De Icco, Roberto; Katsarava, Zaza; Lainez, J. Miguel; Leston, Jorge A.; Fadic Ruiz, Ricardo Julio Nicolás; Spadafora, Santiago; Pagani, Marco; Shand, Beatriz
- ItemThermal Effects on Ventilation in Cats. Participation of Carotid Body Chemoreceptors(1991) Fadic Ruiz, Ricardo Julio Nicolás; Zapata, Patricio
- ItemThermal Effects Upon the Chemosensory Drive of Ventilation(1993) Zapata, Patricio; Fadic Ruiz, Ricardo Julio Nicolás
- ItemVentilación mecánica no invasiva en pacientes con enfermedades neuromusculares y en pacientes con alteraciones de la caja torácica(2003) Lisboa Basualto, Carmen; Díaz Patino, Orlando; Fadic Ruiz, Ricardo Julio Nicolás