Browsing by Author "Espinosa, Javier"

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    A nomogram for predicting complications in patients with solid tumours and seemingly stable febrile neutropenia
    (2016) Jimenez Fonseca, Paula; Carmona-Bayonas, Alberto; Matos Garcia, Ignacio; Marcos, Rosana; Castanon, Eduardo; Antonio, Maite; Font, Carme; Biosca, Merce; Blasco, Ana; Lozano, Rebeca; Ramchandani, Avinash; Beato, Carmen; Martinez de Castro, Eva; Espinosa, Javier; Martinez-Garcia, Jeronimo; Ghanem, Ismael; Hernando Cubero, Jorge; Aragon Manrique, Isabel; Garcia Navalon, Francisco; Sevillano, Elena; Manzano, Aranzazu; Virizuela, Juan; Garrido, Marcelo; Mondejar, Rebeca; Angeles Arcusa, Maria; Bonilla, Yaiza; Perez, Quionia; Gallardo, Elena; del Carmen Soriano, Maria; Cardona, Merce; Sanchez Lasheras, Fernando; Jesus Cruz, Juan; Ayala, Francisco
    Background: We sought to develop and externally validate a nomogram and web-based calculator to individually predict the development of serious complications in seemingly stable adult patients with solid tumours and episodes of febrile neutropenia (FN).
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    A nomogram for predicting serious complications in patients with solid tumors and apparently stable febrile neutropenia: prospective data on 781 consecutive episodes from the FINITE study
    (2014) Ghanem, Ismael; Rebollo, Maite Antonio; Garrido, Marcelo; Martínez, Jerónimo; Font, Carme; Ramchandani, Avinash; Biosca, Merce; Beato, Carmen; Martínez de Castro, Eva; Castanon, Eduardo; Virizuela Echaburu, Juan; Espinosa, Javier; Sevillano, Elena; Aragon Manrique, Isabel; Cardona, Merce; Mondejar, Rebeca; Baron, Francisco; Acevedo Claros, Francisco Nicolás; Jiménez-Fonseca, Paula; Carmona Bayonas, Alberto
    Background: An accurate estimate of the likelihood of serious complications in patients with otherwise apparently stable febrile neutropenia (FN) may assist in decision-making regarding individualized therapy. Our group has developed a prognostic score for predicting complications in patients with solid tumors and apparently stable episodes called CISNE (Clinical Index for Stable Febrile Neutropenia). The purpose of this study is to present a nomogram based on the previously mentioned index in a broader dataset of patients. Methods: FINITE is a prospective and multicenter study which aims to investigate prognostic factors and outcomes of FN episodes with clinical stability at first assessment, defined as events without acute organ dysfunction, vital signs abnormalities or major infections. We performed a nomogram based on the CISNE score which includes the following prognostic variables: ECOG PS≥2, chronic obstructive pulmonary disease, cardiovascular disease, mucositis NCI grade ≥2, monocytes <200/mm3 and stress-induced hyperglycemia. A calibration plot was used to analyze the accuracy of this multivariate nomogram. Results: From October 2012 to December 2013, 781 patients with apparently stable FN were recruited in 21 Spanish hospitals. The rate of infection-related complications and death was 15.6% (95% confidence interval [CI], 12.9-18.6%) and 1.7% (95% CI, 0.98%-3.01%). A nomogram was designed according to the CISNE score. The area under the ROC curve was 0.836 (95% CI, 0.808-0.861). The observed and predicted probabilities also matched closely. Conclusions: Our group has developed a user-friendly nomogram for predicting complications in patients with apparently stable FN. This nomogram may be particularly useful to prevent premature discharges of cancer patients starting inpatient management.
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    Diversity of volcanism and evidence of discrete eruption centres in the Miocene Andes of Central Chile
    (2023) Leiva, Camila; Browning, John; Marquardt, Carlos; Clunes, Matias; Villarroel, Matias; Espinosa, Javier; Meyer, Martin; Payacán, Italo; Mpodozis, Constantino
    The geology of the Farellones region in the Andean Cordillera of central Chile, comprise a thick sequence of volcanic and volcaniclastic Miocene rocks. The occurrence of discrete eruption centres within this sequence, whilst suggested, has been difficult to stablish, as in the modern volcanic systems of the SVZ to the southeast of the study area. Here we report, for the first time a previously uncharacterized composite (Cerro Colorado Volcano) associated to a series of intercalated lava flows and pyroclastic deposits of basaltic to rhyolitic composition of Miocene age. Eruptive sequences reach 1.7 km in vertical section, yet the lateral continuity of units is interrupted by a major faults, and gravity collapse deposits. We document a series of large pyroclastic block and ash flows, which are overlain by rhyolitic pyroclastic density currents, ash fall and crystal, lithic and vitric tuffs, all making up more than 300 m of the sequence. A further 300 m thick unit of spherulite-bearing rhyolitic lavas represent the upper most section of the Cerro Colorado volcano. During the early stages of its construction magmas and hydrothermal fluids interacted to form a maar-diatreme system (Quebrada Lunes maar-diatreme). Much of the volcanic units are intruded by E-W and NW-SE striking andesitic and rhyolitic dikes One of the dikes exhibits internal pyroclastic textures evidence of shallow conduit fragmentation. This pyroclastic dike is further evidence of magma-fluid interaction and related explosivity. Similar pyroclastic breccias described elsewhere related to porphyry copper mineralization. Our results indicate that Miocene volcanism in the Andes of Central Chile is linked to discrete eruptive centres which can be identified and characterized through careful field mapping.