Browsing by Author "Durán, Josefina"

Now showing 1 - 12 of 12
  • Thumbnail Image
    Item
    Asociación entre los componentes de sarcopenia y sintomatología de fibromialgia en sujetos de la cohorte poblacional de Maule (Mauco)
    (2022) Tumani Karmy, María Fernanda; Parada Daza, Alejandra; Durán, Josefina; Pontificia Universidad Católica de Chile. Facultad de Medicina
    Introducción: el síndrome de fibromialgia (FM) se caracteriza por presentar dolor crónico generalizado, en donde existe neuro-inflamación. La disminución de masa libre de grasa (MLG) se ha asociado a mayor presencia de marcadores inflamatorios, respectivamente. A la fecha, no se ha asociado la MLG ni fuerza muscular con intensidad de síntomas en estos sujetos con fibromialgia. Objetivo: evaluar la asociación entre los componentes de la sarcopenia y sintomatología en FM. Metodología: se analizaron los datos de una submuestra de la cohorte poblacional de Maule. Resultados: se observó una correlación inversa entre fuerza muscular e IMLG con síntomas en FM. Además se observó una asociación entre IMLG e Intensidad de dolor. Conclusión: existe una correlación entre los componentes de la sarcopenia e intensidad de síntomas en FM.
  • Thumbnail Image
    Item
    Chronic pain in Chile: first prevalence report of noncancer chronic pain, fibromyalgia, and neuropathic pain and its associated factors
    (2023) Durán, Josefina; Tejos Bravo, Macarena; Cid, Vicente; Ferreccio Readi, Catterina; Calvo Bascuñan, Margarita
    Although we know chronic pain (CP) affects approximately 30% of people in developed countries, data from Latin America are scarce. Moreover, prevalence of specific CP conditions, such as chronic noncancer pain (CNCP), fibromyalgia (FM), and neuropathic pain (NP), is unknown. To estimate them in Chile, we prospectively enrolled 1945 participants (61.4% women and 38.6% men), aged 38 to 74 years, from an agricultural town who answered a Pain Questionnaire, the Fibromyalgia Survey Questionnaire, and Douleur Neuropathique 4 (DN4) to identify CNCP, FM, and NP, respectively. The estimated prevalence of CNCP was 34.7% (95% CI 32.6; 36.8), with an average duration of 32.3 months (SD ± 56.3), producing deep impairments in daily activities, sleep, and mood. We estimated a prevalence of 3.3% for FM (95% CI 2.5; 4.1) and 12% for NP (95% CI 10.6; 13.4). Female sex, fewer school years, and depressive symptoms were associated with FM and NP, whereas diabetes was only associated with NP. We standardized the results from our sample against the whole Chilean population and found no significant difference to our crude estimates. This is in line with studies from developed countries, highlighting the idea that despite genetic and environmental differences, the conditions that confer risk to CNCP remain stable.
  • Thumbnail Image
    Item
    Clinical Presentation and Causes of Recurrent Corneal Erosion Syndrome : Review of 100 Patients
    (2014) Diez Feijoo, E; Grau Diez, Arturo Eduardo; Abusleme, Eugenia; Durán, Josefina
  • Thumbnail Image
    Item
    Elbow monoarthritis and bone infarction as a form of presentation of B cell lymphoma. Case report
    (2017) Díaz, P; Contreras Olea, Oscar; Durán, Josefina
  • Thumbnail Image
    Item
    Evaluation of the Health Assessment Questionnaire Disability Index in Chilean patients with rheumatoid arthritis
    (2019) Durán, Josefina; Dominguez de Landa, Maria Angelica; Espinoza Sepúlveda, Manuel Antonio
  • Thumbnail Image
    Item
    Inhibition of angiogenesis by platelets in systemic sclerosis patients
    (2015) Hirigoyen Pérez, Daniela María.; Burgos, Paula I.; Mezzano, Veronica.; Durán, Josefina; Barrientos, Magaly.; Sáez, Claudia G.; Panes Becerra, Olga Teresa; Mezzano, Diego; Iruretagoyena B., Mirentxu
    Abstract Introduction Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by microvascular damage, inflammation, and fibrosis. It has become increasingly evident that platelets, beyond regulating hemostasis, are important in inflammation and innate immunity. Platelets may be an important source of proinflammatory and profibrotic cytokines in the vascular microenvironment. In this study, we sought to assess the contribution of platelet-derived factors in patients with SSc to the angiogenesis of human dermal microvascular endothelial cells (DMVECs) in a tubule formation assay and to characterize the secretion of profibrotic and proinflammatory cytokines in these platelets. Methods We analyzed platelets obtained from 30 patients with SSc and 12 healthy control subjects. Angiogenesis was evaluated in vitro with a DMVEC tubule formation assay on Matrigel and platelet-derived angiogenic factors such as vascular endothelial growth factor (VEGF), 165b isoform (VEGF165b), and cytokine secretion was evaluated. Platelet serotonin content was also determined. Results When DMVECs were incubated with SSc platelet releasates, tubule formation was significantly inhibited (p < 0.01, t test), and higher expression of endothelin-1 in these cells was observed compared with control subjects (p < 0.05, Mann–Whitney U test). In SSc platelet releasates, VEGF165b was significantly higher (p < 0.05, t test), and the VEGF165b/VEGF ratio was increased compared with that of control subjects. Higher secretion of transforming growth factor β (p < 0.01, t test) and CD40L (p < 0.01, t test) was observed compared with control subjects. Also, intraplatelet serotonin levels were lower in platelets obtained from patients with diffuse SSc compared with patients with limited SSc and control subjects (p < 0.05, t test). Conclusions Our findings suggest that antiangiogenic factors such as VEGF165b, together with proinflammatory and profibrotic factors secreted by platelets, can contribute to the progression of peripheral microvascular damage, defective vascular repair, and fibrosis in patients with SSc.Abstract Introduction Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by microvascular damage, inflammation, and fibrosis. It has become increasingly evident that platelets, beyond regulating hemostasis, are important in inflammation and innate immunity. Platelets may be an important source of proinflammatory and profibrotic cytokines in the vascular microenvironment. In this study, we sought to assess the contribution of platelet-derived factors in patients with SSc to the angiogenesis of human dermal microvascular endothelial cells (DMVECs) in a tubule formation assay and to characterize the secretion of profibrotic and proinflammatory cytokines in these platelets. Methods We analyzed platelets obtained from 30 patients with SSc and 12 healthy control subjects. Angiogenesis was evaluated in vitro with a DMVEC tubule formation assay on Matrigel and platelet-derived angiogenic factors such as vascular endothelial growth factor (VEGF), 165b isoform (VEGF165b), and cytokine secretion was evaluated. Platelet serotonin content was also determined. Results When DMVECs were incubated with SSc platelet releasates, tubule formation was significantly inhibited (p < 0.01, t test), and higher expression of endothelin-1 in these cells was observed compared with control subjects (p < 0.05, Mann–Whitney U test). In SSc platelet releasates, VEGF165b was significantly higher (p < 0.05, t test), and the VEGF165b/VEGF ratio was increased compared with that of control subjects. Higher secretion of transforming growth factor β (p < 0.01, t test) and CD40L (p < 0.01, t test) was observed compared with control subjects. Also, intraplatelet serotonin levels were lower in platelets obtained from patients with diffuse SSc compared with patients with limited SSc and control subjects (p < 0.05, t test). Conclusions Our findings suggest that antiangiogenic factors such as VEGF165b, together with proinflammatory and profibrotic factors secreted by platelets, can contribute to the progression of peripheral microvascular damage, defective vascular repair, and fibrosis in patients with SSc.Abstract Introduction Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by microvascular damage, inflammation, and fibrosis. It has become increasingly evident that platelets, beyond regulating hemostasis, are important in inflammation and innate immunity. Platelets may be an important source of proinflammatory and profibrotic cytokines in the vascular microenvironment. In this study, we sought to assess the contribution of platelet-derived factors in patients with SSc to the angiogenesis of human dermal microvascular endothelial cells (DMVECs) in a tubule formation assay and to characterize the secretion of profibrotic and proinflammatory cytokines in these platelets. Methods We analyzed platelets obtained from 30 patients with SSc and 12 healthy control subjects. Angiogenesis was evaluated in vitro with a DMVEC tubule formation assay on Matrigel and platelet-derived angiogenic factors such as vascular endothelial growth factor (VEGF), 165b isoform (VEGF165b), and cytokine secretion was evaluated. Platelet serotonin content was also determined. Results When DMVECs were incubated with SSc platelet releasates, tubule formation was significantly inhibited (p < 0.01, t test), and higher expression of endothelin-1 in these cells was observed compared with control subjects (p < 0.05, Mann–Whitney U test). In SSc platelet releasates, VEGF165b was significantly higher (p < 0.05, t test), and the VEGF165b/VEGF ratio was increased compared with that of control subjects. Higher secretion of transforming growth factor β (p < 0.01, t test) and CD40L (p < 0.01, t test) was observed compared with control subjects. Also, intraplatelet serotonin levels were lower in platelets obtained from patients with diffuse SSc compared with patients with limited SSc and control subjects (p < 0.05, t test). Conclusions Our findings suggest that antiangiogenic factors such as VEGF165b, together with proinflammatory and profibrotic factors secreted by platelets, can contribute to the progression of peripheral microvascular damage, defective vascular repair, and fibrosis in patients with SSc.
  • Thumbnail Image
    Item
    Methotrexate dosage as a source of bias in biological trials in rheumatoid arthritis : a systematic review
    (2016) Durán, Josefina; Bockorny, M.; Dalal, D.; Lavalley, M.; Felson, D.
  • Thumbnail Image
    Item
  • Thumbnail Image
    Item
    The effect on treatment response of fibromyalgic symptoms in early rheumatoid arthritis patients : results from the ESPOIR cohort
    (2015) Durán, Josefina; Combe, Bernard; Niu, Jingbo; Rincheval, Nathalie; Gaujoux Viala, Cécile; Felson, David T.
  • Thumbnail Image
    Item
    The efficacy of adding group behavioral activation to usual care in patients with fibromyalgia and major depression : design and protocol for a randomized clinical trial
    (2018) Gómez Pérez, Lidia; Vergés, Álvaro; Vázquez Taboada, Ana Rocío; Durán, Josefina; González Tugas, Matías
  • Thumbnail Image
    Item
    The efficacy of adding group behavioral activation to usual care in patients with fibromyalgia and major depression : design and protocol for a randomized clinical trial.
    (2018) Gómez Pérez, Lidia; Vergés, Álvaro; Vázquez Taboada, Ana Rocío; Durán, Josefina; González Tugas, Matías
  • Thumbnail Image
    Item
    The prevalence of rheumatoid arthritis in Chile : a nationwide study performed as part of the national health survey
    (2020) Durán, Josefina; Massardo Vega, Loreto; Llanos Muñoz, Carolina; Iacobelli Gabrielli, Sergio Hernán; Burgos, Paula I.; Cisternas Martínez, Marcela Carolina; Iruretagoyena B., Mirentxu; Armstrong Bruzzone, Macarena; Aguilera Insunza, Raquel; Radrigán Araya, Francisco José Ricardo; Martínez Ruiz-Esquide, María Eugenia; Passi Solar, Alvaro Rodrigo; Vásquez Aravena, Nancy Margarita; Margozzini Maira, Paula; Riedemann, P.; Crisóstomo, N.; Cifuentes, C.; Hagedorn, L.; Cisternas, A.