Browsing by Author "Dukes, Nathan"
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- ItemIn vitro effects of benzimidazole/thioether-copper complexes with antitumor activity on human erythrocytes(2018) Suwalsky, Mario; Castillo, Ivan; Sánchez-Eguía, Brenda N.; Gallardo, María José; Dukes, Nathan; Santiago-Osorio, Edelmiro; Aguiñiga, Itzen; Rivera-Martínez, Ana R.
- ItemInteractions of the antiviral and antiparkinson agent amantadine with lipid membranes and human erythrocytes(ELSEVIER SCIENCE BV, 2015) Suwalsky, Mario; Jemiola Rzeminska, Malgorzata; Altamirano, Mariella; Villena, Fernando; Dukes, Nathan; Strzalka, KazimierzAimed to better understand the molecular mechanisms of its interactions with cell membranes, human erythrocyte and molecular models of the red cell membrane were utilized. The latter consisted of bilayers of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE), representative of phospholipid classes located in the outer and inner monolayers of the human erythrocyte membrane, respectively. The capacity of amantadine to perturb the bilayer structures of DMPC and DMPE was evaluated by X-ray diffraction, fluorescence spectroscopy and differential scanning calorimetry (DSC). In an attempt to further elucidate its effects on cell membranes, the present work also examined amantadine influence on the morphology of intact human erythrocytes by means of scanning electron microscopy (SEM). Results indicated that amantadine induced morphological changes to human erythrocytes and interacted in a concentration-dependent manner with DMPC bilayers in contrast to DMPE that was hardly affected by the presence of the drug. (C) 2015 Elsevier B.V. All rights reserved.
- ItemMorphological Effects Induced In Vitro by Propranolol on Human Erythrocytes(2015) Suwalsky, Mario; Zambrano, Pablo; Villena, Fernando; Manrique Moreno, Marcela; Gallardo, María José; Jemiola, Malgorzata; Strzalka, Kazimierz; EdwardsM., Ana M; Mennickent, Sigrid; Dukes, Nathan