Browsing by Author "Del Rio, Rodrigo"

Now showing 1 - 20 of 22
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    Ablation of brainstem C1 neurons improves cardiac function in volume overload heart failure
    (2019) Andrade Andrade, David Cristóbal; Toledo, Camilo; Díaz, Hugo S.; Lucero, Claudia; Arce Álvarez, Alexis; Oliveira, Luis M.; Takakura, Ana C.; Moreira, Thiago S.; Schultz, Harold D.; Del Rio, Rodrigo; Marcus, Noah J.; Alcayaga Urbina, Julio Andrés
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    Acute effects of high-intensity interval training session and endurance e8xercise on pulmonary function and cardiorespiratory coupling
    (2020) Andrade Andrade, David Cristóbal; Arce Álvarez, Alexis; Parada, Felipe; Uribe, Sebastián; Gordillo, Pamela; Dupré, Anita; Ojeda, Carla; Palumbo, Fiorella; Castro, Guillermo; Vásquez Muñoz, Manuel; Del Rio, Rodrigo; Ramírez Campillo, Rodrigo; Izquierdo, Mikel
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    Acute Effects of Systemic Erythropoietin Injections on Carotid Body Chemosensory Activity Following Hypoxic and Hypercapnic Stimulation
    (2018) Andrade Andrade, David Cristóbal; Iturriaga Agüera, Rodrigo; Jeton, Florine; Alcayaga Urbina, Julio Andrés; Voituron, Nicolas; Del Rio, Rodrigo
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    Arginase-endothelial nitric oxide synthase imbalance contributes to endothelial dysfunction during chronic intermittent hypoxia
    (2015) Krause Leyton, Bernardo; Del Rio, Rodrigo; Moya, Esteban A.; Marquez Gutiérrez, Mónica; Casanello Toledo, Paola Cecilia; Iturriaga Agüera, Rodrigo
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    Benefits of oxytocin administration in obstructive sleep apnea
    (2017) Jain, Vivek; Marbach, Joseph; Kimbro, Shawn; Andrade Andrade, David Cristóbal; Jain, Arad; Capozzi, Eleanor; Mele, Kyle; Del Rio, Rodrigo; Kay, Matthew W.; Mendelowitz, David
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    Carbamylated form of human erythropoietin normalizes cardiorespiratory disorders triggered by intermittent hypoxia mimicking sleep apnea syndrome
    (LIPPINCOTT WILLIAMS & WILKINS, 2021) Andrade, David C.; Toledo, Camilo; Diaz, Hugo S.; Pereyra, Katherin, V; Schwarz, Karla G.; Diaz Jara, Esteban; Melipillan, Claudia; Rios Gallardo, Angelica P.; Uribe Ojeda, Atenea; Alcayaga, Julio; Quintanilla, Rodrigo A.; Iturriaga, Rodrigo; Richalet, Jean Paul; Voituron, Nicolas; Del Rio, Rodrigo
    Background and objective: Chronic intermittent hypoxia (CIH), one of the main features of obstructive sleep apnea (OSA), enhances carotid body-mediated chemoreflex and induces hypertension and breathing disorders. The carbamylated form of erythropoietin (cEpo) may have beneficial effects as it retains its antioxidant/anti-inflammatory and neuroprotective profile without increasing red blood cells number. However, no studies have evaluated the potential therapeutic effect of cEpo on CIH-related cardiorespiratory disorders. We aimed to determine whether cEpo normalized the CIH-enhanced carotid body ventilatory chemoreflex, the hypertension and ventilatory disorders in rats. Methods: Male Sprague-Dawley rats (250 g) were exposed to CIH (5% O-2, 12/h, 8 h/day) for 28 days. cEPO (20 mu g/kg, i.p) was administrated from day 21 every other day for one more week. Cardiovascular and respiratory function were assessed in freely moving animals. Results: Twenty-one days of CIH increased carotid body-mediated chemoreflex responses as evidenced by a significant increase in the hypoxic ventilatory response (FiO2 10%) and triggered irregular eupneic breathing, active expiration, and produced hypertension. cEpo treatment significantly reduced the carotid body--chemoreflex responses, normalizes breathing patterns and the hypertension in CIH. In addition, cEpo treatment effectively normalized carotid body chemosensory responses evoked by acute hypoxic stimulation in CIH rats. Conclusion: Present results strongly support beneficial cardiorespiratory therapeutic effects of cEpo during CIH exposure.
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    Carotid Body Inflammation: Role in Hypoxia and in the Anti-inflammatory Reflex
    (AMER PHYSIOLOGICAL SOC, 2022) Iturriaga, Rodrigo; Del Rio, Rodrigo; Alcayaga, Julio
    Emergent evidence indicates that the carotid body (CB) chemoreceptor may sense systemic inflammatory molecules and is an afferent arm of the anti-inflammatory reflex. Moreover, a proinflammatory milieu within the CB is involved in the enhanced CB chemosensory responsiveness to oxygen following sustained and intermittent hypoxia. In this review, we focus on the physiopathological participation of CBs in inflammatory diseases, such as sepsis and intermittent hypoxia.
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    Carotid Body Type-I Cells Under Chronic Sustained Hypoxia: Focus on Metabolism and Membrane Excitability
    (2018) Pulgar-Sepulveda, Raul; Varas, Rodrigo; Iturriaga Agüera, Rodrigo; Del Rio, Rodrigo; Ortiz, Fernando C.
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    Chronic phenytoin treatment reduces rat carotid body chemosensory responses to acute hypoxia
    (2016) Alcayaga Urbina, Julio Andrés; Oyarce, María Paz; Del Rio, Rodrigo
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    Designing and implementing a test for measuring critical thinking in primary school
    (2016) Gelerstein, Damián; Del Rio, Rodrigo; Nussbaum Voehl, Miguel; Chiuminatto, Pablo; Ximena, López
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    Effects of fertilization on radial growth of Pinus pinea explored hourly using dendrometers
    (2024) Loewe Muñoz, Veronica Francisca; Del Rio, Rodrigo; Delard Rodriguez, Claudia; Balzarini, Mónica
    Background: Stone pine (Pinus pinea), a drought-resistant species, has significant socio-economic benefits and increasing interest for the establishment of productive plantations in several countries, especially in a climate change context. Monitoring hourly stem diameter variations contributes to the understanding of the tree-growth response to changes in environmental conditions and management. By monitoring the diameter expansion of tree stems, high-resolution band dendrometers were used to study the development of adult trees growing in a semi-arid coastal environment of central Chile under fertilized and non-fertilized soil conditions through the span of a year. Results: Short cycles (< 21 h) were few in fertilized and non-fertilized trees (6 and 4, respectively), whereas long cycles (> 28 h) occurred at a higher frequency in fertilized trees (16 vs 6). Most of the circadian cycles were regular (24 ± 3 h). The longest cycle duration (59 h) was observed in fertilized trees during spring. In all seasons, each phase of the circadian cycle, especially during the stem diameter increment phase (P3, irreversible growth), started earlier in fertilized than in control trees. P3 duration was significantly longer in fertilized than in control trees in springtime. The maximum shrinkage (P1) was observed in summer for both treatments. Stem diameter increased faster in fertilized than in control trees throughout the year, with the highest accumulation occurring in spring and the lowest in autumn. The daily variability pattern showed lower growth under high temperature across seasons. Conclusions: This study highlights the importance of fertilization in enhancing stone pine diameter growth. This cultural practice should be further explored to contribute to the mitigation of climate change effects in semi-arid environments.
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    Exercise training improves cardiac autonomic control, cardiac function, and arrhythmogenesis in rats with preserved-ejection fraction heart failure
    (2017) Andrade Andrade, David Cristóbal; Arce-Alvarez Alexis; Toledo, Camilo; Díaz, Hugo S.; Lucero, Claudia; Schultz, Harold D.; Marcus, Noah J.; Del Rio, Rodrigo
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    Integrating a collaboration script and group awareness to support group regulation and emotions towards collaborative problem solving
    (Taylor and Francis, 2022) Rojas, Matias; Nussbaum, Miguel; Guerrero, Orlando; Chiuminatto Munoz Pablo Andres; Greiff, Samuel; Del Rio, Rodrigo; Alvares, Danilo
    The research landscape displays increasing awareness of the important role of self-regulation and emotions in the process of acquiring Collaborative Problem-Solving skills (CPS), which are considered essential in almost all areas of life. However, there is still a dearth of research on developing CPS skills among elementary-school students. Our research therefore looks at how elementary school students' regulation skills and emotions are supported by a collaborative game using a collaboration script to scaffold group awareness. An intervention was carried out with a sample of 223 students aged between 10 and 13. The experimental group worked collaboratively in sub-groups, scaffolded by the game, while the control group attended regular lessons. The students' attitudes towards collaboration were evaluated before and after the intervention. In addition to this, a focus group was held a week after the intervention, which involved 32 students from both groups. The quantitative analysis revealed that attitudes towards collaboration improved significantly among students in the experimental group. This difference can be explained by a combination of the intervention, the students' initial attitudes, and their respective GPAs. The qualitative analysis provided evidence of the regulation processes and emotions that emerge when combining a collaboration script with group awareness tools during CPS activities. Furthermore, the results highlighted the relationship between these tools and positive emotions (i.e., satisfaction), co-regulation, and shared regulation. These findings suggest that there is a relationship between the co-regulation process required by the game and a shift in emotions from frustration to satisfaction. This work provides evidence of how scaffolding group awareness using a collaboration script supports regulation skills and emotions, thus promoting the development of Collaborative Problem-Solving skills.
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    Intermittent Hypoxia-Induced Carotid body chemosensory potentiation and hypertension are critically dependent on peroxynitrite formation
    (2016) Moya, E.; Arias, P.; Varela, C.; Oyarce, María Paz; Del Rio, Rodrigo; Iturriaga Agüera, Rodrigo
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    MODIFICATION OF BORON DOPED DIAMOND ELECTRODES WITH GLUCOSE OXIDASE, CHARACTERIZATION BY ELECTROCHEMICAL TECHNIQUES
    (SOC CHILENA QUIMICA, 2011) Del Rio, Rodrigo; Armijo, Francisco; Schrebler, Ricardo; Del Canto, Gabriela; Vergara, Claudia; Gutierrez, Cesar
    In this work, we report the effect of the direct successive modifications with Glucose oxidase onto boron doped diamond electrode (BDD). The modification due to the enzyme adsorption, on the potentiodynamic response of the electrode, was evaluated using Fe(CN)(6)(4-/3-) red-ox couple on the electrolyte and the Delta Ep variations were related with the number of modifications. Contact angle measurements and the electrochemical impedance spectra were also used to characterized the modifications and they showed variations in the same way that the potentiodynamic data.
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    Modification of composites of block copolymers-gold nanoparticles with enzymes and their characterization by electrochemical techniques
    (SPRINGER, 2011) Del Rio, Rodrigo; Armijo, Francisco; Schrebler, Ricardo; Gutierrez, Cesar; Amaro, Andrea; Biaggio, Sonia R.
    In this work, the poly(styrene-vynil pyridine) block copolymer was used as a porous pattern to study the electrodeposition of gold inside the pores, as a new method to obtain gold nanoparticles. The porous pattern left by the copolymer film onto a conductive glass surface was characterized by atomic force microscopy (AFM), evidencing pores of 30 nm diameter. After the electrodeposition, 30 nm diameter gold nanoparticles were obtained and they were characterized by cyclic voltammetry (CV) and AFM, and then used to study the adsorption of glucose oxidase enzyme. The adsorption process of glucose oxidase on gold nanowires was investigated by CV and electrochemical impedance spectroscopy. The morphological and capacitance results indicate that the block copolymer-gold nanoparticle composite seems to be a good candidate to design biosensors and immunosensors.
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    Oxidative stress augments chemoreflex sensitivity in rats exposed to chronic intermittent hypoxia
    (2016) Morgan, B. J.; Bates, M. L.; Del Rio, Rodrigo; Wang, Z.; Dopp, J. M.
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    Poly-o-aminophenol obtained at high potentials by cyclic voltammetry on SnO2 : F electrodes. application in quantitative determination of ascorbic acid
    (2009) Armijo Mancilla, Juan Francisco; Canales, Luis I.; Del Rio, Rodrigo; Valle de la Cortina, María Angélica del
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    Polymers Nucleation and Growth Mechanism : Solubility, a Determining Factor
    (2012) Romero, Mario Alberto; Valle de la Cortina, María Angélica del; Del Rio, Rodrigo; Díaz Alzamora, Fernando Raúl; Armijo Mancilla, Juan Francisco