Browsing by Author "De Backer, D."

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    Can venous-to-arterial carbon dioxide differences reflect microcirculatory alterations in patients with septic shock?
    (2016) Arango Dávila, C.; De Backer, D.; Ospina Tascón, G.; Umaña, M.; Bermúdez, W.; Bautista Rincón, D.; Valencia, J.; Madriñán, H.; Hernández P., Glenn; Bruhn, Alejandro
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    Microcirculatory alterations are associated with pulmonary dead-space fraction in moderate and severe ards
    (2015) Ospina-Tascón, G. A.; Bruhn, Alejandro; Hernández P., Glenn; Bautista-Rincón, D. F.; Madriñán, H. J.; Valencia, J. D.; Bermúdez, W. F.; Salas, C. E.; De Backer, D.
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    Microcirculatory dysfunction and dead-space ventilation in early ARDS: a hypothesis-generating observational study.
    (2020) Ospina-Tascón, G. A.; Hernández P., Glenn; Bruhn, Alejandro; Bautista Rincón, Diego F.; Madriñán, H. J.; Valencia, J. D.; Bermúdez, W. F.; Quiñones, Edgardo; Calderón-Tapia, Luis E.; De Backer, D.
    Abstract Background Ventilation/perfusion inequalities impair gas exchange in acute respiratory distress syndrome (ARDS). Although increased dead-space ventilation (VD/VT) has been described in ARDS, its mechanism is not clearly understood. We sought to evaluate the relationships between dynamic variations in VD/VT and extra-pulmonary microcirculatory blood flow detected at sublingual mucosa hypothesizing that an altered microcirculation, which is a generalized phenomenon during severe inflammatory conditions, could influence ventilation/perfusion mismatching manifested by increases in VD/VT fraction during early stages of ARDS. Methods Forty-two consecutive patients with early moderate and severe ARDS were included. PEEP was set targeting the best respiratory-system compliance after a PEEP-decremental recruitment maneuver. After 60 min of stabilization, hemodynamics and respiratory mechanics were recorded and blood gases collected. VD/VT was calculated from the CO2 production ($$V_{{{\text{CO}}_{2} }}$$VCO2) and CO2 exhaled fraction ($$F_{{{\text{ECO}}_{2} }}$$FECO2) measurements by volumetric capnography. Sublingual microcirculatory images were simultaneously acquired using a sidestream dark-field device for an ulterior blinded semi-quantitative analysis. All measurements were repeated 24 h after. Results Percentage of small vessels perfused (PPV) and microcirculatory flow index (MFI) were inverse and significantly related to VD/VT at baseline (Spearman’s rho = − 0.76 and − 0.63, p < 0.001; R2 = 0.63, and 0.48, p < 0.001, respectively) and 24 h after (Spearman’s rho = − 0.71, and − 0.65; p < 0.001; R2 = 0.66 and 0.60, p < 0.001, respectively). Other respiratory, macro-hemodynamic and oxygenation parameters did not correlate with VD/VT. Variations in PPV between baseline and 24 h were inverse and significantly related to simultaneous changes in VD/VT (Spearman’s rho = − 0.66, p < 0.001; R2 = 0.67, p < 0.001). Conclusion Increased heterogeneity of microcirculatory blood flow evaluated at sublingual mucosa seems to be related to increases in VD/VT, while respiratory mechanics and oxygenation parameters do not. Whether there is a cause–effect relationship between microcirculatory dysfunction and dead-space ventilation in ARDS should be addressed in future research.
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    Relationship between microcirculatory alterations and venous-to-arterial carbon dioxide differences in patients with septic shock
    (2014) Ospina Tascón, Gustavo A.; Bautista, D. F.; Umaña, M.; Bermúdez, W. F.; Valencia, J. D.; Madriñan, H. J.; Bruhn, Alejandro; Hernández P., Glenn; Granados, M.; Arango-Dávila, C. A.; De Backer, D.