Browsing by Author "Díaz Patiño, Orlando"
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- ItemAccuracy of sleep questionnaires for obstructive sleep apnea syndrome screening(2018) Díaz Patiño, Orlando
- ItemBehavior of Quality of Life (SGRQ) in COPD Patients According to BODE Scores. Comportamiento de la calidad de vida (SGRQ) en pacientes con EPOC según las puntuaciones BODE(2015) Nonato, Nívia L.; Díaz Patiño, Orlando; Nascimento, Oliver A.; Dreyse, Jorge; Jardim, José R.; Lisboa Basualto, Carmen
- ItemComportamiento de la calidad de vida (SGRQ) en pacientes con EPOC según las puntuaciones BODE(2015) Nonato, Nívia L.; Díaz Patiño, Orlando; Nascimento, Oliver A.; Dreyse, Jorge; Jardim, José R.; Lisboa Basualto, Carmen
- ItemDeteccion precoz de cancer pulmonar con tomografía computarizada de torax en pacientes con enfermedad pulmonar obstructiva cronica tabaquica(2016) Saldías Peñafiel, Fernando; Díaz, J.; Rain, M.; Illanes, C.; Díaz, T.; Díaz Patiño, Orlando
- ItemDificultades en la elección de una ecuación de referencia para la interpretación de los resultados de capacidad de difusión de monóxido de carbono(2013) Briceño Villafane, Catalina Paz; Dreyse, Jorge; Mendoza L., Laura; Díaz Patiño, Orlando; Mercado M., Gesma; Borzone, Gisella
- ItemDo frequent moderate exacerbations contribute to progression of chronic obstructive pulmonary disease in patients who are ex-smokers?(2015) Dreyse, Jorge; Díaz Patiño, Orlando; Repetto Lisboa, Paula Beatriz; Morales, Arturo; Saldías Peñafiel, Fernando; Lisboa Basualto, Carmen; Dreyse, Jorge; Díaz Patiño, Orlando; Repetto Lisboa, Paula Beatriz; Morales, Arturo; Saldías Peñafiel, Fernando; Lisboa Basualto, Carmen
- ItemEfects of eccentric, concentric and eccentric/concentric training on muscle function and mass, functional performance, cardiometabolic health, quality of life and molecular adaptations of skeletal muscle in COPD patients: a multicentre randomised trial(2022) Peñailillo, Luis; Valladares-Ide, Denisse; Jannas-Velas, Sebastián; Flores-Opazo, Marcelo; Jalón, Mauricio; Mendoza, Laura; Nuñez, Ingrid; Díaz Patiño, OrlandoBackground: Chronic obstructive pulmonary disease (COPD) is the third cause of death worldwide. COPD is char‑acterised by dyspnoea, limited exercise tolerance, and muscle dysfunction. Muscle dysfunction has been linked to dysregulation between muscle protein synthesis, myogenesis and degradation mechanisms. Conventional concentric cycling has been shown to improve several clinical outcomes and reduce muscle wasting in COPD patients. Eccentric cycling is a less explored exercise modality that allows higher training workloads imposing lower cardio-metabolic demand during exercise, which has shown to induce greater muscle mass and strength gains after training. Interestingly, the combination of eccentric and concentric cycling training has scarcely been explored. The molecular adaptations of skeletal muscle after exercise interventions in COPD have shown equivocal results. The mechanisms of muscle wasting in COPD and whether it can be reversed by exercise training are unclear. Therefore, this study aims two-fold: (1) to compare the efects of 12 weeks of eccentric (ECC), concentric (CONC), and combined eccentric/concentric (ECC/CONC) cycling training on muscle mass and function, cardiometabolic health, physical activity levels and quality of life in severe COPD patients; and (2) to examine the molecular adaptations regulating muscle growth after training, and whether they occur similarly in specifc muscle fbres (i.e., I, IIa and IIx). Methods: Study 1 will compare the efects of 12 weeks of CONC, ECC, versus ECC/CONC training on muscle mass and function, cardiometabolic health, levels of physical activity and quality of life of severe COPD patients using a multicentre randomised trial. Study 2 will investigate the efects of these training modalities on the molecular adaptations regulating muscle protein synthesis, myogenesis and muscle degradation in a subgroup of patients from Study 1. Changes in muscle fbres morphology, protein content, genes, and microRNA expression involved in skeletal muscle growth will be analysed in specifc fbre-type pools. Discussion: We aim to demonstrate that a combination of eccentric and concentric exercise could maximise the improvements in clinical outcomes and may be ideal for COPD patients. We also expect to unravel the molecular mechanisms underpinning muscle mass regulation after training in severe COPD patients.
- ItemEmphysema and DLCO predict a clinically important difference for 6MWD decline in COPD(2015) Diaz, Alejandro A.; Pinto Plata, Victor; Hernandez, Camila; Peña, Javier; Ramos, Cristóbal; Diaz, Juan C.; Klaassen Lobos, Julieta Isabel; Patino, Cecilia M.; Saldías Peñafiel, Fernando; Díaz Patiño, Orlando
- ItemEvaluación y manejo de la neumonía del adulto adquirida en la comunidad(2014) Saldías Peñafiel, Fernando; Díaz Patiño, Orlando
- ItemFactores pronósticos y sobrevida a mediano plazo de una cohorte de pacientes con cáncer pulmonar atendidos en la red de salud de la Universidad Católica : Período 2007-2011.(2014) Morales, Arturo; Calvo, C.; González Bombardiere, Sergio; Díaz Patiño, Orlando; Saldías Peñafiel, Fernando
- ItemFactores pronósticos, evolución y mortalidad en el adulto inmunocompetente hospitalizado por neumonía neumocócica adquirida en la comunidad(2009) Saldías Peñafiel, Fernando; Viviani García, Paola; Pulgar B., Dahiana; Valenzuela Flores, Francisco Felipe; Paredes Engber, Sebastián; Díaz Patiño, OrlandoBackground: Streptococcus pneumoniae is the main cause of community-acquired pneumonia in adults. Aim: To describe baseline characteristics, risk factors and clinical outcomes of adult patients hospitalized with pneumococcal pneumonia. Material and methods: Prospective study of adult patients admitted for a community acquired pneumonia in a clinical hospital. Immune deficient patients and those with a history of a recent hospitalization were excluded. Results: One hundred fifty one immuno-competent patients, aged 16 to 92 years, 58% males, were studied. Seventy-five percent had other diseases, 26% were admitted to the intensive care unit and 9% needed mechanical ventilation. There were no differences in clinical features, ICU admission or hospital length of stay among bacteremic and non-bacteremic patients. Thirty days lethality for bacteremic and non-bacteremic patients was 10.9% and 11.5%, respectively. The predictive values for lethality of Fine pneumonia severity index and CURB-65 (Confusion, Urea nitrogen, Respiratory rate, Blood pressure, 65 years of age and older) had an area under the ROC curve of 0.8 and 0.69, respectively. Multivariate analysis disclosed blood urea nitrogen over 30 mg/ dL (odds ratio (OR), 6.8), need for mechanical ventilation (OR, 7.4) and diastolic blood pressure below 50 mmHg (OR, 3.9), as significant independent predictors of death. Conclusions: Pneumococcal pneumonia was associated with a substantial rate of complications and mortality. Clinical presentation and outcome did not differ significantly among patients with and without bacteremia.
- ItemInfección pulmonar por Mycobacterium avium complex en el huésped inmunocompetente(2013) Saldías Peñafiel, Fernando; Tirapegui, F.; Díaz Patiño, Orlando
- ItemlSonographic Measurement of the Quadriceps Muscle in Patients With Chronic Obstructive Pulmonary Disease Functional and Clinical Implications(2016) Cruz Montecinos, C.; Guajardo, C.; Montt, E.; Contreras Briceño, Felipe; Torres Castro, R.; Díaz Patiño, Orlando; Cuesta Vargas, A.
- ItemPedometers to enhance physical activity in COPD : a randomised controlled trial(2015) Mendoza, Laura; Horta, Paula; Espinoza, José; Aguilera, Miguel; Balmaceda, Nicolás; Castro, Ariel; Ruiz, Mauricio; Díaz Patiño, Orlando; Hopkinson, Nicholas S.
- ItemPhysiological response to eccentric and concentric cycling in patients with chronic obstructive pulmonary disease(2020) Nickel, R.; Troncoso, F.; Flores, O.; Gonzalez Bartholin, R.; Mackay, K.; Díaz Patiño, Orlando; Jalon, M.; Peñailillo, L.
- ItemPredictores clínicos de bacteriemia en adultos inmunocompetentes hospitalizados por neumonía adquirida en la comunidad(2015) Saldías Peñafiel, Fernando; Reyes B., Tomás; Sáez, Josefina; Rain M., Carmen; Illanes C., Pamela; Briceño Villafane, Catalina Paz; Díaz Patiño, Orlando
- ItemRole of Salmonella enterica exposure in Chilean Crohn's disease patients(2013) Álvarez Lobos, Manuel; Pizarro, D.; Espinoza, A.; Sebastian, V.; Alvarado, J.; Ibáñez Lazo, Patricio Fernando; Quintana Villar, Carlos; Díaz Patiño, Orlando; Kalergis Parra, Alexis Mikes; Bueno Ramírez, Susan
- ItemSíndrome cardiopulmonar por Hantavirus: Utilidad de la monitorización con el sistema PiCCO(2003) Romero Patino; Carlos Miguel; Andresen Hernández, Max Alfonso; Díaz Patiño, Orlando; Tomicic, Vinko; Baraona Reyes, Fernando Exequiel; Mercado Flores, Marcelo Esteban; Pérez C., Carlos; Downey, Patricio; Dougnac Labatut, AlbertoWe report a 68 years old man, farmer from the metropolitan region, admitted with a Hantavirus Cardiopulmonary Syndrome. The diagnosis was made using serologic test and was later confirmed by the Public Health Institute. He evolved to an early multiple organ failure, requiring high concentrations of oxygen and invasive ventilatory assistance, vasopressor drugs and renal replacement therapy. Swan Ganz and PiCCO were used simultaneously for hemodynamic monitoring. Treatment consisted in global support therapy, antimicrobial therapy and systemic corticosteroids. Intrathoracic blood volume was a more reliable parameter than pulmonary capillary wedge pressure for the assessment of preload. As expected in situations of increased vascular permeability, there was an increase in extravascular lung water. There was a good correlation between extravascular lung water and oxygenation parameters (PaO2/FiO2 and oxygenation index). PiCCO system may become a helpful tool in the management of patients with Hantavirus Cardiopulmonary Syndrome
- ItemSobrevida a largo plazo en adultos inmunocompetentes mayores de 60 años hospitalizados por neumonía adquirida en la comunidad(2013) Saldías Peñafiel, Fernando; Maturana, R.; Roman, F.; Díaz Patiño, Orlando
- ItemVariables clínicas y funcionales asociadas al riesgo de muerte en el seguimiento a largo plazo en pacientes con enfermedad pulmonar obstructiva crónica(2018) Saldías Peñafiel, Fernando; Gassmann, J.; Canelo, A.; Díaz Patiño, Orlando