Browsing by Author "Cuello F., Mauricio"
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- Item2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells(2010) Quezada, M.; Diaz, J.; Henriquez, S.; Bravo Castillo, María Loreto; Aranda, E.; Oliva, B.; Villalón, Manuel J.; Kato Cardemil, Sumie Rode; Cuello F., Mauricio; Brosens, J. J.; Lange, C. A.; Owen, Gareth Ivor2-Methoxyestradiol (2ME) is an endogenous metabolite of 17β-estradiol with antiangiogenic and antitumor properties, although its mechanisms of action remain unclear. Progestins in hormone replacement therapy increase the risk of breast cancer. Progesteron
- ItemBreaking through an epigenetic wall Re-activation of Oct4 by KRAB-containing designer zinc finger transcription factors(2013) Juárez Moreno, Karla; Erices, Rafaela; Beltrán, Adriana S.; Stolzenburg, Sabine; Cuello F., Mauricio; Owen, Gareth Ivor; Qian, Haili; Blancafort, Pilar
- ItemCancer of the vagina(2018) Adams, Tracey S.; Cuello F., Mauricio
- ItemCancer of the vulva(2018) Rogers, Linda J.; Cuello F., Mauricio
- ItemCapacidad diagnóstica de la ecografía para detectar cáncer de endometrio en mujeres posmenopaúsicas sintomáticas y asintomáticas: Experiencia de la universidad católica de chile(2014) Raby, T.; Sierra, P.; Tsunekawa, H.; Craig, J.; Carvajal C., Jorge A.; Cuello F., Mauricio
- ItemCharacterization and phenotypic variation with passage number of cultured human endometrial adenocarcinoma cells(2008) Kato Cardemil, Sumie Rode; Villalón, Manuel J.; Cuello F., Mauricio; Owen, Gareth Ivor; Espinoza, Natalia; Lange, Soledad
- ItemIndependent Anti-Angiogenic Capacities of Coagulation Factors X and Xa(2014) Lange, S.; Gonzalez, I.; Pinto, M.; Arce, M.; Valenzuela Bassi, Rodrigo Andrés; Aranda, E.; Elliot, M.; Alvarez, M.; Henriquez, S.; Velasquez, Ever A.; Orge, F.; Oliva, B.; Gonzalez, P.; Villalón, Manuel J.; Cautivo Reyes, Kelly Margarita; Kalergis Parra, Alexis Mikes; Pereira, K.; Mendoza, C.; Saez, C.; Kato Cardemil, Sumie Rode; Cuello F., Mauricio; Parborell, F.; Irusta, G.; Palma, V.; Allende, M.; Owen, Gareth Ivor
- ItemIsoform Alpha of PKC May Contribute to the Maintenance of Pregnancy Myometrial Quiescence in Humans(2013) Jofré, N.; Delpiano, N.; Cuello F., Mauricio; Poblete L., José A.; Vargas Innocenti, Paula Andrea; Carvajal C., Jorge A.
- ItemLabhardt's colpoperineocleisis : subjective results of an alternative treatment for genital prolapse in patients who are not sexually active-2-year follow-up(2014) Pizarro Berdichevsky, Javier Alejandro; Galleguillos Leyton, Gonzalo Ignacio; Cuevas Gallegos, Rodrigo; Blümel, Bernardita; Pattillo Garnham, Alejandro; González, Silvana; Majerson Grinberg, Alejandro; Padilla Pérez, Oslando; Cuello F., Mauricio; Ortiz Castro, Juan Andrés; Goldman, Howard B.
- ItemLeptin promotes a more aggressive behavior of ovarian cancer cells : a potential explanation for a worse prognosis in obese ovarian cancer patients(2015) Cuello F., Mauricio; Kato Cardemil, Sumie Rode; Abarzúa Catalán, L.; Delpiano, A.; García, K.; Sanhueza, C.; Ibáñez Cáceres, Carolina; Brañes Yunusic, Jorge Antonio; Castellón E.; Owen, Gareth Ivor; Trigo, C.
- ItemLeptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells : an explanation for poor outcomes in obese women(2015) Kato Cardemil, Sumie Rode; Abarzúa Catalán, Lorena; Trigo, César; Delpiano, Ana; Sanhueza, Cristobal; García, Karen; Ibáñez Cáceres, Carolina; Hormazábal, Katherine; Díaz Bórquez, Daniela Aida; Brañes Yunusic, Jorge Antonio; Castellón, Enrique; Bravo, Erasmo; Owen, Gareth Ivor; Cuello F., Mauricio
- ItemMechanical Stretch Increases Brain Natriuretic Peptide Production and Secretion in the Human Fetal Membranes(2013) Carvajal C., Jorge A.; Delpiano, A.; Cuello F., Mauricio; Poblete L., José A.
- ItemMulti-Objective Optimization for Personalized Prediction of Venous Thromboembolism in Ovarian Cancer Patients(2020) Fresard, M. E.; Erices Vidal, Rafaela Miguelina; Bravo Castillo, Maria Loreto; Cuello F., Mauricio; Owen, Gareth Ivor; Ibáñez Cáceres, Carolina; Rodríguez Fernández, María
- ItemPaclitaxel-PHBV nanoparticles and their toxicity to endometrial and primary ovarian cancer cells(2013) Vilos, C.; Morales, F.; Solar, P.; Herrera, N.; González Nilo, F.; Aguayo, D.; Mendoza, H.; Bravo Castillo, María Loreto; González, P.; Kato Cardemil, Sumie Rode; Cuello F., Mauricio; Owen, Gareth Ivor
- ItemPatient inflammatory status and CD4+/CD8+ intraepithelial tumor lymphocyte infiltration are predictors of outcomes in high-grade serous ovarian cancer(2018) Pinto, Mauricio P.; Balmaceda, Carlos; Bravo Castillo, María Loreto; Kato Cardemil, Sumie Rode; Villarroel, Alejandra; Owen, Gareth Ivor; Roa Strauch, Juan Carlos Enrique; Cuello F., Mauricio; Ibañez, Carolina
- ItemPlatelets enhance tissue factor protein and metastasis initiating cell markers, and act as chemoattractants increasing the migration of ovarian cancer cells.(2015) Orellana, Renan.; Kato Cardemil, Sumie Rode; Erices, Rafaela.; Bravo Castillo, María Loreto; González Hevia, Pamela Andrea.; Oliva, Bárbara.; Cubillos Alfaro, Sofía María Jesús.; Valdivia Román, Andrés Felipe; Brañes, Jorge; Cuello F., Mauricio; Ibañez, Carolina; Barriga Cosmelli, María Isabel; Bravo, Erasmo.; Alonso, Catalina.; Bustamente, Eva.; Castellon, Enrique.; Hidalgo, Patricia.; Trigo, Cesar.; Panes Becerra, Olga Teresa; Pereira Garcés, Jaime Ignacio; Mezzano, Diego; Owen, Gareth IvorAbstract Background An increase in circulating platelets, or thrombocytosis, is recognized as an independent risk factor of bad prognosis and metastasis in patients with ovarian cancer; however the complex role of platelets in tumor progression has not been fully elucidated. Platelet activation has been associated with an epithelial to mesenchymal transition (EMT), while Tissue Factor (TF) protein expression by cancer cells has been shown to correlate with hypercoagulable state and metastasis. The aim of this work was to determine the effect of platelet-cancer cell interaction on TF and “Metastasis Initiating Cell (MIC)” marker levels and migration in ovarian cancer cell lines and cancer cells isolated from the ascetic fluid of ovarian cancer patients. Methods With informed patient consent, ascitic fluid isolated ovarian cancer cells, cell lines and ovarian cancer spheres were co-cultivated with human platelets. TF, EMT and stem cell marker levels were determined by Western blotting, flow cytometry and RT-PCR. Cancer cell migration was determined by Boyden chambers and the scratch assay. Results The co-culture of patient-derived ovarian cancer cells with platelets causes: 1) a phenotypic change in cancer cells, 2) chemoattraction and cancer cell migration, 3) induced MIC markers (EMT/stemness), 3) increased sphere formation and 4) increased TF protein levels and activity. Conclusions We present the first evidence that platelets act as chemoattractants to cancer cells. Furthermore, platelets promote the formation of ovarian cancer spheres that express MIC markers and the metastatic protein TF. Our results suggest that platelet-cancer cell interaction plays a role in the formation of metastatic foci.
- ItemPólipo endometrial, una causa infrecuente de sangrado genital anormal en la adolescencia(2014) Ralph T., C.; Zajer A., C.; De Petris V., V.; Gejman Enríquez, Roger; Cuello F., MauricioAntecedentes: El sangrado genital anormal es una causa frecuente de consulta en la adolescencia. En este período, la principal causa de sangrado es la metrorragia asociada a ciclos anovulatorios producto de la inmadurez del eje hipotálamo-hipofisario-gonadal. Dentro de las causas infrecuentes de sangrado genital anormal en ese período está el pólipo endometrial. Caso clínico: Presentamos el caso de una niña de 13 años cuya causa de sangrado correspondió a un pólipo endometrial, sospechado por ultrasonografía, resecado mediante histeroscopia y confirmado mediante estudio histológico. Discusión: Pese a su baja incidencia, los pólipos endometriales deben ser considerados como parte del diagnóstico diferencial en adolescentes que consultan por trastorno menstrual, particularmente en aquellos casos sin respuesta a la terapia hormonal y donde la ultrasonografía muestra engrosamiento endometrial.
- ItemLa prevalencia actual de infección genital por Chlamydia trachomatis en adolescentes y mujeres jóvenes chilenas asintomáticas justifica la vigilancia periódica(2016) Zamboni Torres, Milena; Ralph, Constanza; García Cañete, Patricia; Cuello F., Mauricio
- ItemProgesterone regulation of tissue factor depends on MEK1/2 activation and requires the proline-rich site on progesterone receptor(2015) Bravo Castillo, María Loreto; Pinto, Mauricio P.; González, Ibeth; Oliva, Bárbara; Kato Cardemil, Sumie Rode; Cuello F., Mauricio; Lange, Carol A.; Owen, Gareth Ivor
- ItemTécnica para cultivar y expandir células de cáncer extraídas de fluido ascitico y su exposición a concentraciones específicas de regímenes de quimioterapia (Chile, concesión n° 55061)Owen, Gareth Ivor; Bravo Castillo, María Loreto; González, Pamela; Kato Cardemil, Sumie Rode; Cuello F., Mauricio; Orellana Walden, Renán Felipe