Browsing by Author "Cruzat Corssen, Andrea"
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- ItemAngle Anatomy and Glaucoma in Patients With Boston Keratoprosthesis(2020) Silva, Rafaella Nascimento e; Taniguchi, Elise V.; Cruzat Corssen, Andrea; Paschalis, Eleftherios I.; Pasquale, Louis R.; Colby, Kathryn A.; Dohlman, Claes H.; Chodosh, James; Shen, Lucy Q.Purpose: To quantitatively analyze the angle anatomy in eyes with a Boston type 1 keratoprosthesis (KPro) using anterior segment optical coherence tomography (AS-OCT) and to assess the diagnostic ability of AS-OCT in KPro-associated glaucoma. Methods: AS-OCT (RTVue) images from KPro eyes with and without glaucoma were reviewed. The angle opening distance at 500 mu m from the scleral spur (AOD500), trabecular-iris angle at 500 mu m from the scleral spur (TIA500), and trabecular-iris surface area at 500 mu m from the scleral spur (TISA500) were measured by 2 observers masked to the diagnosis. The measurements for each visible quadrant were compared between KPro eyes with and without glaucoma. Results: Twenty-two eyes with glaucoma and 17 eyes without glaucoma from 39 patients with KPro were included. Of the 4 quadrants imaged, the temporal angle was the most visible (79.5%) and angle measurements of the temporal quadrant were the only ones that differentiated the 2 groups: the mean AOD500, TIA500, and TISA500 were significantly lower in KPro eyes with glaucoma than without glaucoma (388.2 +/- 234.4 mu m vs. 624.5 +/- 310.5 mu m,P= 0.02; 26.1 +/- 14.0 degrees vs. 39.1 +/- 17.1 degrees,P= 0.03; and 0.15 +/- 0.09 mm(2)vs. 0.23 +/- 0.12 mm(2),P= 0.03; respectively). The highest area under the receiver operating characteristic curve for detecting glaucoma was 0.75 for temporal TIA500 (95% confidence interval 0.57-0.94,P= 0.02) with 50% specificity at 80% of sensitivity and a cutoff value of 37 degrees. Conclusions: The temporal angle was the most visible on AS-OCT in eyes with a KPro. Significant narrowing of the temporal angle detected on AS-OCT was associated with glaucoma in these eyes.
- ItemClinical Outcomes Using Oversized Back Plates in Type I Boston Keratoprosthesis(2018) Kaufman, Aaron R.; Cruzat Corssen, Andrea; Colby, Kathryn A.
- ItemColocalization of Galectin-3 With CD147 Is Associated With Increased Gelatinolytic Activity in Ulcerating Human Corneas(2018) Cruzat Corssen, Andrea; Gonzalez-Andrades, Miguel; Mauris, Jerome; AbuSamra, Dina B.; Chidambaram, Preethi; Kenyon, Kenneth R.; Chodosh, James; Dohlman, Claes H.; Argueso, Pablo
- ItemContralateral clinically unaffected eyes of patients with unilateral infectious keratitis demonstrate a sympathetic immune response(2015) Cruzat Corssen, Andrea; Schrems, Wolfgang A.; Schrems-Hoesl, Laura M.; Cavalcanti, Bernardo M.; Baniasadi, Neda; Witkin, Deborah; Pavan-Langston, Deborah; Dana, Reza; Hamrah, Pedram
- ItemCorneal epithelial immune dendritic cell alterations in subtypes of dry eye disease : a pilot in vivo confocal microscopic study(2015) Kheirkhah, Ahmad; Darabad, Raheleh Rahimi; Cruzat Corssen, Andrea; Reza Hajrasouliha, Amir; Witkin, Deborah; Wong, Nadia; Dana, Reza; Hamrah, Pedram
- ItemCorneal nerve regeneration is affected by scar location in herpes simplex keratitis: A longitudinal in vivo confocal microscopy study(2023) Posarelli, Matteo; Chirapapaisan, Chareenun; Müller, Rodrigo; Abbouda, Alessandro; Pondelis, Nicholas; Cruzat Corssen, Andrea; Cavalcanti, Bernardo M.; Cox, Stephanie M.; Jamali, Arsia; Pavan-Langston, Deborah; Hamrah, PedramPurpose: To assess the effect of corneal scar location on corneal nerve regeneration in patients with herpes simplex virus (HSV) keratitis in their affected and contralateral eyes over a 1-year period by in vivo confocal microscopy (IVCM), and to correlate these findings to corneal sensation measured by Cochet-Bonnet Esthesiometer. Methods: Prospective, longitudinal, case-control study. Bilateral corneal nerve density and corneal sensation were analyzed centrally and peripherally in 24 healthy controls and 23 patients with unilateral HSV-related corneal scars using IVCM. Results: In the central scar (CS) group, total nerve density in the central cornea remained significantly lower compared to controls at follow-up (11.05 ± 1.97mm/mm2, p < 0.001), and no significant nerve regeneration was observed (p = 0.090). At follow-up, total nerve density was not significantly different from controls in the central and peripheral cornea of the peripheral scar (PS) group (all p > 0.05), but significant nerve regeneration was observed in central corneas (16.39 ± 2.39mm/mm2, p = 0.007) compared to baseline. In contralateral eyes, no significant corneal nerve regeneration was observed in central or peripheral corneas of patients with central scars or peripheral scars at 1-year follow-up, compared to baseline (p > 0.05). There was a positive correlation between corneal nerve density and sensation in both central (R = 0.53, p < 0.0001) and peripheral corneas (R = 0.27, p = 0.0004). In the CS group, the corneal sensitivity was <4 cm in 4 (30.8%) and 7 (53.8%) patients in the central and peripheral corneas at baseline, and in 5 (38.5%) and 2 subjects (15.4%) at follow-up, whereas in the PS group only 1 patient (10%) showed a corneal sensation < 4 cm in the central cornea at baseline, and only 1 (10.0%), 3 (30.0%) and 1 (10.0%) patients at follow-up in the central, affected and opposite area of the cornea, respectively. Conclusion: The location of HSV scarring in the cornea affects the level of corneal nerve regeneration. Eyes with central corneal scar have a diminished capacity to regenerate nerves in central cornea, show a more severe reduction in corneal sensation in the central and peripheral corneas that persist at follow-up, and have a reduced capability to restore the corneal sensitivity above the cut-off of 4 cm. Thus, clinicians should be aware that CS patients would benefit from closer monitoring for potential complications associated with neurotrophic keratopathy, as they have a lower likelihood for nerve regeneration.
- ItemCorrelation of corneal immune cell changes with clinical severity in dry eye disease : An in vivo confocal microscopy study(2020) Aggarwal, S.; Kheirkhah, A.; Cavalcanti, B. M.; Cruzat Corssen, Andrea; Jamali, A.; Hamrah, P.
- ItemEfectividad del moxifloxacino intracameral para reducir la Endoftalmitis posterior a cirugía de cataratas en población chilena(2023) Garretón Cárcamo, Rodolfo Ignacio; Liberman Salazar, Paulina; Sanhueza Pasten, Camila Alejandra; Cruzat Corssen, Andrea; Coria, MarceloEstudio de cohorte no concurrente cuyo propósito fue evaluar la efectividad del moxifloxacino intracameral profiláctico para reducir la frecuencia de endoftalmitis posterior a cirugía de cataratas en el Hospital Dr. Sótero del Río. Se revisaron todos los registros quirúrgicos entre el 2012 y el 2020, evaluando si se utilizó moxifloxacino intracameral. Posteriormente se registraron todos los pacientes que recibieron tratamiento por endoftalmitis, y se evaluaron sus características, si hubo uso de moxifloxacino y si la cirugía tuvo alguna complicación. Se encontraron 22.869 cirugías de cataratas, con un promedio de 2.541 operaciones anuales. El moxifloxacino intracameral se comenzó a usar el 2014 progresivamente, ocupándose en un 80% de las cirugías en el 2018. 15 ojos evolucionaron con endoftalmitis. Hubo una tendencia a favor del uso de moxifloxacino intracameral, sin embargo, esto no fue estadísticamente significativo. En el grupo de endoftalmitis, 33,3% tenían diabetes mellitus, en 13,3% hubo rotura de capsula posterior y 60% eran de pacientes mujeres. No hay registro de endoftalmitis entre el 2018 y el 2020 luego de cirugía de cataratas. En conclusión, a pesar de haber una tendencia a favor del uso de moxifloxacino intracameral, se requiere un periodo mayor de observación para confirmar esta hipótesis.
- ItemEffect of herpes simplex keratitis scar location on bilateral corneal nerve alterations : An in vivo confocal microscopy study(2020) Chirapapaisan, C.; Muller, R. T.; Sahin, A.; Cruzat Corssen, Andrea; Cavalcanti, B. M.; Jamali, A.; Pavan-Langston, D.; Hamrah, P.
- ItemEffects of gamma radiation sterilization on the structural and biological properties of decellularized corneal xenografts(2019) Islam, Mohammad Mirazul; Sharifi, Roholah; Mamodaly, Shamina; Islam, Rakibul; Nahra, Daniel; Abusamra, Dina B.; Chuen Hui, Pui; Adibnia, Yashar; Goulamaly, Mehdi; Paschalis, Eleftherios I.; Cruzat Corssen, Andrea; Kong, Jing; Nilsson, Per H.; Argüeso, Pablo; Mollnes, Tom Eirik; Chodosh, James; Dohlman, Claes H.; González-Andrades, MiguelTo address the shortcomings associated with corneal transplants, substantial efforts have been focused on developing new modalities such as xenotransplantion. Xenogeneic corneas are anatomically and biomechanically similar to the human cornea, yet their applications require prior decellularization to remove the antigenic components to avoid rejection. In the context of bringing decellularized corneas into clinical use, sterilization is a crucial step that determines the success of the transplantation. Well-standardized sterilization methods, such as gamma irradiation (GI), have been applied to decellularized porcine corneas (DPC) to avoid graft-associated infections in human recipients. However, little is known about the effect of GI on decellularized corneal xenografts. Here, we evaluated the radiation effect on the ultrastructure, optical, mechanical and biological properties of DPC. Transmission electron microscopy revealed that gamma irradiated decellularized porcine cornea (G-DPC) preserved its structural integrity. Moreover, the radiation did not reduce the optical properties of the tissue. Neither DPC nor G-DPC led to further activation of complement system compared to native porcine cornea when exposed to plasma. Although, DPC were mechanically comparable to the native tissue, GI increased the mechanical strength, tissue hydrophobicity and resistance to enzymatic degradation. Despite these changes, human corneal epithelial, stromal, endothelial and hybrid neuroblastoma cells grew and differentiated on DPC and G-DPC. Thus, GI may achieve effective tissue sterilization without affecting critical properties that are essential for corneal transplant survival. (C) 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
- ItemEx Vivo Study of Transepithelial Corneal Cross-linking(2017) Cruzat Corssen, Andrea; Shukla, A.; Arafat, S.; Alageel, S.; Colon, C.; Chodosh, J.; Ciolino, J.
- ItemImproving the practicality and safety of artificial corneas : Pre-assembly and gamma-rays sterilization of the Boston Keratoprosthesis(2018) Gonzalez Andrades, M.; Sharifi, R.; Islam, M.M.; Divoux, T.; Haist, M.; Paschalis, E.I.; Gelfand, L.; Mamodaly, S.; Di Cecilia, L.; Cruzat Corssen, Andrea; Ulm, F.J.; Chodosh, J.; Delori, F.; Dohlman, C.H.
- ItemIn Vivo Confocal Microscopy of Corneal Nerves in Health and Disease(2017) Cruzat Corssen, Andrea; Qazi, Y.; Hamrah, P.
- ItemOpen-care telemedicine in ophthalmology during the COVID-19 pandemic : a pilot study(2020) Arntz Bustos, Teodoro Alberto; Khaliliyeh, D.; Cruzat Corssen, Andrea; Rao, X.; Rocha Muñoz, Germán Alberto; Grau Diez, Arturo Eduardo; Altschwager Kreft, Pablo Andrés; Azócar Garrido, Víctor Hugo
- ItemRandomized masked trial of the clinical efficacy of MGO Manuka Honey microemulsion eye cream for the treatment of blepharitis(2020) Craig, JP; Cruzat Corssen, Andrea; Cheung, IMY; Watters, GA; Wang, MTM
- ItemThe Role of the Back Plate in Angle Anatomy with the Boston Type I Keratoprosthesis(2017) Taniguchi, Elise V.; Paschalis, Eleftherios I.; Crne, Aljaj; Ren, Ai; Colby, Kathryn A.; Chodosh, James; Pasquale, Louis R.; Shen, Lucy Q.; Dohlman, Claes H.; Cruzat Corssen, Andrea