Browsing by Author "Crossley Karmelic, Nicolás Andrés"
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- ItemGender, age and geographical representation over the past 50 years of schizophrenia research(2022) Alliende, Luz MarÍa; Czepielewski, Leticia S.; Aceituno Farías, David; Paz Castaneda, Carmen; Díaz, Camila; Iruretagoyena Bruce, Bárbara Arantzazu; Mena, Carlos; Mena, Cristian; Ramírez Mahaluf, Juan Pablo; Tepper, Ángeles; Vásquez, Javiera; Fonseca, Lais; Machado, Viviane; Hernández, Camilo E.; Vargas Upegui, Cristian; Gómez Cruz, Gladys; Kobayashi Romero, Luis F.; Moncada Habib, Tomas; Evans Lacko, Sara; Bressan, Rodrigo; Gama, Clarissa S.; López Jaramillo, Carlos; de la Fuente Sandoval, Camilo; González Valderrama, Alfonso; Undurraga, Juan; Gadelha, Ary; Crossley Karmelic, Nicolás Andrés; ANDES NetworkPrevious studies have suggested that subjects participating in schizophrenia research are not representative of the demographics of the global population of people with schizophrenia, particularly in terms of gender and geographical location. We here explored if this has evolved throughout the decades, examining changes in geographical location, gender and age of participants in studies of schizophrenia published in the last 50 years. We examined this using a meta-analytical approach on an existing database including over 3,000 studies collated for another project. We found that the proportion of studies and participants from low-and-middle income countries has significantly increased over time, with considerable input from studies from China. However, it is still low when compared to the global population they represent. Women have been historically underrepresented in studies, and still are in high-income countries. However, a significantly higher proportion of female participants have been included in studies over time. The age of participants included has not changed significantly over time. Overall, there have been improvements in the geographical and gender representation of people with schizophrenia. However, there is still a long way to go so research can be representative of the global population of people with schizophrenia, particularly in geographical terms.
- ItemPhysical and mental health impact of COVID-19 on children, adolescents, and their families: The Collaborative Outcomes study on Health and Functioning during Infection Times-Children and Adolescents (COH-FIT-C&A)(2022) Solmi, Marco; Estrade, Andres; Thompson, Trevor; Agorastos, Agorastos; Radua, Joaquim; Cortese, Samuele; Dragioti, Elena; Leisch, Friedrich; Vancampfort, Davy; Thygesen, Lau Caspar; Aschauer, Harald; Schloegelhofer, Monika; Akimova, Elena; Schneeberger, Andres; Huber, Christian G.; Hasler, Gregor; Conus, Philippe; Do Cuenod, Kim Q.; von Kanel, Roland; Arrondo, Gonzalo; Fusar Poli, Paolo; Gorwood, Philip; Llorca, Pierre Michel; Krebs, Marie Odile; Scanferla, Elisabetta; Kishimoto, Taishiro; Rabbani, Golam; Skonieczna Zydecka, Karolina; Brambilla, Paolo; Favaro, Angela; Takamiya, Akihiro; Zoccante, Leonardo; Colizzi, Marco; Bourgin, Julie; Kaminski, Karol; Moghadasin, Maryam; Seedat, Soraya; Matthews, Evan; Wells, John; Vassilopoulou, Emilia; Gadelha, Ary; Su, Kuan Pin; Kwon, Jun Soo; Kim, Minah; Lee, Tae Young; Papsuev, Oleg; Mankova, Denisa; Boscutti, Andrea; Gerunda, Cristiano; Saccon, Diego; Righi, Elena; Monaco, Francesco; Croatto, Giovanni; Cereda, Guido; Demurtas, Jacopo; Brondino, Natascia; Veronese, Nicola; Enrico, Paolo; Politi, Pierluigi; Ciappolino, Valentina; Pfennig, Andrea; Bechdolf, Andreas; Meyer Lindenberg, Andreas; Kahl, Kai G.; Domschke, Katharina; Bauer, Michael; Koutsouleris, Nikolaos; Winter, Sibylle; Borgwardt, Stefan; Bitter, Istvan; Balazs, Judit; Czobor, Pal; Unoka, Zsolt; Mavridis, Dimitris; Tsamakis, Konstantinos; Bozikas, Vasilios P.; Tunvirachaisakul, Chavit; Maes, Michael; Rungnirundorn, Teerayuth; Supasitthumrong, Thitiporn; Haque, Ariful; Brunoni, Andre R.; Costardi, Carlos Gustavo; Schuch, Felipe Barreto; Polanczyk, Guilherme; Luiz, Jhoanne Merlyn; Fonseca, Lais; Aparicio, Luana, V; Valvassori, Samira S.; Nordentoft, Merete; Vendsborg, Per; Hoffmann, Sofie Have; Sehli, Jihed; Sartorius, Norman; Heuss, Sabina; Guinart, Daniel; Hamilton, Jane; Kane, John; Rubio, Jose; Sand, Michael; Koyanagi, Ai; Solanes, Aleix; Andreu Bernabeu, Alvaro; Caceres, Antonia San Jose; Arango, Celso; Diaz Caneja, Covadonga M.; Hidalgo Mazzei, Diego; Vieta, Eduard; Gonzalez Penas, Javier; Fortea, Lydia; Parellada, Mara; Fullana, Miquel A.; Verdolini, Norma; Farkova, Eva; Janku, Karolina; Millan, Mark; Honciuc, Mihaela; Moniuszko Malinowska, Anna; Loniewski, Igor; Samochowiec, Jerzy; Kiszkiel, Lukasz; Marlicz, Maria; Sowa, Pawel; Marlicz, Wojciech; Spies, Georgina; Stubbs, Brendon; Firth, Joseph; Sullivan, Sarah; Darcin, Asli Enez; Aksu, Hatice; Dilbaz, Nesrin; Noyan, Onur; Kitazawa, Momoko; Kurokawa, Shunya; Tazawa, Yuki; Anselmi, Alejandro; Cracco, Cecilia; Machado, Ana Ines; Estrade, Natalia; De Leo, Diego; Curtis, Jackie; Berk, Michael; Ward, Philip; Teasdale, Scott; Rosenbaum, Simon; Marx, Wolfgang; Horodnic, Adrian Vasile; Oprea, Liviu; Alexinschi, Ovidiu; Ifteni, Petru; Turliuc, Serban; Ciuhodaru, Tudor; Bolos, Alexandra; Matei, Valentin; Nieman, Dorien H.; Sommer, Iris; van Os, Jim; van Amelsvoort, Therese; Sun, Ching Fang; Guu, Ta Wei; Jiao, Can; Zhang, Jieting; Fan, Jialin; Zou, Liye; Yu, Xin; Chi, Xinli; de Timary, Philippe; van Winke, Ruud; Ng, Bernardo; Pena, Edilberto; Arellano, Ramon; Roman, Raquel; Sanchez, Thelma; Movina, Larisa; Morgado, Pedro; Brissos, Sofia; Aizberg, Oleg; Mosina, Anna; Krinitski, Damir; Mugisha, James; Sadeghi Bahmani, Dena; Sadeghi, Masoud; Hadi, Samira; Brand, Serge; Errázuriz Concha, Antonia; Crossley Karmelic, Nicolás Andrés; Ristic, Dragana Ignjatovic; Lopez Jaramillo, Carlos; Efthymiou, Dimitris; Kuttichira, Praveenlal; Kallivayalil, Roy Abraham; Javed, Afzal; Afridi, Muhammad Iqbal; James, Bawo; Seb Akahomen, Omonefe Joy; Fiedorowicz, Jess; Carvalho, Andre F.; Daskalakis, Jeff; Yatham, Lakshmi N.; Yang, Lin; Okasha, Tarek; Dahdouh, Aicha; Gerdle, Bjorn; Tiihonen, Jari; Shin, Jae Il; Lee, Jinhee; Mhalla, Ahmed; Gaha, Lotfi; Brahim, Takoua; Altynbekov, Kuanysh; Negay, Nikolay; Nurmagambetova, Saltanat; Abu Jamei, Yasser; Weiser, Mark; Correll, Christoph U.Background: The COVID-19 pandemic has altered daily routines and family functioning, led to closing schools, and dramatically limited social interactions worldwide. Measuring its impact on mental health of vulnerable children and adolescents is crucial. Methods: The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT - www. coh-fit.com) is an on-line anonymous survey, available in 30 languages, involving >230 investigators from 49 countries supported by national/international professional associations. COH-FIT has thee waves (until the pandemic is declared over by the WHO, and 6-18 months plus 24-36 months after its end). In addition to adults, COH-FIT also includes adolescents (age 14-17 years), and children (age 6-13 years), recruited via nonprobability/snowball and representative sampling and assessed via self-rating and parental rating. Nonmodifiable/modifiable risk factors/treatment targets to inform prevention/intervention programs to promote health and prevent mental and physical illness in children and adolescents will be generated by COH-FIT. Co primary outcomes are changes in well-being (WHO-5) and a composite psychopathology P-Score. Multiple behavioral, family, coping strategy and service utilization factors are also assessed, including functioning and quality of life. Results: Up to June 2021, over 13,000 children and adolescents from 59 countries have participated in the COHFIT project, with representative samples from eleven countries. Limitations: Cross-sectional and anonymous design. Conclusions: Evidence generated by COH-FIT will provide an international estimate of the COVID-19 effect on children's, adolescents' and families', mental and physical health, well-being, functioning and quality of life, informing the formulation of present and future evidence-based interventions and policies to minimize adverse effects of the present and future pandemics on youth.
- ItemRegional brain atrophy is related to social cognition impairment in multiple sclerosis(ASSOC ARQUIVOS NEURO- PSIQUIATRIA, 2021) Labbe Atenas, Tomás Pablo; Montalba Zalaquett, Cristian Andrés; Zurita Soler, Mariana; Ciampi Diaz, Ethel Leslie; Albornoz Cruz, Juan Pablo; Vásquez Torres, Macarena; Uribe Arancibia, Sergio Andrés; Crossley Karmelic, Nicolás Andrés; Cárcamo Rodríguez, Claudia AndreaBackground: Multiple sclerosis exhibits specific neuropathological phenomena driving to both global and regional brain atrophy. At the clinical level, the disease is related to functional decline in cognitive domains as the working memory, processing speed, and verbal fluency. However, the compromise of social-cognitive abilities has concentrated some interest in recent years despite the available evidence suggesting the risk of disorganization in social life. Recent studies have used the MiniSEA test to assess the compromise of social cognition and have found relevant relationships with memory and executive functions, as well as with the level of global and regional brain atrophy. Objective: The present article aimed to identify structural changes related to socio-cognitive performance in a sample of patients with relapsing-remitting multiple sclerosis. Methods: 68 relapsing-remitting multiple sclerosis Chilean patients and 50 healthy control subjects underwent MRI scans and neuropsychological evaluation including social-cognition tasks. Total brain, white matter, and gray matter volumes were estimated. Also, voxel-based morphometry was applied to evaluate regional structural changes. Results: Patients exhibited lower scores in all neuropsychological tests. Social cognition exhibited a significant decrease in this group mostly related to the declining social perception. Normalized brain volume and white matter volume were significantly decreased when compared to healthy subjects. The regional brain atrophy analysis showed that changes in the insular cortex and medial frontal cortices are significantly related to the variability of social-cognitive performance among patients. Conclusions: In the present study, social cognition was only correlated with the deterioration of verbal fluency, despite the fact that previous studies have reported its link with memory and executive functions. The identification of specific structural correlates supports the comprehension of this phenomenon as an independent source of cognitive disability in these patients.
- ItemStructural brain abnormalities in schizophrenia in adverse environments: Examining the effect of poverty and violence in six Latin American cities(2021) Crossley Karmelic, Nicolás Andrés; Zugman, Andre; Reyes-Madrigal, Francisco; Czepielewski, Leticia S.; Castro, Mariana N.; Díaz-Zuluaga, Ana M.; Pineda-Zapata, Julián A.; Reckziegel, Ramiro; Noto, Cristiano; Jackowski, Andrea; Alliende, Luz M.; Iruretagoyena, Bárbara; Ossandon, Tomás; Ramirez-Mahaluf, Juan P.; Castañeda, Carmen; González-Valderrama, Alfonso; Nachar, Rubén; León-Ortiz, Pablo; Undurraga, Juan; López-Jaramillo, Carlos; Guinjoan, Salvador; Gama, Clarissa; Fuente-Sandoval, Camilo de la; Bressan, RodrigoBackground: Social and environmental factors such as poverty or violence modulate the risk and course of schizophrenia. However, how they affect the brain in patients with psychosis remains unclear. Aims: We studied how environmental factors are related to brain structure in patients with schizophrenia and controls in Latin America, where these factors are large and unequally distributed. Method: This is a multicentre study of magnetic resonance imaging in patients with schizophrenia andcontrols fromsixLatinAmerican cities. Total and voxel-level grey matter volumes, and their relationship with neighbourhood characteristics such as average income and homicide rates, were analysed with a general linear model. Results: Atotal of 334 patients with schizophrenia and 262 controls were included. Income was differentially related to total grey matter volume in both groups (P=0.006). Controls showed a positive correlation between total grey matter volume and The risk of developing schizophrenia is modulated, among other factors, by the social and environmental context of where people live. Incidence rates of psychosis are different across countries,1 possibly reflecting variations in the environment. Proposed specific factors explaining this effect have included an urban upbringing,2 poverty3 and the neighbourhood crime rate.4 Where people live has also been related to recovery rates of schizophrenia, in the context of whether it is a low- or high-income country5 or experiencing periods of economic expansion or recession.6 Brain imaging studies have shown that many of these environmental factors are related to brain changes in healthy individuals. For example, young people raised in poverty in high-income countries show reductions in total brain grey matter.7 Exposure to childhood adversity and violence has also been related to differences in hippocampal and amygdala volumes.8 An unresolved question relates to how these environmental factors affect the biology of schizophrenia. Couldbraindifferences typically seen in patients with schizophrenia be accounted for by these environmental factors? How will the neuropathology of schizophrenia interact with brain changes related to the environment? Is there a double-hit situation, where * Joint last authors. 112 income(R=0.14, P=0.02). Surprisingly, this relationship was not present in patients with schizophrenia (R=−0.076, P=0.17). Voxel-level analysis confirmed that this interaction was widespread across the cortex. After adjusting for global brain changes, income was positively related to prefrontal cortex volumes only in controls. Conversely, the hippocampus in patients with schizophrenia, but not in controls, was relatively larger in affluent environments. There was no significant correlation between environmental violence and brain structure.
- ItemThe collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic(2022) Solmi, Marco; Estrade, Andrés; Thompson, Trevor; Agorastos, Agorastos; Radua, Joaquim; Cortese, Samuele; Dragioti, Elena; Leisch, Friedrich; Vancampfort, Davy; Thygesen, Lau Caspar; Aschauer, Harald; Schloegelhofer, Monika; Akimova, Elena; Schneeberger, Andres; Huber, Christian G.; Hasler, Gregor; Conus, Philippe; Do Cuenod, Kim Q.; von Kanel, Roland; Arrondo, Gonzalo; Fusar Poli, Paolo; Gorwood, Philip; Llorca, Pierre Michel; Krebs, Marie Odile; Scanferla, Elisabetta; Kishimoto, Taishiro; Rabbani, Golam; Skonieczna Zydecka, Karolina; Brambilla, Paolo; Favaro, Angela; Takamiya, Akihiro; Zoccante, Leonardo; Colizzi, Marco; Bourgin, Julie; Kaminski, Karol; Moghadasin, Maryam; Seedat, Soraya; Matthews, Evan; Wells, John; Vassilopoulou, Emilia; Gadelha, Ary; Su, Kuan Pin; Kwon, Jun Soo; Kim, Minah; Lee, Tae Young; Papsuev, Oleg; Mankova, Denisa; Boscutti, Andrea; Gerunda, Cristiano; Saccon, Diego; Righi, Elena; Monaco, Francesco; Croatto, Giovanni; Cereda, Guido; Demurtas, Jacopo; Brondino, Natascia; Veronese, Nicola; Enrico, Paolo; Politi, Pierluigi; Ciappolino, Valentina; Pfennig, Andrea; Bechdolf, Andreas; Meyer Lindenberg, Andreas; Kahl, Kai G.; Domschke, Katharina; Bauer, Michael; Koutsouleris, Nikolaos; Winter, Sibylle; Borgwardt, Stefan; Bitter, Istvan; Balazs, Judit; Czobor, Pal; Unoka, Zsolt; Mavridis, Dimitris; Tsamakis, Konstantinos; Bozikas, Vasilios P.; Tunvirachaisakul, Chavit; Maes, Michael; Rungnirundorn, Teerayuth; Supasitthumrong, Thitiporn; Haque, Ariful; Brunoni, Andre R.; Costardi, Carlos Gustavo; Schuch, Felipe Barreto; Polanczyk, Guilherme; Luiz, Jhoanne Merlyn; Fonseca, Lais; Aparicio, Luana, V; Valvassori, Samira S.; Nordentoft, Merete; Vendsborg, Per; Hoffmann, Sofie Have; Sehli, Jihed; Sartorius, Norman; Heuss, Sabina; Guinart, Daniel; Hamilton, Jane; Kane, John; Rubio, Jose; Sand, Michael; Koyanagi, Ai; Solanes, Aleix; Andreu Bernabeu, Alvaro; San Jose Caceres, Antonia; Arango, Celso; Diaz Caneja, Covadonga M.; Hidalgo Mazzei, Diego; Vieta, Eduard; Gonzalez Penas, Javier; Fortea, Lydia; Parellada, Mara; Fullana, Miquel A.; Verdolini, Norma; Farkova, Eva; Janku, Karolina; Millan, Mark; Honciuc, Mihaela; Moniuszko Malinowska, Anna; Loniewski, Igor; Samochowiec, Jerzy; Kiszkiel, Lukasz; Marlicz, Maria; Sowa, Pawel; Marlicz, Wojciech; Spies, Georgina; Stubbs, Brendon; Firth, Joseph; Sullivan, Sarah; Darcin, Asli Enez; Aksu, Hatice; Dilbaz, Nesrin; Noyan, Onur; Kitazawa, Momoko; Kurokawa, Shunya; Tazawa, Yuki; Anselmi, Alejandro; Cracco, Cecilia; Ines Machado, Ana; Estrade, Natalia; De Leo, Diego; Curtis, Jackie; Berk, Michael; Ward, Philip; Teasdale, Scott; Rosenbaum, Simon; Marx, Wolfgang; Horodnic, Adrian Vasile; Oprea, Liviu; Alexinschi, Ovidiu; Ifteni, Petru; Turliuc, Serban; Ciuhodaru, Tudor; Bolos, Alexandra; Matei, Valentin; Nieman, Dorien H.; Sommer, Iris; van Os, Jim; van Amelsvoort, Therese; Sun, Ching Fang; Guu, Ta wei; Jiao, Can; Zhang, Jieting; Fan, Jialin; Zou, Liye; Yu, Xin; Chi, Xinli; de Timary, Philippe; van Winke, Ruud; Ng, Bernardo; Pena, Edilberto; Arellano, Ramon; Roman, Raquel; Sanchez, Thelma; Movina, Larisa; Morgado, Pedro; Brissos, Sofia; Aizberg, Oleg; Mosina, Anna; Krinitski, Damir; Mugisha, James; Sadeghi Bahmani, Dena; Sadeghi, Masoud; Hadi, Samira; Brand, Serge; Errázuriz Concha, Antonia; Crossley Karmelic, Nicolás Andrés; Ristic, Dragana Ignjatovic; Lopez Jaramillo, Carlos; Efthymiou, Dimitris; Kuttichira, Praveenlal; Kallivayalil, Roy Abraham; Javed, Afzal; Afridi, Muhammad Iqbal; James, Bawo; Seb Akahomen, Omonefe Joy; Fiedorowicz, Jess; Carvalho, Andre F.; Daskalakis, Jeff; Yatham, Lakshmi N.; Yang, Lin; Okasha, Tarek; Dahdouh, Aicha; Gerdle, Bjorn; Tiihonen, Jari; Shin, Jae Il; Lee, Jinhee; Mhalla, Ahmed; Gaha, Lotfi; Brahim, Takoua; Altynbekov, Kuanysh; Negay, Nikolay; Nurmagambetova, Saltanat; Abu Jamei, Yasser; Weiser, Mark; Correll, Christoph U.Background: . High-quality comprehensive data on short-/long-term physical/mental health effects of the COVID-19 pandemic are needed.
- ItemValidation of the Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) questionnaire for adults(2023) Solmi M.; Fiedorowicz J.; Dragioti E.; Estrade A.; Radua J.; Fusar-Poli P.; Winter S.; Correll C.U.; Thompson T.; Anselmi A.; Cracco C.; Machado A.I.; Estrade N.; Agorastos A.; Bozikas V.P.; Solanes A.; Fortea L.; Fullana M.A.; Tiihonen J.; Cortese S.; Arrondo G.; Gerdle B.; Leisch F.; Vancampfort D.; Thygesen L.C.; Hoffmann S.H.; Aschauer H.; Schlogelhofer M.; Aschauer E.; Schneeberger A.; Huber C.G.; Hasler G.; Sehli J.; Conus P.; Do Cuenod K.Q.; von Kanel R.; Brondino N.; Politi P.; Gorwood P.; Scanferla E.; Krebs M.-O.; Llorca P.-M.; Honciuc M.; Kishimoto T.; Takamiya A.; Kitazawa M.; Kurokawa S.; Tazawa Y.; Rabbani G.; Haque A.; Skonieczna-Zydecka K.; Loniewski I.; Marlicz M.; Brambilla P.; Boscutti A.; Cereda G.; Enrico P.; Ciappolino V.; Favaro A.; Gerunda C.; Zoccante L.; Colizzi M.; Bourgin J.; Kaminski K.; Sowa P.; Moghadasin M.; Seedat S.; Spies G.; Matthews E.; Wells J.; Vassilopoulou E.; Efthymiou D.; Gadelha A.; Costardi C.G.; Fonseca L.; Su K.-P.; Kwon J.S.; Kim M.; Lee T.Y.; Papsuev O.; Movina L.; Mankova D.; Andrlikova E.; Janku K.; Saccon D.; Righi E.; Monaco F.; Croatto G.; Demurtas J.; Veronese N.; Pfennig A.; Bauer M.; Bechdolf A.; Meyer-Lindenberg A.; Kahl K.G.; Domschke K.; Koutsouleris N.; Borgwardt S.; Bitter I.; Czobor P.; Unoka Z.; Balazs J.; Mavridis D.; Tsamakis K.; Tunvirachaisakul C.; Maes M.; Rungnirundorn T.; Supasitthumrong T.; Brunoni A.R.; Polanczyk G.; Aparicio L.V.; Schuch F.B.; Luiz J.M.; Valvassori S.S.; Nordentoft M.; Vendsborg P.; Sartorius N.; Heuss S.; Guinart D.; Kane J.; Rubio J.; Hamilton J.; Sand M.; Koyanagi A.; Andreu-Bernabeu A.; Caceres A.S.J.; Arango C.; Diaz-Caneja C.M.; Gonzalez-Penas J.; Parellada M.; Hidalgo-Mazzei D.; Vieta E.; Verdolini N.; Millan M.J.; Moniuszko-Malinowska A.; Samochowiec J.; Kiszkiel L.; Marlicz W.; Stubbs B.; Firth J.; Sullivan S.; Darcin A.E.; Aksu H.; Dilbaz N.; Noyan O.; De Leo D.; Curtis J.; Berk M.; Teasdale S.; Marx W.; Carvalho A.F.; Ward P.; Rosenbaum S.; Horodnic A.V.; Oprea L.; Turliuc S.; Bolos A.; Alexinschi O.; Ifteni P.; Ciuhodaru T.; Matei V.; Nieman D.H.; Sommer I.; van Os J.; van Amelsvoort T.; Sun C.-F.; Guu T.-W.; Jiao C.; Zhang J.; Fan J.; Zou L.; Chi X.; Yu X.; de Timary P.; van Winkel R.; Ng B.; Pena E.; Arellano R.; Roman R.; Sanchez T.; Morgado P.; Brissos S.; Aizberg O.; Mosina A.; Krinitski D.; Mugisha J.; Sadeghi-Bahmani D.; Brand S.; Sheybani F.; Sadeghi M.; Hadi S.; Errázuriz Concha, Antonia; Crossley Karmelic, Nicolás Andrés; Ristic D.I.; Lopez-Jaramillo C.; Kuttichira P.; Kallivayalil R.A.; Javed A.; Afridi M.I.; James B.; Seb-Akahomen O.J.; Daskalakis J.; Yatham L.N.; Yang L.; Okasha T.; Dahdouh A.; Shin J.I.; Lee J.; Mhalla A.; Gaha L.; Brahim T.; Altynbekov K.; Negay N.; Nurmagambetova S.; Jamei Y.A.; Weiser M.The Collaborative Outcome study on Health and Functioning during Infection Times (COH-FIT; www.coh-fit.com) is an anonymous and global online survey measuring health and functioning during the COVID-19 pandemic. The aim of this study was to test concurrently the validity of COH-FIT items and the internal validity of the co-primary outcome, a composite psychopathology “P-score”. Methods: The COH-FIT survey has been translated into 30 languages (two blind forward-translations, consensus, one independent English back-translation, final harmonization). To measure mental health, 1–4 items (“COH-FIT items”) were extracted from validated questionnaires (e.g. Patient Health Questionnaire 9). COH-FIT items measured anxiety, depressive, post-traumatic, obsessive-compulsive, bipolar and psychotic symptoms, as well as stress, sleep and concentration. COH-FIT Items which correlated r ? 0.5 with validated companion questionnaires, were initially retained. A P-score factor structure was then identified from these items using exploratory factor analysis (EFA) and confirmatory factor analyses (CFA) on data split into training and validation sets. Consistency of results across languages, gender and age was assessed. Results: From >150,000 adult responses by May 6th, 2022, a subset of 22,456 completed both COH-FIT items and validated questionnaires. Concurrent validity was consistently demonstrated across different languages for COH-FIT items. CFA confirmed EFA results of five first-order factors (anxiety, depression, post-traumatic, psychotic, psychophysiologic symptoms) and revealed a single second-order factor P-score, with high internal reliability (? = 0.95). Factor structure was consistent across age and sex. Conclusions: COH-FIT is a valid instrument to globally measure mental health during infection times. The P-score is a valid measure of multidimensional mental health.