Browsing by Author "Covarrubias, C."
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- ItemGenetic epidemiology of cholesterol cholelithiasis among Chilean Hispanics, Amerindians, and Maoris(W B SAUNDERS CO-ELSEVIER INC, 1998) Miquel P., Juan Francisco; Covarrubias, C.; Villarroel del Pino, Luis A.; Mingrone, G.; Greco, A. V.; Puglielli, L.; Carvallo, P.; Marshall Rivera, Guillermo; Pino Manresa, Guido del; Nervi, Flavio
- ItemHumoral and cellular response induced by a second booster of an inactivated SARS-CoV-2 vaccine in adults(2022) Melo González, Felipe; Méndez, Constanza; Peñaloza, H.F.; Schultz, B.M.; Piña Iturbe, A.; Ríos, M.; Moreno Tapia, D.; Pereira Sánchez, P.; Leighton, D.; Orellana, C.; Covarrubias, C.; Gálvez, N.M.S.; Soto, J.A.; Duarte, L.F.; Rivera Pérez, D.; Vázquez, Y.; Cabrera, A.; Bustos, S.; Iturriaga, C.; Urzua, M.; Navarrete, M.S.; Rojas, Á.; Fasce, R.; Fernández, J.; Mora, J.; Ramírez, E.; Gaete Argel, A.; Acevedo, M.; Valiente Echeverría, F.; Soto Rifo, R.; Weiskopf, D.; Grifoni, A.; Sette, A.; Zeng, G.; Meng, W.; González Aramundiz, J.V.; González, P.A.; Abarca, K.; Bueno, S.M.; Kalergis, A.M.The SARS-CoV-2 Omicron variant has challenged the control of the COVID-19 pandemic even in highly vaccinated countries. While a second booster of mRNA vaccines improved the immunity against SARS-CoV-2, the humoral and cellular responses induced by a second booster of an inactivated SARS-CoV-2 vaccine have not been studied. In the context of a phase 3 clinical study, we report that a second booster of CoronaVac® increased the neutralizing response against the ancestral virus yet showed poor neutralization against the Omicron variant. Additionally, isolated PBMCs displayed equivalent activation of specific CD4+ T cells and IFN-γ production when stimulated with a mega-pool of peptides derived from the spike protein of the ancestral virus or the Omicron variant. In conclusion, a second booster dose of CoronaVac® does not improve the neutralizing response against the Omicron variant compared with the first booster dose, yet it helps maintaining a robust spike-specific CD4+ T cell response.
- ItemIncidence and prevalence of hepatitis C virus infection in Chile.(2005) González, R.; Soza, A.; Hernández, V.; Pérez, R.M.; Alvarez, M.; Morales, A.; Arellano, M.; Riquelme, A.; Viviani, P.; Covarrubias, C.; Arrese, M.; Miquel, J.F.; Nervi, F.
- ItemSynthesis of nanostructured porous silica coatings on titanium and their cell adhesive and osteogenic differentiation properties(2014) Inzunza, D.; Covarrubias, C.; Marttens, A.; Leighton, Y.; Carvajal C., Jorge A.; Valenzuela, F.; Díaz Dosque, M.; Mendez, N.; Martínez, Constanza; Cáceres, M.; Smith, P.