Browsing by Author "Cifuentes, Marcela"

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    First isolation of kpc in Chile: from Italy to a public hospital in Santiago
    (SOC CHILENA INFECTOLOGIA, 2012) Cifuentes, Marcela; Garcia, Patricia; San Martin, Paola; Silva, Francisco; Zuniga, Jennifer; Reyes, Sergio; Rojas, Rodrigo; Ponce, Rodrigo; Quintanilla, Raul; Delpiano, Luis; Wolff, Marcelo
    Carbapenem resistance in Enterobacteriaceae is an emerging problem worldwide. Among the mechanisms involved are the production of ESBLs or AmpC associated with porins loss or the presence of carbapenemases. Among these, the KPC betalactamase has become especially relevant given its rapid spread.In this article we present the first case of isolation of a strain of KPC producer Klebsiella pneumoniae at a hospital in Santiago, in a patient coming from Italy, with a history of multiple hospitalizations for treatment of non-Hodgkin lymphoma and subjected to several cycles of chemotherapy and hemodialysis. The strain was isolated from a urine culture on the seventh day of the patient's arrival to Chile. The isolate was resistant to quinolones, aminoglycosides, cephalosporins and carbapenems, retaining only susceptibility to tigecycline and colistin. In phenotypic test it was found to have positive Hodge test and positive synergy with carbapenems/boronic acid. Polymerase chain reaction demonstrated the presence of beta-lactamases TEM, SHV and KPC-2. None other Class A serine-carbapenemase or metallo-bectalactamases were present.
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    Grupo Colaborativo de Resistencia Bacteriana, Chile : recomendaciones 2014 para el control de la resistencia bacteriana
    (2015) Cifuentes, Marcela; Silva, Francisco; Arancibia, J. Miguel; Rosales, Ruth; Ajenjo Henríquez, María Cristina; Riedel, Gisela; Camponovo, Rossana; Labarca L., Jaime
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    Incidencia de bacterias multi-resistentes en unidades de cuidados intensivos de hospitales chilenos
    (2017) Paz Acuna, M.; Cifuentes, Marcela; Silva, Francisco; Rojas, Alvaro; Cerda, Jaime; Labarca, Jaime; Grp Colaborativo Resistencia
    Introduction: Incidence of multi-resistant bacteria is an indicator that permits better estimation of the magnitude of bacterial resistance in hospitals. Aim: To evaluate the incidence of relevant multi-drug resistant bacteria in intensive care units (ICUs) of Chile. Methods: Participating hospitals submitted information about the number of isolates from infected or colonized patients with 7 epidemiologically relevant multi-resistant bacteria in adult and pediatric ICUs between January 1, 2014 and October 31, 2015 and the number of bed days occupied in these units in the same period was requested. With these data incidence was calculated per 1,000 patient days for each unit. Results: Information from 20 adults and 9 pediatric ICUs was reviewed. In adult ICUs the bacteria with the highest incidence were K. pneumoniae ESBL [4.72 x 1,000 patient day (1.21-13.89)] and oxacillin-resistant S. aureus [3.85 (0.71-12.66)]. In the pediatric units the incidence was lower, highlighting K. pneumoniae ESBL [2.71 (0-7.11)] and carbapenem-resistant P aeruginosa [1.61 (0.31-9.25)]. Conclusion: Important differences between hospitals in the incidence of these bacteria were observed. Incidence of multi-resistant bacteria in adult ICU was significantly higher than in pediatric ICU for most of the studied bacterias.
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    Presencia del genotipo Beijing entre cepas del complejo mycobacterium tuberculosis en dos centros de salud de la Región Metropolitana-Chile
    (2014) Meza, Paulina; Balcells Marty, María Elvira; Miranda, Carolina; Cifuentes, Marcela; Wozniak Banchero, Aniela; García Cañete, Patricia