Browsing by Author "Cerda, P."

Now showing 1 - 7 of 7
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    Caracterización de las exposiciones a plaguicidas entre los años 2006 y 2013 reportadas al Centro de Información Toxicológica de la Pontificia Universidad Católica de Chile
    (2015) Gutiérrez, W.; Cerda, P.; Plaza Plaza, José Cristián; Mieres, J.; Paris, E.; Ríos Bustamante, Juan Carlos
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    Characterization of the phone-calls made to a poison center related to household and cosmetics products exposition in pediatrics
    (SOC CHILENA PEDIATRIA, 2019) Gonzalez, F.; Retamal, C.; Silva, L.; Cerda, P.; Medel, P.; Solari, S.; Mellado, R.; Rios, J. C.
    Introduction: Household cleaning products and cosmetics are necessary for daily life and widely used by the population. However, their use may not be risk-free, especially when they are not used or stored as recommended. It is important to characterize exposures, as this is useful for developing strategies to reduce morbidity, mortality, and health costs associated, especially in the child population. Objective: To describe reports associated with household cleaning products and cosmetics exposure in patients under the age of 12, reported to the Poison Information Center of the Catholic University of Chile (CITUC). Patients and Method: Descriptive cross-sectional study of phone calls to CITUC during 2016. The analyzed variables were age, sex, product, caller, caller and incident location, exposure circumstances, exposure route(s), symptoms, and severity from manual records and from the WHO's electronic record software 'INTOX Data Management System'. Results: 3,415 cases met the inclusion criteria. Children under the age of five represented 91% of the exposures, and 58.5% were male. 99.4% were accidental exposures, and 98.6% occurred at home. Family members (57%) and health personnel (42%) made the calls. 68.3% of the patients had no symptoms after exposure. The four products with the highest incidence were household bleach (27.6%), floor cleaners and polishers (13.1%), dish soap (7.9%), and perfume/cologne (5.8%). The main exposure route was by ingestion (89.4%). Conclusions: Household cleaning products and cosmetics are common causes of exposures especially in children under the age of five. Although these products have a low morbidity and mortality rate, it is important to educate the population to prevent possible poisonings in the child population.
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    CuratorNet: Visually-aware recommendation of art images
    (2020) Messina, P.; Cartagena, M.; Cerda, P.; del Rio, F.; Parra Santander, Denis Alejandro
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    Exposición a agentes de riesgo biológico en trabajadores Chilenos. Reporte del centro de información toxicológica de la pontificia universidad católica de Chile (CITUC)
    (2014) Cerda, P.; Cortes, S.; Bettini Silva, Marli Francesca; Mieres Araya, Juan José; Paris Mancilla, Oscar Enrique; Ríos Bustamante, Juan Carlos
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    Identification of Generation Expansion Plans in Competitive Markets
    (IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 2011) Cerda, P.; Larrain, M.; Rudnick, H.
    Generation expansion planning plays a key role in the development of a power system. This paper contributes by developing a heuristic based on the results of a simulation model of the Central Interconnected System (SIC), which iteratively optimizes the number of expansion units necessary to accomplish certain assumptions and restrictions that a competitive market must meet in the long term. The first approach is from the theoretical perspective, through a review of the available literature on the subject, and the analysis of the historical development that the generation segment has at SIC, from the private and regulator perspectives. Additionally, a discussion of concepts related to the structure and assumptions that must be met in a competitive market is achieved, allowing the definition of the rules that must be followed by the heuristic. The heuristic uses a model developed by Endesa Chile, called MHT, which simulates the economic dispatch of a hidro-thermal system. The disadvantage of MHT is the massive use of computer resources, employing extensive time to run. Therefore, a number of simplifications on the input data are proposed, to reduce the simulation time; however, they produce significant distortion on the results. The heuristic is applied to a significant number of cases with different initial conditions, demonstrating a satisfactory performance under all the scenarios, which is verified by the fact that investment in new generation capacity reaches the expected levels.
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    Multistate Models: Accurate and Dynamic Methods to Improve Predictions of Thrombotic Risk in Patients with Cancer
    (2019) Carmona-Bayonas, A.; Jimenez-Fonseca, P.; Garrido S., Marcelo; Custodio, A.; Hernandez, R.; Lacalle, A.; Cano, J.M.; Aguado, G.; De Castro, E.M.; Mancenido, F.A.; Macias, I.; Visa, L.; Richard, M.M.; Mangas, M.; Canovas, M.S.; Longo, F.; Rey, L.I.; Lago, N.M.; Carnicero, A.M.; Sanchez, A.; Azkarate, A.; Limon, M.L.; Perez, C.H.; Ramchandani, A.; Pimentel, P.; Cerda, P.; Serrano, R.; Gil-Negrete, A.; Marin, M.; Hurtado, A.; Bayona, R.S.; Gallego, J.
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    Optimal duration of first-line chemotherapy for advanced gastric cancer: data from the AGAMENON registry
    (SPRINGER INTERNATIONAL PUBLISHING AG, 2020) Viudez, A.; Carmona Bayonas, A.; Gallego, J.; Lacalle, A.; Hernandez, R.; Cano, J. M.; Macias, I; Custodio, A.; Martinez de Castro, E.; Sanchez, A.; Iglesia, L.; Reguera, P.; Visa, L.; Azkarate, A.; Sanchez Canovas, M.; Mangas, M.; Limon, M. L.; Martinez Torron, A.; Asensio, E.; Ramchandani, A.; Martin Carnicero, A.; Hurtado, A.; Cerda, P.; Garrido, M.; Sanchez Bayonas, R.; Serrano, R.; Jimenez Fonseca, P.; AGAMENON Study Grp
    Background The optimal duration of first-line chemotherapy for patients with advanced gastric cancer is unknown. Diverse clinical trials have proposed different strategies including limited treatment, maintenance of some drugs, or treatment until progression. Method The sample comprises patients from the AGAMENON multicenter registry without progression after second evaluation of response. The objective was to explore the optimal duration of first-line chemotherapy. A frailty multi-state model was conducted. Results 415 patients were divided into three strata: discontinuation of platinum and maintenance with fluoropyrimidine until progression (30%, n = 123), complete treatment withdrawal prior to progression (52%, n = 216), and full treatment until progression (18%, n = 76). The hazard of tumor progression decreased by 19% per month with the full treatment regimen. However, we found no evidence that fluoropyrimidine maintenance (hazard ratio [HR] 1.07, confidence interval [CI] 95%, 0.69-1.65) worsened progression-free survival (PFS) with respect to treatment until progression. Predictive factors for PFS were ECOG performance status, >= 3 metastatic sites, prior tumor response, and bone metastases. Toxicity grade 3/4 was more common in those who continued the full treatment until progression vs fluoropyrimidine maintenance (16% vs 6%). Conclusion The longer duration of the full initial regimen exerted a protective effect on the patients of this registry. Platinum discontinuation followed by fluoropyrimidine maintenance yields comparable efficacy to treatment up to PD, with a lower rate of serious adverse events.