Browsing by Author "Celis Morales, Carlos"

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    Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena
    (2018) Petermann, Fanny; Villagrán, Marcelo; Troncoso, Claudia; Mardones, Lorena; Leiva, Ana María; MartÍnez, María Adela; Garrido Méndez, Alex; Poblete Valderrama, Felipe; Salas Bravo, Carlos; Ramírez Vélez, Robinson; Ulloa, Natalia; Pérez Bravo, Francisco; Celis Morales, Carlos
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    Associations of six adiposity-related markers with incidence and mortality from 24 cancers—findings from the UK Biobank prospective cohort study
    (2021) Parra Soto, Solange; Ferreccio Readi, Catterina; Cowley, Emma S.; Rezende, Leandro F. M.; Mathers, John C.; Pell, Jill P.; Ho, Frederick K.; Celis Morales, Carlos
    Abstract Background Adiposity is a strong risk factor for cancer incidence and mortality. However, most of the evidence available has focused on body mass index (BMI) as a marker of adiposity. There is limited evidence on relationships of cancer with other adiposity markers, and if these associations are linear or not. The aim of this study was to investigate the associations of six adiposity markers with incidence and mortality from 24 cancers by accounting for potential non-linear associations. Methods A total of 437,393 participants (53.8% women; mean age 56.3 years) from the UK Biobank prospective cohort study were included in this study. The median follow-up was 8.8 years (interquartile range 7.9 to 9.6) for mortality and 9.3 years (IQR 8.6 to 9.9) for cancer incidence. Adiposity-related exposures were BMI, body fat percentage, waist-hip ratio, waist-height ratio, and waist and hip circumference. Incidence and mortality of 24 cancers sites were the outcomes. Cox proportional hazard models were used with each of the exposure variables fitted separately on penalised cubic splines. Results During follow-up, 47,882 individuals developed cancer and 11,265 died due to cancer during the follow-up period. All adiposity markers had similar associations with overall cancer incidence. BMI was associated with a higher incidence of 10 cancers (stomach cardia (hazard ratio per 1 SD increment 1.35, (95% CI 1.23; 1.47)), gallbladder (1.33 (1.12; 1.58)), liver (1.27 (1.19; 1.36)), kidney (1.26 (1.20; 1.33)), pancreas (1.12 (1.06; 1.19)), bladder (1.09 (1.04; 1.14)), colorectal (1.10 (1.06; 1.13)), endometrial (1.73 (1.65; 1.82)), uterine (1.68 (1.60; 1.75)), and breast cancer (1.08 (1.05; 1.11))) and overall cancer (1.03 (1.02; 1.04)). All these associations were linear except for breast cancer in postmenopausal women. Similar results were observed when other markers of central and overall adiposity were used. For mortality, nine cancer sites were linearly associated with BMI and eight with waist circumference and body fat percentage. Conclusion Adiposity, regardless of the marker used, was associated with an increased risk in 10 cancer sites.
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    Prevalencia de síndrome metabólico en individuos de etnia Mapuche residentes en zonas rurales y urbanas de Chile
    (2014) Ibáñez Anrique, Luis; Sanzana, Ruth; Salas, Carlos; Navarrete, Claudia; Cartes Velásquez, Ricardo; Rainqueo, Angélica; Jara, Tamara; Pérez Bravo, Francisco; Ulloa, Natalia; Miquel P., Juan Francisco; Calvo Miranda, Carlos; Celis Morales, Carlos
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    Respuestas metabólicas inducidas por ejercicio físico de alta intensidad en mujeres sedentarias con glicemia basal alterada e hipercolesterolemia
    (2013) Álvarez L., Cristián; Ramírez-Campillo, Rodrigo; Flores O., Marcelo; Henríquez Olguín, Carlos; Campos Jara, Christian Alex; Carrasco, Vanesa; Martínez S., Cristian; Celis Morales, Carlos