Browsing by Author "Caussade, Solange"

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    Exercise Challenge Test: Is a 15% Fall in FEV1 Sufficient for Diagnosis?
    (2011) Fuentes, Claudia; Contreras, Stefani; Padilla, Oslando; Castro-Rodriguez, Jose A.; Moya, Ana; Caussade, Solange
    Introduction. In the exercise challenge test (ECT), a drop in forced expiratory volume in the first second (FEV1) of between 10 and 15% is the determinant variable for a diagnosis of exercise-induced bronchospasm. Hypothesis. The use of FEV1 plus mean forced expiratory flow between 25% and 75% of the forced vital capacity (FEF25-75%) may increase the sensitivity of the ECT in asthmatic children. Specific objective. To compare FEV1 and FEF25-75% changes in a group of asthmatic and healthy children. Methodology. This was a cross-sectional study. Asthmatics were categorized by their severity (GINA) and after 1 month without controller therapy, an ECT was done under standard protocol. As well, a questionnaire about rhinitis and asthma was conducted with the entire population. ROC curves were used for analysis. Results. A total of 147 children (34 healthy and 113 asthmatics, 18 and 58 males, respectively) were evaluated. Divided into healthy children and intermittent, mild and moderate persistent asthmatics, they had similar average ages (9.4, 9.48, 8.97, and 11.2 years, respectively). Using a 15% fall in FEV1, we obtained 29% sensitivity and 100% specificity. However, when we used a 10% fall in FEV1, sensitivity was 47% and specificity was 97%. Adding a 28% fall in FEF25-75%, sensitivity was 52% and specificity was 94%. Conclusion. This study suggests that test sensitivity can increase by using a lower FEV1 cut-off (10%) and adding a 28% fall in FEF25-75%.
  • Thumbnail Image
    Item
    Spirometric values in healthy Chilean children and adolescents
    (SOC MEDICA SANTIAGO, 2015) Caussade, Solange; Contreras, Ilse; Villarroel, Luis; Fierro, Laura; Sanchez, Ignacio; Bertrand, Pablo; Holmgren, Nils L.
    Background: Spirometric flow and volume measurement are essential to evaluate patients with pulmonary disease. In Chile, several reference equations are used. Aim: To measure flow and expiratory volumes in healthy children and adolescents and compare their results with theoretical values according to Knudson, Quanjer, Gutierrez and NANHES III. Subjects and Methods: Spirometries were performed according to international standards in 1589 healthy children and adolescents aged 6 to 18 years (861 females) who lived in Santiago, Chile. Results: The obtained values for forced vital capacity, expiratory volume in one second, peak expiratory flow, were significantly higher than those calculated according to the above mentioned standards (p < 0.0001) with differences up to 18.7%. We constructed reference formulas for ages ranging from 6 to 18 years, separated by gender, using age, weight and height as independent variables. The latter had the greater influence on formula construction. Conclusions: The use of these new local formulas with allow the correct interpretation of spirometric results obtained in Chilean children and adolescents.
  • Thumbnail Image
    Item
    Valores de Oximetría de Pulso en Prematuros a las 34-36 semanas post-concepcional
    (2023) Oyarzun Aguirre, Ignacio Javier; Díaz, Marcela; Toso Milos, Paulina Alejandra; Zamorano Wittwer, Alejandra Violeta; Montes, Soledad; Lindemann, Birthe C.; Caussade, Solange
    La oximetría de pulso (SpO2) es fundamental para orientar la oxigenoterapia en prematuros. Existen escasas publicaciones que muestren valores de SpO2 previo al alta. Objetivo: Obtener valores de SpO2 en prematuros asintomáticos a las 34, 35 y 36 semanas post-concepcionales. Sujetos y Método: Estudio longitudinal multicéntrico realizado entre mayo 2018 y mayo 2019, en tres unidades de neonatología de Santiago, Chile (altura 579 m). Se incluyeron recién nacidos ≤ 32 semanas de edad gestacional, clínicamente estables, sin morbilidad respiratoria al momento de la evaluación y hasta el alta. Se analizaron los siguientes parámetros: SpO2 y DS acumulados medios, valor mínimo de SpO2, porcentaje de tiempo de SpO2 < 90%, porcentaje de tiempo de SpO2 < 80%, ID4 e ID80. Se obtuvo SpO2 continua nocturna con oxímetro Masimo Radical-7 o Radical-8 (USA), tiempo válido de registro (TVR) ≥ 6 horas. Resultados: se obtuvieron 101 registros de SpO2: 44, 33 y 24 estudios a las 34, 35 y 36 semanas post-concepcionales respectivamente. Estos pertenecían a 62 prematuros, 28 (45%) varones, mediana (rango) de edad gestacional al nacer 30 (26-32) semanas, mediana (rango) peso al nacer 1480 (785-2700) g. Variables de oximetría: TVR, media (± DE) 8,6 (± 1,5) horas; SpO2 promedio, mediana (rango) 96,9% (93,3-99,3%); SpO2 mínima, mediana (rango) 74% (51-89%); tiempo de SpO2 < 90%, mediana (rango) 2% (0-10,6%); tiempo de SpO2 < 80%, mediana (rango) 0,1% (0-1,3%); evento de desaturación ≥ 4% (ID4) ≥ 10 segundos por hora muestreada, mediana (rango) 15 (3,5–62,5); evento de desaturación < 80% (ID80), mediana (rango) 0,58 (0-10,8). No hubo diferencias entre valores de SpO2 entre las distintas semanas post-concepcionales. Conclusiones: Describimos valores de SpO2 en prematuros extremos asintomáticos a las 34-36 semanas postconcepcionales. Estos valores podrían utilizarse como referencia para orientar oxigenoterapia.