Browsing by Author "Castro G P."
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- ItemOxidative stress and inflammation in heart failure: Mechanisms of damage and therapeutic alternativesEstrés oxidativo e inflamación en insuficiencia cardiaca: Mecanismos de daño y alternativas terapéuticas(2007) Miranda H R.; Castro G P.; Verdejo P H.; Chiong M.; Díaz-Araya G.; Mellado R.; Rojas D.; Lavandero S.; Concepción R.; Castro G P.; Lavandero S.Despite advances in treatment, chronic heart failure still is associated with a poor prognosis and remains a leading cause of cardiovascular death. Cumulating evidence suggests that imbalances in redox state lead to a higher generation of reactive oxygen species. This phenomenon, along with pro-inflammatory cytokine activation and extra cellular matrix alterations with reactive fibrosis, play an important role in the pathogenesis and progression of heart failure, through the development of endothelial and myocardial dysfunction. The understanding of the underlying phenomena and the metabolic pathways involved will allow further development of therapies aiming to change the natural history of heart failure.
- ItemPredictors of hospital death and prolonged hospitalization in patients with cardiac failure in Chilean hospitalsPredictores de mortalidad intrahospitalaria y hospitalización prolongada en la insuficiencia cardíaca: Resultados preliminares del registro nacional de insuficiencia cardíaca. Grupo ICARO(2006) Castro G P.; Verdejo P H.; Vukasovic R J.L.; Garcés E.; Ilse González D E.U.; Castro G P.; Kauffmann R.; Echeverría C.; Montes E.U.A.; Mercadal E.; Pacheco C.; Garcés E.; Eggers G.; Muñoz E.U.P.; Venegas J.; Castro P.; Marchant E.U.M.; Sepúlveda L.; Vukasovic J.L.; Rossel V.; Soto J.R.; Venegas C.; Yovaniniz P.; Cárdenas F.; Saavedra M.; Lanas F.; Araneda G.Background: Heart failure (HF) is one of the most common causes for hospital admission. Aim: To evaluate clinical predictors of mortality and prolonged hospital stay among patients admitted for HF in Chilean hospitals. Patients and Methods: Prospective registry of 14 centers. Patients admitted for HF in functional class III and IV were included. Epidemiological, clinical data, functional class, decompensation cause, electrocardiogram, echocardiogram, treatment and evolution were registered. The endpoint was hospital death and hospital stay greater than 10 days. Results: Data from 646 patients (mean age 69±13 years, 56% men) was collected. The main etiologies of HF were hypertensive in 29.6%, ischemic in 27.1% and valvular in 20%. Mean hospital stay was 10±9 days and mortality was 5.6%. Independent predictors of death and prolonged hospital stay were serum sodium <130 mEq/L at admission (odds ratio (OR) 2.6, confidence interval (CI)= 1.2-5.9), serum albumin <3 g/dL (OR 3.2, CI= 1.42-7.2) and a history of hypertension (OR 1.98, CI=1.1-3.85). The model predicted correctly the occurrence of the endpoint in 67% of cases. Conclusions: In patients admitted for worsening HF, low serum sodium, decreased serum albumin on admission and a history of hypertension increase the risk for in-hospital death and prolonged hospital stay. © 2006 Sociedad Médica de Santiago.