Browsing by Author "Carvajal, Jorge"

Now showing 1 - 3 of 3
  • Thumbnail Image
    Item
    Frequency of subclinical thyroid problems among women during the first trimester of pregnancy
    (SOC MEDICA SANTIAGO, 2012) Mosso M, Lorena; Martinez G, Alejandra; Paulina Rojas, Maria; Margozzini, Paula; Solari, Sandra; Lyng, Trinidad; Andres Ortiz, Juan; Carvajal, Jorge
    Background: Thyroid hormones play an important role in fetal neural and cognitive development. Therefore thyroid abnormalities should be detected and treated early during pregnancy. Aim: To assess the frequency and risk factors for functional thyroid disorders during the first trimester of pregnancy. Material and Methods: A blood sample was obtained from women during their first trimester of pregnancy, consulting in a prenatal care facility. Women with known thyroid diseases were excluded from the study. Thyroid stimulating hormone (TSH), total thyroxine (T4) and free thyroxine (fT4) were measured by electrochemoluminiscence. Antithyroid peroxidase antibodies (anti TPO) were measured by enzyme immunoassay. Results: Five hundred and ten women aged 25.7 +/- 6.6 years were assessed. The frequency of clinical hypothyroidism was 0.6%, subclinical hypothyroidism 35.3% and clinical hyperthyroidism 1%. Five percent of women with hypothyroidism and 3.5% of euthyroid women had positive anti TPO antibodies. There was no association between the frequency of thyroid diseases and risk factors for thyroid diseases. Conclusions: There is a high frequency of subclinical thyroid diseases among women consulting in this prenatal care clinic. (Rev Med Chile 2012; 140: 1401-1408).
  • Thumbnail Image
    Item
    Functional consequences of SARS-CoV-2 infection in pregnant women, fetoplacental unit, and neonate
    (ELSEVIER, 2023) Carvajal, Jorge; Casanello, Paola; Toso, Alberto; Farias, Marcelo; Carrasco-Negue, Karina; Araujo, Kenny; Valero, Paola; Fuenzalida, Javiera; Solari, Caterina; Sobrevia, Luis
    The SARS-CoV-2 infection causes COVID-19 disease, characterized by acute respiratory distress syndrome, bilateral pneumonia, and organ failure. The consequences of maternal SARS-CoV-2 infection for the pregnant woman, fetus, and neonate are controversial. Thus, it is required to determine whether there is viral and non -viral vertical transmission in COVID-19. The disease caused by SARS-CoV-2 leads to functional alterations in asymptomatic and symptomatic pregnant women, the fetoplacental unit and the neonate. Several diseases of pregnancy, including COVID-19, affect the fetoplacental function, which causes in utero programming for young and adult diseases. A generalized inflammatory state and a higher risk of infection are seen in pregnant women with COVID-19. Obesity, diabetes mellitus, and hypertension may increase the vulnerability of pregnant women to infection by SARS-CoV-2. Alpha, Delta, and Omicron variants of SARS-CoV-2 show specific mutations that seem to increase the capacity of the virus to infect the pregnant woman, likely due to increasing its interaction via the virus S protein and angiotensin-converting enzyme 2 receptors. This review shows the literature addressing to what extent COVID-19 in pregnancy affects the pregnant woman, fetoplacental unit, and neonate. Prospective studies that are key in managing SARS-CoV-2 infection in pregnancy are discussed.
  • No Thumbnail Available
    Item
    Maternal outcomes and risk factors for COVID-19 severity among pregnant women
    (2021) Vouga, Manon; Favre, Guillaume; Pomar, Leo; Forcen Acebal, Laura; Abascal-Saiz, Alejandra; Vila Hernandez, Maria Rosa; Hcini, Najeh; Lambert, Veronique; Carles, Gabriel; Sichitiu, Joanna; Salomon, Laurent; Stirnemann, Julien; Ville, Yves; de Tejada, Begona Martinez; Gonce, Anna; Castillo, Karen; Gratacos Solsona, Eduard; Trigo, Lucas; Cleary, Brian; Geary, Michael; Bartels, Helena; Malone, Fergal; Higgins, Mary; Keating, Niamh; Knowles, Susan; Poncelet, Christophe; Surita, Fernanda; Borrelli, Carolina; Luz, Adriana Gomes; Fuenzalida, Javiera; Carvajal, Jorge; Guerra Canales, Manuel; Hernandez, Olivia; Grechukhina, Olga; Ko, Albert, I; Reddy, Uma; Figueiredo, Rita; Moucho, Marina; Pinto, PedroViana; De Luca, Carmen; De Santis, Marco; de Campos, Diogo Ayres; Martins, Ines; Garabedian, Charles; Subtil, Damien; Bohrer, Betania; Da Rocha Oppermann, Maria Lucia; OsorioWender, Maria Celeste; Vieira Sanseverino, Maria Teresa; Giugliani, Camila; Friedrich, Luciana; Scherer, Mariana Horn; Mottet, Nicolas; Ducarme, Guillaume; Pelerin, Helene; Moreau, Chloe; Breton, Benedicte; Quibel, Thibaud; Rozenberg, Patrick; Giannoni, Eric; Granado, Cristina; Monod, Cecile; Mueller, Doris; Hoesli, Irene; Bassler, Dirk; Heldstab, Sandra; Kolble, Nicole Ochsenbein; Sentilhes, Loic; Charvet, Melissa; Deprest, Jan; Richter, Jute; Van der Veeken, Lennart; Eggel-Hort, Beatrice; Plantefeve, Gaetan; Derouich, Mohamed; Nieto Calvache, Albaro Jose; Hecher, Kurt; Hadar, Eran; Haratz, Karina Krajden; Amikam, Uri; Malinger, Gustavo; Maymon, Ron; Yogev, Yariv; Schafer, Leonhard; Toussaint, Arnaud; Rossier, Marie-Claude; De Sa, RenatoAugusto Moreira; Grawe, Claudia; Aebi-Popp, Karoline; Raio, Luigi; Surbek, Daniel; Bockenhof, Paul; Strizek, Brigitte; Kaufmann, Martin; Bloch, Andrea; Boulvain, Michel; Johann, Silke; Heldstab, SandraAndrea; Bernasconi, MonyaTodesco; Grant, Gaston; Feki, Anis; Muller Brochut, Anne-Claude; Giral, Marylene; Sedille, Lucie; Papadia, Andrea; Brugger, Romina Capoccia; Weber, Brigitte; Fischer, Tina; Kahlert, Christian; Saines, Karin Nielsen; Cambou, Mary; Kanellos, Panagiotis; Chen, Xiang; Yin, Mingzhu; Haessig, Annina; Ackermann, Sandrine; Baud, David; Panchaud, Alice
    Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n=53/75)], preterm delivery [62.7% (n=32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n=31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease.