Browsing by Author "Cantillano Malone, Christian"

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    Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS)
    (2024) Weil, Alexander G.; Dimentberg, Evan; Lewis, Evan; Ibrahim, George M.; Kola, Olivia; Tseng, Chi-Hong; Chen, Jia-Shu; Lin, Kao-Min; Cai, Li-Xin; Liu, Qing-Zhu; Lin, Jiu-Luan; Zhou, Wen-Jing; Mathern, Gary W.; Smyth, Matthew D.; O'Neill, Brent R.; Dudley, Roy; Ragheb, John; Bhatia, Sanjiv; Delev, Daniel; Ramantani, Georgia; Zentner, Josef; Wang, Anthony C.; Dorfer, Christian; Feucht, Martha; Czech, Thomas; Bollo, Robert J.; Issabekov, Galymzhan; Zhu, Hongwei; Connolly, Mary; Steinbok, Paul; Zhang, Jian-Guo; Zhang, Kai; Hidalgo, Eveline Teresa; Weiner, Howard L.; Wong-Kisiel, Lily; Lapalme-Remis, Samuel; Tripathi, Manjari; Sarat Chandra, Poodipedi; Hader, Walter; Wang, Feng-Peng; Yao, Yi; Champagne, Pierre Olivier; Brunette-Clement, Tristan; Guo, Qiang; Li, Shao-Chun; Budke, Marcelo; Perez-Jimenez, Maria Angeles; Raftopoulos, Christian; Finet, Patrice; Michel, Pauline; Schaller, Karl; Stienen, Martin N.; Baro, Valentina; Cantillano Malone, Christian; Pociecha, Juan; Chamorro, Noelia; Muro, Valeria L.; von Lehe, Marec; Vieker, Silvia; Oluigbo, Chima; Gaillard, William D.; Al Khateeb, Mashael; Al Otaibi, Faisal; Krayenbuhl, Niklaus; Bolton, Jeffrey; Pearl, Phillip L.; Fallah, Aria
    ObjectivesAlthough hemispheric surgeries are among the most effective procedures for drug-resistant epilepsy (DRE) in the pediatric population, there is a large variability in seizure outcomes at the group level. A recently developed HOPS score provides individualized estimation of likelihood of seizure freedom to complement clinical judgement. The objective of this study was to develop a freely accessible online calculator that accurately predicts the probability of seizure freedom for any patient at 1-, 2-, and 5-years post-hemispherectomy.MethodsRetrospective data of all pediatric patients with DRE and seizure outcome data from the original Hemispherectomy Outcome Prediction Scale (HOPS) study were included. The primary outcome of interest was time-to-seizure recurrence. A multivariate Cox proportional-hazards regression model was developed to predict the likelihood of post-hemispheric surgery seizure freedom at three time points (1-, 2- and 5- years) based on a combination of variables identified by clinical judgment and inferential statistics predictive of the primary outcome. The final model from this study was encoded in a publicly accessible online calculator on the International Network for Epilepsy Surgery and Treatment (iNEST) website ().ResultsThe selected variables for inclusion in the final model included the five original HOPS variables (age at seizure onset, etiologic substrate, seizure semiology, prior non-hemispheric resective surgery, and contralateral fluorodeoxyglucose-positron emission tomography [FDG-PET] hypometabolism) and three additional variables (age at surgery, history of infantile spasms, and magnetic resonance imaging [MRI] lesion). Predictors of shorter time-to-seizure recurrence included younger age at seizure onset, prior resective surgery, generalized seizure semiology, FDG-PET hypometabolism contralateral to the side of surgery, contralateral MRI lesion, non-lesional MRI, non-stroke etiologies, and a history of infantile spasms. The area under the curve (AUC) of the final model was 73.0%.SignificanceOnline calculators are useful, cost-free tools that can assist physicians in risk estimation and inform joint decision-making processes with patients and families, potentially leading to greater satisfaction. Although the HOPS data was validated in the original analysis, the authors encourage external validation of this new calculator.
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    Guillain-Barre Syndrome and Hydrocephalus in an infant with Wiskott-Aldrich Syndrome
    (SOC CHILENA PEDIATRIA, 2020) Avila Smirnow, Daniela; Cordova Aguilera, Marcela; Cantillano Malone, Christian; Arriaza Ortiz, Manuel; Wegner Araya, Adriana
    Guillain-Barre Syndrome (GBS) is rarely diagnosed in the first year of life. The association of GBS with Wiskott-Aldrich syndrome (WAS) is even less frequent and has been previously reported in only two children to our knowledge. Hydrocephalus is a known but rare complication of GBS. Objective: To describe the case of an infant in which GBS, WAS and hydrocephalus appear clinically associated. Clinical Case: A nine-months-old male infant with a history of WAS was admitted to our ICU with acute hypotonia and poor general condition. He developed flaccid paralysis, absent deep tendon reflexes, and respiratory failure. A lumbar puncture showed albuminocytologic dissociation. GBS was suspected and an electromyography was performed, showing a demyelinating polyneuropathy. He was successfully treated with intravenous immunoglobulins. During hospitalization, he presented intermittent bradycardia, so a brain CT scan was performed, showing acute hydrocephalus which was managed through an external ventricular drain achieving favorable response. In the long term, the patient underwent bone marrow transplant and had to be reoperated due to valve-related complications. However, his psychomotor development is normal, with no obvious neurological sequelae. Conclusion: We present the third case of GBS in a patient with WAS, which is the first infant younger than one year. Additionally, he presented acute hydrocephalus as a complication of GBS. We suggest considering these three comorbidities since their early diagnosis and prompt management allow better neurological recovery and avoid potentially lethal complications.
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    Hemispherectomy Outcome Prediction Scale: Development and validation of a seizure freedom prediction tool
    (2021) Weil, Alexander G.; Lewis, Evan C.; Ibrahim, George M.; Kola, Olivia; Tseng, Chi-Hong; Zhou, Xinkai; Lin, Kao-Min; Cai, Li-Xin; Liu, Qing-Zhu; Lin, Jiu-Luan; Zhou, Wen-Jing; Mathern, Gary W.; Smyth, Matthew D.; O'Neill, Brent R.; Dudley, Roy; Ragheb, John; Bhatia, Sanjiv; Delev, Daniel; Ramantani, Georgia; Zentner, Josef; Ojemann, Jeffrey; Wang, Anthony C.; Dorfer, Christian; Feucht, Martha; Czech, Thomas; Bollo, Robert J.; Issabekov, Galymzhan; Zhu, Hongwei; Connelly, Mary; Steinbok, Paul; Zhang, Jian-Guo; Zhang, Kai; Hidalgo, Eveline Teresa; Weiner, Howard L.; Wong-Kisiel, Lily; Lapalme-Remis, Samuel; Tripathi, Manjari; Sarat Chandra, Poodipedi; Hader, Walter; Wang, Feng-Peng; Yao, Yi; Olivier Champagne, Pierre; Guo, Qiang; Li, Shao-Chun; Budke, Marcelo; Perez-Jimenez, Maria Angeles; Raftapoulos, Christian; Finet, Patrice; Michel, Pauline; Schaller, Karl; Stienen, Martin N.; Baro, Valentina; Cantillano Malone, Christian; Pociecha, Juan; Chamorro, Noelia; Muro, Valeria L.; von Lehe, Marec; Vieker, Silvia; Oluigbo, Chima; Gaillard, William D.; Al Khateeb, Mashael; Al Otaibi, Faisal; Krayenbuhl, Niklaus; Bolton, Jeffrey; Pearl, Phillip L.; Fallah, Aria
    Objective To develop and validate a model to predict seizure freedom in children undergoing cerebral hemispheric surgery for the treatment of drug-resistant epilepsy.