Browsing by Author "Caceres, M."

Now showing 1 - 5 of 5
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    Building arguments: key to collaborative scaffolding
    (2018) Caceres, M.; Nussbaum Voehl, Miguel; Marroquin, M.; Gleisner, S.; Marquinez, J. T.
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    Gingival Wound Healing: An Essential Response Disturbed by Aging?
    (2015) Smith, P. C.; Caceres, M.; Martinez, C.; Oyarzun, A.; Martinez, J.
    Gingival wound healing comprises a series of sequential responses that allow the closure of breaches in the masticatory mucosa. This process is of critical importance to prevent the invasion of microbes or other agents into tissues, avoiding the establishment of a chronic infection. Wound healing may also play an important role during cell and tissue reaction to long-term injury, as it may occur during inflammatory responses and cancer. Recent experimental data have shown that gingival wound healing is severely affected by the aging process. These defects may alter distinct phases of the wound-healing process, including epithelial migration, granulation tissue formation, and tissue remodeling. The cellular and molecular defects that may explain these deficiencies include several biological responses such as an increased inflammatory response, altered integrin signaling, reduced growth factor activity, decreased cell proliferation, diminished angiogenesis, reduced collagen synthesis, augmented collagen remodeling, and deterioration of the proliferative and differentiation potential of stem cells. In this review, we explore the cellular and molecular basis of these defects and their possible clinical implications.
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    Involvement of MT1-MMP and TIMP-2 in human periodontal disease
    (WILEY, 2010) Oyarzun, A.; Arancibia, R.; Hidalgo, R.; Penafiel, C.; Caceres, M.; Gonzalez, M J; Martinez, J.; Smith, P. C.
    Objectives:
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    Simvastatin alters fibroblastic cell responses involved in tissue repair
    (WILEY-BLACKWELL, 2011) Caceres, M.; Romero, A.; Copaja, M.; Diaz Araya, G.; Martinez, J.; Smith, P. C.
    Background and Objective: Statins have been used to control hypercholesterolemia. However, these drugs also exert pleiotropic effects that include the modulation of inflammation and cell signaling. The present study has analyzed the effects of simvastatin on several cell responses involved in tissue repair, including cell adhesion, cell migration and invasion, actin cytoskeleton remodeling and cell viability.
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    Triclosan inhibits tumor necrosis factor-alpha-stimulated urokinase production in human gingival fibroblasts
    (WILEY, 2009) Arancibia, R.; Caceres, M.; Martinez, J.; Smith, P. C.
    Background and Objectives: Destruction of the supporting periodontal tissues is mediated by the action of several proteolytic enzymes. Urokinase is a serine protease that plays a key role in connective tissue destruction through conversion of plasminogen into plasmin. The present study was conducted to evaluate the effect of triclosan on the production and activity of urokinase in cultured gingival fibroblasts.