Browsing by Author "Bustin, Aurélien"
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- Item3D Cartesian fast interrupted steady-state (FISS) imaging(2019) Küstner, Thomas; Bustin, Aurélien; Jaubert, Olivier; Neji, Radhouene; Prieto Vásquez, Claudia; Botnar, René Michael
- Item3D SASHA myocardial T1 mapping with high accuracy and improved precision(2019) Nordio, Giovanna; Bustin, Aurélien; Henningsson, Markus; Rashid, Imran; Chiribiri, Amedeo; Ismail, Tevfik; Odille, Freddy; Prieto Vásquez, Claudia; Botnar, René Michael
- ItemClinical comparison of sub-mm high-resolution non-contrast coronary CMR angiography against coronary CT angiography in patients with low-intermediate risk of coronary artery disease: a single center trial(2021) Hajhosseiny, R.; Rashid, Imran; Bustin, Aurélien; Munoz, Camila; Cruz, Gastao; Nazir, Muhummad Sohaib; Grigoryan, Karine; Ismail, Tevfk F.; Prieto Vásquez, Claudia; Botnar, René MichaelAbstract Background The widespread clinical application of coronary cardiovascular magnetic resonance (CMR) angiography (CMRA) for the assessment of coronary artery disease (CAD) remains limited due to low scan efficiency leading to prolonged and unpredictable acquisition times; low spatial-resolution; and residual respiratory motion artefacts resulting in limited image quality. To overcome these limitations, we have integrated highly undersampled acquisitions with image-based navigators and non-rigid motion correction to enable high resolution (sub-1 mm3) free-breathing, contrast-free 3D whole-heart coronary CMRA with 100% respiratory scan efficiency in a clinically feasible and predictable acquisition time. Objectives To evaluate the diagnostic performance of this coronary CMRA framework against coronary computed tomography angiography (CTA) in patients with suspected CAD. Methods Consecutive patients (n = 50) with suspected CAD were examined on a 1.5T CMR scanner. We compared the diagnostic accuracy of coronary CMRA against coronary CTA for detecting a ≥ 50% reduction in luminal diameter. Results The 50 recruited patients (55 ± 9 years, 33 male) completed coronary CMRA in 10.7 ± 1.4 min. Twelve (24%) had significant CAD on coronary CTA. Coronary CMRA obtained diagnostic image quality in 95% of all, 97% of proximal, 97% of middle and 90% of distal coronary segments. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy were: per patient (100%, 74%, 55%, 100% and 80%), per vessel (81%, 88%, 46%, 97% and 88%) and per segment (76%, 95%, 44%, 99% and 94%) respectively. Conclusions The high diagnostic image quality and diagnostic performance of coronary CMRA compared against coronary CTA demonstrates the potential of coronary CMRA as a robust and safe non-invasive alternative for excluding significant disease in patients at low-intermediate risk of CAD.
- ItemFree-running 3D whole heart myocardial T-1 mapping with isotropic spatial resolution(2019) Qi, Haikun; Jaubert, Olivier; Bustin, Aurélien; Cruz, Gastao; Chen, Huijun; Botnar, René Michael; Prieto Vásquez, Claudia
- ItemFree-running simultaneous myocardial T1/T2 mapping and cine imaging with 3D whole-heart coverage and isotropic spatial resolution(2019) Qi, Haikun; Bustin, Aurélien; Cruz, Gastao; Jaubert, Olivier; Chen, Huijun; Botnar, René Michael; Prieto Vásquez, Claudia
- ItemHigh-resolution non-contrast free-breathing coronary cardiovascular magnetic resonance angiography for detection of coronary artery disease : validation against invasive coronary angiography(2022) Nazir, Muhummad S.; Bustin, Aurélien; Hajhosseiny, Reza; Yazdani, Momina; Ryan, Matthew; Vergani, Vittoria; Neji, Radhouene; Kunze, Karl P.; Perera, Divaka; Botnar, René Michael; Prieto Vásquez, ClaudiaCoronary artery disease (CAD) is the single most common cause of death worldwide. Recent technological developments with coronary cardiovascular magnetic resonance angiography (CCMRA) allow high-resolution free-breathing imaging of the coronary arteries at submillimeter resolution without contrast in a predictable scan time of ~ 10 min. The objective of this study was to determine the diagnostic accuracy of high-resolution CCMRA for CAD detection against the gold standard of invasive coronary angiography (ICA). Methods: Forty-five patients (15 female, 62 ± 10 years) with suspected CAD underwent sub-millimeter-resolution (0.6 mm3) non-contrast CCMRA at 1.5T in this prospective clinical study from 2019–2020. Prior to CCMR, patients were given an intravenous beta blockers to optimize heart rate control and sublingual glyceryl trinitrate to promote coronary vasodilation. Obstructive CAD was defined by lesions with ≥ 50% stenosis by quantitative coronary angiography on ICA. Results: The mean duration of image acquisition was 10.4 ± 2.1 min. On a per patient analysis, the sensitivity, specificity, positive predictive value and negative predictive value (95% confidence intervals) were 95% (75–100), 54% (36–71), 60% (42–75) and 93% (70–100), respectively. On a per vessel analysis the sensitivity, specificity, positive predictive value and negative predictive value (95% confidence intervals) were 80% (63–91), 83% (77–88), 49% (36–63) and 95% (90–98), respectively. Conclusion: As an important step towards clinical translation, we demonstrated a good diagnostic accuracy for CAD detection using high-resolution CCMRA, with high sensitivity and negative predictive value. The positive predictive value is moderate, and combination with CMR stress perfusion may improve the diagnostic accuracy. Future multicenter evaluation is now required
- ItemHigh-Spatial-Resolution 3D Whole-Heart MRI T2 Mapping for Assessment of Myocarditis(2021) Bustin, Aurélien; Hua, Alina; Milotta, Giorgia; Jaubert, Olivier; Hajhosseiny, Reza; Ismail, Tevfik F.; Botnar, René Michael; Prieto Vásquez, ClaudiaBackground: Clinical guidelines recommend the use of established T2 mapping sequences to detect and quantify myocarditis and edema, but T2 mapping is performed in two dimensions with limited coverage and repetitive breath holds.Purpose:To assess the reproducibility of an accelerated free-breathing three-dimensional (3D) whole-heart T2 MRI mapping se-quence in phantoms and participants without a history of cardiac disease and to investigate its clinical performance in participants with suspected myocarditis.Materials and Methods: Eight participants (three women, mean age, 31 years 6 4 [standard deviation]; cohort 1) without a history of cardiac disease and 25 participants (nine women, mean age, 45 years 6 17; cohort 2) with clinically suspected myocarditis underwent accelerated free-breathing 3D whole-heart T2 mapping with 100% respiratory scanning efficiency at 1.5 T. The participants were enrolled from November 2018 to August 2020. Three repeated scans were performed on 2 separate days in cohort 1. Segmental variations in T2 relaxation times of the left ventricular myocardium were assessed, and intrasession and intersession reproducibility were measured. In cohort 2, segmental myocardial T2 values, detection of focal inflammation, and map quality were compared with those obtained from clinical breath-hold two-dimensional (2D) T2 mapping. Statistical differences were assessed using the nonparametric Mann-Whitney and Kruskal-Wallis tests, whereas the paired Wilcoxon signed-rank test was used to assess subjective scores.Results: Whole-heart T2 maps were acquired in a mean time of 6 minutes 53 seconds 6 1 minute 5 seconds at 1.5 mm3 resolution. Breath-hold 2D and free-breathing 3D T2 mapping had similar intrasession (mean T2 change of 3.2% and 2.3% for 2D and 3D, respectively) and intersession (4.8% and 4.9%, respectively) reproducibility. The two T2 mapping sequences showed similar map quality (P = .23, cohort 2). Abnormal myocardial segments were identified with confidence (score 3) in 14 of 25 participants (56%) with 3D T2 mapping and only in 10 of 25 participants (40%) with 2D T2 mapping.Conclusion: High-spatial-resolution three-dimensional (3D) whole-heart T2 mapping shows high intrasession and intersession repro-ducibility and helps provide T2 myocardial characterization in agreement with clinical two-dimensional reference, while enabling 3D assessment of focal disease with higher confidence.