Browsing by Author "Bugedo, Diego A."
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- ItemThe Effective Effect-Site Propofol Concentration for Induction and Intubation with Two Pharmacokinetic Models in Morbidly Obese Patients Using Total Body Weight(LIPPINCOTT WILLIAMS & WILKINS, 2012) Echevarria, Ghislaine C.; Elgueta, Maria F.; Donoso, Maria T.; Bugedo, Diego A.; Cortinez, Luis I.; Munoz, Hernan R.BACKGROUND: Most pharmacokinetic (PK) models used for propofol administration are based on studies in normal-weight patients. Extrapolation of these models for morbidly obese patients is controversial. Using 2 PK models and a target-controlled infusion system, we determined the predicted propofol effect-site concentration (Ce) needed for induction of anesthesia in morbidly obese subjects using total body weight.