Browsing by Author "Brito, Ivan"
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- ItemA Family of Ir(III) Complexes with High Nonlinear Optical Response and Their Potential Use in Light-Emitting Devices(2015) Loeb Luschow, Bárbara; Gonzalez, Ivan A.; Cortes Arriagada, Diego; Dreyse, Paulina A.; Caramori, Stefano; Ledoux Rak, Isabelle; Andrade, Daniel; Brito, Ivan; Soto Arriaza, Marco; Toro Labbé, Alejandro; Sanhueza Vega, Luis
- ItemCrystal structure of 4-chloro-2-methyl-6-(4-(trifluoromethoxy)phenyl)pyrimidine, c12h8clf3n2o(2018) Bertrand, Jean-Luc; Salas, Cristian O.; Brito, Ivan
- ItemPhenoxy- and Phenylamino-Heterocyclic Quinones: Synthesis and Preliminary Anti-Pancreatic Cancer Activity(WILEY-V C H VERLAG GMBH, 2022) Sanchez, Patricio; Salas, Cristian O.; Gallardo-Fuentes, Sebastian; Villegas, Alondra; Veloso, Nicolas; Honores, Jessica; Inman, Martyn; Isaacs, Mauricio; Contreras, Renato; Moody, Christopher J.; Cisterna, Jonathan; Brito, Ivan; Tapia, Ricardo A.The successful application of fragment-based drug discovery strategy for the efficient synthesis of phenoxy- or phenylamino-2-phenyl-benzofuran, -benzoxazole and -benzothiazole quinones is described. Interestingly, in the final step of the synthesis of the target compounds, unusual results were observed on the regiochemistry of the reaction of bromoquinones with phenol and aniline. A theoretical study was carried out for better understanding the factors that control the regiochemistry of these reactions. The substituted heterocyclic quinones were evaluated in vitro to determine their cytotoxicity by the MTT method in three pancreatic cancer cell lines (MIA-PaCa-2, BxPC-3, and AsPC-1). Phenoxy benzothiazole quinone 26a showed potent cytotoxic activity against BxPC-3 cell lines, while phenylamino benzoxazole quinone 20 was the most potent on MIA-PaCa-2 cells. Finally, electrochemical properties of these quinones were determined to correlate with a potential mechanism of action. All these results, indicate that the phenoxy quinone fragment led to compounds with increased activity against pancreatic cancer cells.
- Item(-)-Shikimic Acid as a Chiral Building Block for the Synthesis of New Cytotoxic 6-Aza-Analogues of Angucyclinones(2018) Quinones, Natalia; Hernandez, Santiago; Espinoza Catalan, Luis; Villena, Joan; Brito, Ivan; Cabrera Caballero, Alan Raúl; Salas, Cristian O.; Cuellar Fritis, Mauricio Alcides