Browsing by Author "Brebi, Priscilla"
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- ItemAssessment of Gastritis and Gastric Cancer Risk in the Chilean Population Using the OLGA System(2019) Bellolio, Enrique; Riquelme, Ismael; Riffo Campos, Angela L.; Rueda, Carlos; Ferreccio Readi, Catterina; Villaseca, Miguel; Brebi, Priscilla; Muñoz, Sergio R.; Araya, Juan Carlos
- ItemCellular FLICE-like Inhibitory Protein Long Form (c-FLIPL) Overexpression is Related to Cervical Cancer Progression(2013) Ili, Carmen Gloria; Brebi, Priscilla; Tapia, Oscar; Sandoval, Alejandra; López, Jaime; García Muñoz, Patricia; Leal, Pamela; Sidransky, David; Guerrero Preston, Rafael; Roa Strauch, Juan Carlos Enrique
- ItemConnective Tissue Growth Factor Immunohistochemical Expression Is Associated With Gallbladder Cancer Progression(2013) García Cañete, Patricia; Leal, Pamela; Álvarez, Héctor; Brebi, Priscilla; Ili, Carmen Gloria; Tapia, Oscar; Roa Strauch, Juan Carlos Enrique
- ItemDiagnóstico de la infección por virus papiloma humano en el hombre(2013) Silva, Ramón; León, Daniela; Brebi, Priscilla; Lli, Carmen Gloria; Roa Strauch, Juan Carlos Enrique; Sánchez, Raúl
- ItemEffects of c-FLIPL Knockdown in Cervical Uterine Carcinoma Cell Lines(2015) Ili, Caremen G.; Brebi, Priscilla; García Cañete, Patricia; Leal, Pamela; Lopez, Jaime; Tapia, Oscar; Letelier, Pablo; Weber, Helga; Castillo, Jonathan; Roa Strauch, Juan Carlos Enrique
- ItemEnvironmental and Lifestyle Risk Factors in the Carcinogenesis of Gallbladder Cancer(2022) Pérez Moreno, Pablo; Riquelme, Ismael; García Cañete, Patricia; Brebi, Priscilla; Roa, Juan CarlosGallbladder cancer (GBC) is an aggressive neoplasm that in an early stage is generally asymptomatic and, in most cases, is diagnosed in advanced stages with a very low life expectancy because there is no curative treatment. Therefore, understanding the early carcinogenic mechanisms of this pathology is crucial to proposing preventive strategies for this cancer. The main risk factor is the presence of gallstones, which are associated with some environmental factors such as a sedentary lifestyle and a high-fat diet. Other risk factors such as autoimmune disorders and bacterial, parasitic and fungal infections have also been described. All these factors can generate a long-term inflammatory state characterized by the persistent activation of the immune system, the frequent release of pro-inflammatory cytokines, and the constant production of reactive oxygen species that result in a chronic damage/repair cycle, subsequently inducing the loss of the normal architecture of the gallbladder mucosa that leads to the development of GBC. This review addresses how the different risk factors could promote a chronic inflammatory state essential to the development of gallbladder carcinogenesis, which will make it possible to define some strategies such as anti-inflammatory drugs or public health proposals in the prevention of GBC.
- ItemEvaluation of DNA methylation in promoter regions of SFRP4 and ZAR1 in urine and plasma of women with cervical lesions(2017) Hoffstetter, Rene; Riquelme, Ismael; Andana, Alejandra; Ili, Carmen G.; Buchegger, Kurt; Vargas, Hernan; Brebi, Priscilla; Roa Strauch, Juan Carlos Enrique
- ItemExploring the Genetic Diversity of Epstein–Barr Virus among Patients with Gastric Cancer in Southern Chile(2023) Reyes, María Elena; Zanella, Louise; Riquelme, Ismael; Buchegger, Kurt; Mora-Lagos, Bárbara; Guzmán, Pablo; García Cañete, Patricia; Roa Strauch, Juan Carlos Enrique; Gloria Ili, Carmen; Brebi, PriscillaThe Epstein–Barr virus (EBV) has been associated with gastric cancer (GC), one of the deadliest malignancies in Chile and the world. Little is known about Chilean EBV strains. This study aims to investigate the frequency and genetic diversity of EBV in GC in patients in southern Chile. To evaluate the prevalence of EBV in GC patients from the Chilean population, we studied 54 GC samples using the gold standard detection method of EBV-encoded small RNA (EBER). The EBV-positive samples were subjected to amplification and sequencing of the Epstein–Barr virus nuclear protein 3A (EBNA3A) gene to evaluate the genetic diversity of EBV strains circulating in southern Chile. In total, 22.2% of the GC samples were EBV-positive and significantly associated with diffuse-type histology (p = 0.003). Phylogenetic analyses identified EBV-1 and EBV-2 in the GC samples, showing genetic diversity among Chilean isolates. This work provides important information for an epidemiological follow-up of the different EBV subtypes that may cause GC in southern Chile.
- ItemFrecuencia de la infección por Chlamydia trachomatis en un grupo de mujeres de la Región de la Araucanía, Chile(2013) Silva, Ramón; León, Daniela; Viscarra, Támara; Ili, Carmen; Roa Strauch, Juan Carlos Enrique; Sánchez, Raúl; Guzmán, Pablo; Brebi, Priscilla
- ItemReprimo, a Potential p53-Dependent Tumor Suppressor Gene, Is Frequently Hypermethylated in Estrogen Receptor Alpha-Positive Breast Cancer(2017) Buchegger, Kurt; Riquelme, Ismael; Viscarra, Tamara; Ili, Carmen; Brebi, Priscilla; Hui-Ming Huang, Tim; Roa Strauch, Juan Carlos Enrique
- ItemThe ERK/MAPK pathway is overexpressed and activated in gallbladder cancer(2017) Buchegger, Kurt; Silva, Ramón; López, Jaime; Lli, Carmen; Araya, Juan Carlos; Leal, Pamela; Brebi, Priscilla; Riquelme, Ismael; Roa Strauch, Juan Carlos Enrique